Getting to grips with the plant metabolic network

2007 ◽  
Vol 409 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Lee J. Sweetlove ◽  
David Fell ◽  
Alisdair R. Fernie
Keyword(s):  
Metabolic Network ◽  
Large Scale ◽  
State Of The Art ◽  
Plant Metabolism ◽  
Rapid Progress ◽  
The Past ◽  
Metabolic Network Analysis ◽  
Current State ◽  
Engineer Plant ◽  
Analytical Approaches

Research into plant metabolism has a long history, and analytical approaches of ever-increasing breadth and sophistication have been brought to bear. We now have access to vast repositories of data concerning enzymology and regulatory features of enzymes, as well as large-scale datasets containing profiling information of transcripts, protein and metabolite levels. Nevertheless, despite this wealth of data, we remain some way off from being able to rationally engineer plant metabolism or even to predict metabolic responses. Within the past 18 months, rapid progress has been made, with several highly informative plant network interrogations being discussed in the literature. In the present review we will appraise the current state of the art regarding plant metabolic network analysis and attempt to outline what the necessary steps are in order to further our understanding of network regulation.

scholarly journals Multifaceted origins of sex differences in the brain

2016 ◽  
Vol 371 (1688) ◽  
pp. 20150106 ◽  
Author(s):  
Margaret M. McCarthy
Keyword(s):  
Sex Differences ◽  
State Of The Art ◽  
Human Subjects ◽  
Special Issue ◽  
Molecular Analyses ◽  
The Past ◽  
Current State ◽  
Biological Variable ◽  
Males And Females ◽  
The Brain

Studies of sex differences in the brain range from reductionistic cell and molecular analyses in animal models to functional imaging in awake human subjects, with many other levels in between. Interpretations and conclusions about the importance of particular differences often vary with differing levels of analyses and can lead to discord and dissent. In the past two decades, the range of neurobiological, psychological and psychiatric endpoints found to differ between males and females has expanded beyond reproduction into every aspect of the healthy and diseased brain, and thereby demands our attention. A greater understanding of all aspects of neural functioning will only be achieved by incorporating sex as a biological variable. The goal of this review is to highlight the current state of the art of the discipline of sex differences research with an emphasis on the brain and to contextualize the articles appearing in the accompanying special issue.

scholarly journals Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter

2021 ◽  
Vol 2 ◽  
Author(s):  
Kai-Cheng Yan ◽  
Axel Steinbrueck ◽  
Adam C. Sedgwick ◽  
Tony D. James
Keyword(s):  
State Of The Art ◽  
Fluorescent Chemosensors ◽  
Distant Future ◽  
The Past ◽  
Current Trends ◽  
Current State ◽  
Future Challenges ◽  
Molecule Recognition

Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek to highlight the current state of the art as well as provide our viewpoint on the most significant future challenges remaining in the area. To underscore current trends in the field and to facilitate understanding of the area, we provide the reader with appropriate contemporary examples. We then conclude with our thoughts on the most probable directions that chemosensor development will take in the not-too-distant future.

scholarly journals Using plants to remediate or manage metal-polluted soils: an overview on the current state of phytotechnologies

2021 ◽  
Vol 43 ◽  
pp. e58283
Author(s):  
Clístenes Williams Araújo do Nascimento ◽  
Caroline Miranda Biondi ◽  
Fernando Bruno Vieira da Silva ◽  
Luiz Henrique Vieira Lima
Keyword(s):  
Large Scale ◽  
State Of The Art ◽  
Cost Effective ◽  
Time Frame ◽  
Contaminated Site ◽  
Polluted Soils ◽  
Mining Sites ◽  
Current State ◽  
Remedial Actions ◽  
The Tropics

Soil contamination by metals threatens both the environment and human health and hence requires remedial actions. The conventional approach of removing polluted soils and replacing them with clean soils (excavation) is very costly for low-value sites and not feasible on a large scale. In this scenario, phytoremediation emerged as a promising cost-effective and environmentally-friendly technology to render metals less bioavailable (phytostabilization) or clean up metal-polluted soils (phytoextraction). Phytostabilization has demonstrable successes in mining sites and brownfields. On the other hand, phytoextraction still has few examples of successful applications. Either by using hyperaccumulating plants or high biomass plants induced to accumulate metals through chelator addition to the soil, major phytoextraction bottlenecks remain, mainly the extended time frame to remediation and lack of revenue from the land during the process. Due to these drawbacks, phytomanagement has been proposed to provide economic, environmental, and social benefits until the contaminated site returns to productive usage. Here, we review the evolution, promises, and limitations of these phytotechnologies. Despite the lack of commercial phytoextraction operations, there have been significant advances in understanding phytotechnologies' main constraints. Further investigation on new plant species, especially in the tropics, and soil amendments can potentially provide the basis to transform phytoextraction into an operational metal clean-up technology in the future. However, at the current state of the art, phytotechnology is moving the focus from remediation technologies to pollution attenuation and palliative cares.

scholarly journals Insight and psychosis: the next 30 years

2019 ◽  
Vol 217 (3) ◽  
pp. 521-523 ◽  
Author(s):  
Anthony S. David
Keyword(s):  
Conceptual Development ◽  
State Of The Art ◽  
Involuntary Treatment ◽  
The Past ◽  
Current State ◽  
Decision Making Capacity ◽  
Cognitive Neurosciences ◽  
Clinical Associations ◽  
The Relationship ◽  
Made In

Academic interest in the concept of insight in psychosis has increased markedly over the past 30 years, prompting this selective appraisal of the current state of the art. Considerable progress has been made in terms of measurement and confirming a number of clinical associations. More recently, the relationship between insight and involuntary treatment has been scrutinised more closely alongside the link between decision-making capacity and insight. Advances in the clinical and cognitive neurosciences have influenced conceptual development, particularly the field of ‘metacognition’. New therapies, including those that are psychologically and neurophysiologically based, are being tested as ways to enhance insight.

FOREWORD

Geophysics ◽  
1964 ◽  
Vol 29 (2) ◽  
pp. 151-153 ◽  
Author(s):  
Charles C. Bates
Keyword(s):  
Prime Minister ◽  
State Of The Art ◽  
The United States ◽  
The Political ◽  
Bad Faith ◽  
Political Leaders ◽  
The Past ◽  
Current State ◽  
Nuclear Tests ◽  
Test Ban

A decade ago, it would have been the rare geophysicist indeed who would have predicted that his specialty was destined to become a major topic of discussion between such world political leaders as Presidents Eisenhower and Kennedy, Prime Minister Macmillan of Great Britain, and Chairman Khrushchev of the USSR. Yet this has come to pass during the past six years, for in 1958 there started the continuing round of international negotiations directed towards the creation of an effective underground test-ban treaty. During the conduct of these negotiations, it has been repeatedly necessary to assess the current state-of-the-art in seismology and its sister geophysical sciences, for the only detectable signals known to propagate for several hundreds to thousands of miles from underground nuclear tests are seismic in nature. With the United States policy being only to seek an underground-test-ban agreement incorporating strong safeguards against acts of bad faith, it is important that the political safe-guards be backed up by those of a geophysical nature.

scholarly journals Stereological methods in cell biology: where are we--where are we going?

1981 ◽  
Vol 29 (9) ◽  
pp. 1043-1052 ◽  
Author(s):  
E R Weibel
Keyword(s):  
Cell Biology ◽  
State Of The Art ◽  
Developmental State ◽  
Geometric Probability ◽  
Advanced Level ◽  
Current State ◽  
Morphometric Methods ◽  
Physiological Approach ◽  
Function Correlation ◽  
Analytical Approaches

The current state of the art in morphometric cell biology is reviewed by looking at the developmental state of stereological methods, and at the approaches used to arrive at quantitative structure-function correlation. Stereological methods have reached a fairly advanced level of sophistication since mathematical stereology has been developed as a branch of geometric probability theory. The application of these methods in cell biology lags behind, both quantitatively and qualitatively. Among the strategies used in exploiting stereological methods in cell biology the physiological approach (where a change is induced experimentally and its effect on the cells is followed by biochemical and morphometric methods) ranks highest and is still valid. More analytical approaches, such as combining stereology and biochemistry in cell fraction studies, are fraught with difficulties. In considering future developments of stereological methods, the emphasis will have to be 1) on developing procedures for eliminating biases such as section thickness or resolution effects, and 2) on increasing the efficiency of the methods by better sampling rules and improved instrumentation. The future trends in morphometric cell biology might best be served by exploiting the potentials of histochemistry and stereology by combining them with a view to 1) establishing procedures for cell-specific sampling and 2) developing methods towards "molecular morphometry" on the basis of immunocytochemical labeling.

AN APPLICATION CONCEPT OF THE FIBRE-OPTICAL TECHNOLOGY IN GEODETIC MONITORING OF ENGINEERING OBJECTS

2017 ◽  
Vol 166 (46) ◽  
pp. 60-74
Author(s):  
Krzysztof Karsznia ◽  
Konrad Podawca
Keyword(s):  
Risk Management ◽  
Large Scale ◽  
State Of The Art ◽  
Monitoring Systems ◽  
Management Approach ◽  
Engineering Structures ◽  
Geoinformation Systems ◽  
Current State ◽  
Modern Engineering ◽  
Integrated Risk

Monitoring of structures and other different field objects undoubtedly belongs to the main issues of modern engineering. The use of technologies making it possible to implement structural monitoring makes it possible to build an integrated risk management approach combining instrumental solutions with geoinformation systems. In the studies of engineering structures, there is physical monitoring mainly used for examining the physical state of the object - so-called SHM ("Structural Health Monitoring"). However, very important role is also played by geodetic monitoring systems (GMS). The progress observed in the field of IT and automatics has opened new possibilities of using integrated systems on other, often large-scale objects. Based on the current state-of-the-art, the article presents the concept of integration approaches of physical and geodetic monitoring systems in order to develop useful guidelines for further construction of an expert risk management system.

Real Time Simulation for High Fidelity Multibody Dynamics and Mechatronic Systems

2014 ◽  
Author(s):  
William Prescott
Keyword(s):  
Real Time ◽  
Multibody Dynamics ◽  
Large Scale ◽  
State Of The Art ◽  
High Fidelity ◽  
Implicit Integration ◽  
Mechatronic Systems ◽  
Vehicle Simulation ◽  
Current State ◽  
Time Simulation

This paper will investigate the use of large scale multibody dynamics (MBD) models for real-time vehicle simulation. Current state of the art in the real-time solution of vehicle uses 15 degree of freedom models, but there is a need for higher-fidelity systems. To increase the fidelity of models uses this paper will propose the use of the following techniques: implicit integration, parallel processing and co-simulation in a real-time environment.

scholarly journals The future of multimodal corpora

2011 ◽  
Vol 11 (2) ◽  
pp. 391-415 ◽  
Author(s):  
Dawn Knight
Keyword(s):  
Corpus Linguistics ◽  
State Of The Art ◽  
Future Developments ◽  
The Past ◽  
Current State ◽  
Linguistic Research ◽  
Multimodal Corpora ◽  
The Future ◽  
Multimodal Corpus ◽  
Critical Overview

This paper takes stock of the current state-of-the-art in multimodal corpus linguistics, and proposes some projections of future developments in this field. It provides a critical overview of key multimodal corpora that have been constructed over the past decade and presents a wish-list of future technological and methodological advancements that may help to increase the availability, utility and functionality of such corpora for linguistic research.

scholarly journals Survey of the State of the Art in Natural Language Generation: Core tasks, applications and evaluation

2018 ◽  
Vol 61 ◽  
pp. 65-170 ◽  
Author(s):  
Albert Gatt ◽  
Emiel Krahmer
Keyword(s):  
Natural Language ◽  
State Of The Art ◽  
Natural Language Generation ◽  
Data Driven ◽  
Research Topics ◽  
Language Generation ◽  
The Past ◽  
Current State ◽  
Linguistic Input ◽  
New Applications

This paper surveys the current state of the art in Natural Language Generation (NLG), defined as the task of generating text or speech from non-linguistic input. A survey of NLG is timely in view of the changes that the field has undergone over the past two decades, especially in relation to new (usually data-driven) methods, as well as new applications of NLG technology. This survey therefore aims to (a) give an up-to-date synthesis of research on the core tasks in NLG and the architectures adopted in which such tasks are organised; (b) highlight a number of recent research topics that have arisen partly as a result of growing synergies between NLG and other areas of artificial intelligence; (c) draw attention to the challenges in NLG evaluation, relating them to similar challenges faced in other areas of NLP, with an emphasis on different evaluation methods and the relationships between them.

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