scholarly journals Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues

2004 ◽  
Vol 384 (3) ◽  
pp. 567-575 ◽  
Author(s):  
Takayoshi YAMADA ◽  
Shiori OHTAKE ◽  
Makoto SATO ◽  
Osami HABUCHI
Keyword(s):  
Structural Analysis ◽  
Uronic Acid ◽  
Major Part ◽  
The Other ◽  
Dermatan Sulphate ◽  
Rich Region ◽  
Other Hand ◽  
Iduronic Acid

C4ST-1 (chondroitin 4-sulphotransferase-1) and C6ST-1 (chondroitin 6-sulphotransferase-1) transfer sulphate from PAPS (adenosine 3′-phosphate 5′-phosphosulphate) to positions 4 and 6 respectively of the GalNAc residues of chondroitin. We showed previously that C4ST-1 purified from rat chondrosarcoma and recombinant C4ST-1 both transfer sulphate efficiently to position 4 of the GalNAc residues of DSDS (desulphated dermatan sulphate). We report here the specificity of C4ST-1 and C6ST-1 in terms of uronic acid residue recognition around the GalNAc residue to which sulphate is transferred. When [35S]glycosaminoglycans formed from DSDS after incubation with [35S]PAPS and C4ST-1 were digested with chondroitinase ACII, a major part of the radioactivity was recovered in disaccharide fractions and the remainder distributed to tetrasaccharides and larger fractions, indicating that C4ST-1 mainly transferred sulphate to position 4 of the GalNAc residue located at the GlcA-GalNAc-GlcA sequence. Structural analysis of tetrasaccharide and larger oligosaccharide fractions indicated that C4ST-1 mainly transferred sulphate to the GalNAc residue adjacent to the reducing side of the GlcA residue. On the other hand, when [35S]glycosaminoglycans formed from DSDS after incubation with [35S]PAPS and C6ST-1 were digested with chondroitinase ACII, a major part of the radioactivity was recovered in fractions larger than hexasaccharides, indicating that C6ST-1 transferred sulphate to the GalNAc residues located in the L-iduronic acid-rich region. Structural analysis of the tetrasaccharide and larger oligosaccharide fractions indicated that C6ST-1 showed very little preference for the GalNAc residue neighbouring the GlcA residue. These results indicate that C4ST-1 and C6ST-1 differ from each other in the recognition of uronic acid residues adjacent to the targeted GalNAc residue.

Geography and the Gerrymander

1918 ◽  
Vol 12 (3) ◽  
pp. 403-426 ◽  
Author(s):  
C. O. Sauer
Keyword(s):  
Public Opinion ◽  
Major Part ◽  
The Other ◽  
European Countries ◽  
Large Measure ◽  
Adequate Knowledge ◽  
Other Hand ◽  
Partial Suppression ◽  
Historical Basis ◽  
The Individual

The gerrymander is an American name for a political abuse, which, though by no means exclusively American, has been most widely practiced and generally tolerated in this country. It is a device for the partial suppression of public opinion that simulates agreement with democratic institutions. The subterfuge, therefore, has no place in countries in which oligarchic control is legitimized. Nor is it suited to European conditions, because it is difficult there to shift electoral boundaries. European electoral units in large part have a clearly defined historical basis, which in turn rests upon geographic coherence. This solidarity is commonly so great that it cannot be disregarded. American political divisions on the other hand show in major part very imperfect adjustment to economic and historic conditions, largely, because many of the divisions were created in advance of such conditions. They are, in the main, not gradual growths, but deliberate and arbitrary legislative creations, made without adequate knowledge of the conditions that make for unity or disunity of population within an area. Political divisions tend, therefore, to be less significant than in European countries and to be regarded more lightly. It is in particular the smaller unit, such as the county, that has been manipulated for electoral purposes. In spite of their poorly drawn individual boundaries, groups of counties can be organized into larger electoral units in such a manner as to represent a common body of interests predominating. On the other hand they can be so arranged as to mask these interests. The lack of proper coherence in the individual county may be rectified in large measure in the group, or it may be intensified. Gerrymandering accomplishes the latter result.

“La marquise sortit à cinq heures”

PMLA ◽  
1969 ◽  
Vol 84 (6) ◽  
pp. 1644-1648
Author(s):  
Albert Chesneau
Keyword(s):  
Structural Analysis ◽  
The Other ◽  
Past Tense ◽  
First Person ◽  
The Novel ◽  
Other Hand ◽  
Third Person ◽  
Present Tense ◽  
Nouveau Roman ◽  
The Ideal

Simple structural analysis applied to passages cited from the works of André Breton elucidates the reasons for his condemnation of the statement La marquise sortit à cinq heures (see his Manifeste du surréalisme, 1924) as non-poetic. This study demonstrates the opposition existing between the above-mentioned realist sentence, essentially non-subjective (third-person subject), non-actual (past tense predicate), contextual (context can be supposed), and prosaic (lack of imagery), and on the other hand a theoretic surrealist sentence, essentially subjective (first-person subject), actual (present tense predicate), and non-contextual, producing a shock-image. In reality, Breton's surrealistic phrase does not always contain all of these qualities at once. However, in contrast to the condemned phrase which contains none at all, it does always manifest at least one of these characteristics, the most important having reference to the evocative power of the shock-image. A final comparison with a sentence quoted from Robbe-Grillet, the theoretician of the “nouveau roman”, proves that even though it may appear objective, the surrealist phrase is really not so. In conclusion, the four characteristics of the ideal surrealist sentence—subjectivity, actuality, non-contextuality, and ability to produce shock-images—create a poetics of discontinuity opposed to the classical art of narration as found traditionally in the novel. (In French)

scholarly journals Structure of heparan sulphate oligosaccharides and their degradation by exo-enzymes

1979 ◽  
Vol 183 (3) ◽  
pp. 711-720 ◽  
Author(s):  
A Linker
Keyword(s):  
Structural Analysis ◽  
Nitrous Acid ◽  
Uronic Acid ◽  
Glucuronic Acid ◽  
Heparan Sulphate ◽  
Major Fraction ◽  
Sulphate Content ◽  
Acid Degradation ◽  
Iduronic Acid ◽  
Heparan Sulphate Chain

Oligosaccharides obtained from heparan sulphate by nitrous acid degradation were shown to be degraded sequentially by beta-D-glucuronidase or alpha-L-iduronidase followed by alpha D-N-acetylglucosaminidase. Structural analysis of the tetrasaccharide fraction showed the following. (1) N-Acetylglucosamine is preceded by a non-sulphated uronic acid residue that can be either D-glucuronic of L-iduronic acid, but followed by a glucuronic acid residue. (2) The N-acetylglucosamine in the major fraction is sulphated. (3) Very few if any of the uronic acid residues are sulphated (4). The results indicate that the area of the heparan sulphate chain where disaccharides containing N-acetylglucosamine and N-sulphated glucosamine residues alternate is higher in sulphate content than expected and that the sulphate groups are mainly located on the hexosamine units.

scholarly journals LANDSCAPE ADAPTATION AND RECONSTRUCTION DURING KAUNAS FORTRESS CONSTRUCTION

2006 ◽  
Vol 30 (4) ◽  
pp. 204-218
Author(s):  
Nijolė Steponaitytė
Keyword(s):  
European Union ◽  
Major Part ◽  
The Other ◽  
Construction Process ◽  
The European Union ◽  
Other Hand ◽  
Visual Influence ◽  
The City

In spring of 2005 Kaunas city became a partner in the project “Baltic Fort Route“ of the program INTERREG IIIB BSR financed by the European Union. The aim of the project is preservation and effective adaptation of fortress territories for tourism. On the other hand, it should be observed that free land areas in Kaunas and around it are being intensively assimilated what may do damage to the defence objects of Kaunas Fortress and thus deteriorate their visual significance. The limits of landscape modifications should be clearly determined. During the construction process of the Fortress the peculiarities of the geomorphological system and hydrographic net of Kaunas environs were well explored and considered. The whole landscape of Kaunas environs was reconstructed according to the needs of the Fortress. The defence objects of the Fortress still have a great effect on the landscape of the city and its surrounding territories. Major part of the territories of the Fortress objects were turned into the areas of green plantation. According to the visual influence of the forts and fortifications on the environment, the mentioned objects may be divided into groups. The author presents proposals on the management of the defence objects and areas of green plantation of the Fortress that could provide for maximal possibilities in respecting their authentic view.

Der Baum und das Raster

2019 ◽  
Vol 2019 (1) ◽  
pp. 9-19
Author(s):  
Philippe Descola
Keyword(s):  
United States ◽  
World War Ii ◽  
Structural Analysis ◽  
The United States ◽  
The Other ◽  
Original Form ◽  
World War ◽  
Other Hand ◽  
Biological Form ◽  
The One

Claude Levi-Strauss mentioned several times in his work that the notion of transformation is the keystone of the structural analysis he pratices. By his own admission, this notion stems from his reading of D’Arcy Thomson’s book On Growth and Form during World War II in the United States. But Levi-Strauss makes use of two very different meanings of transformation, relating to two distinct morpho-genetic traditions. On the one hand, he is inspired by Goethe’s Morphology. All forms can be seen as transformation of a Urform, an original form, from which they grow out like a tree. But on the other hand, D’Arcy Thomson’s emphasis lies on the geometric simplicity of a transformation grid that allows the transition from one biological form to the other without considering any original from which other forms would be derivable. Levi-Strauss’ epistemological choice to study myths and masks can be better understood when his concept of transformation is clearly defined in relation to Goethe and D’Arcy Thomson. Thus, the originality of his own interpretation will become clear

scholarly journals STRUCTURAL ANALYSIS OF LEGAL CULTURE

2016 ◽  
pp. 0-0
Author(s):  
Алексей Автономов ◽  
Alyeksyey Avtonomov
Keyword(s):  
Structural Analysis ◽  
Research Methods ◽  
Social Environment ◽  
Legal Culture ◽  
The State ◽  
The Other ◽  
Other Hand ◽  
The One ◽  
And Behavior ◽  
Theoretical Issues

The article is devoted to theoretical issues of using one of the research methods — structural analysis — for legal culture studying. Legal culture is a kind of a layer in social environment that represents one of the regulatory types. Law in its functioning is closely connected with the state, but rules of that law are rooted in societal life, resting upon the ideas of fairness which are dominant in the society under specific historical conditions. Legal culture manifests itself in the samples (models) of behavior and values. Legal culture combines the rational and the irrational. Legal culture is formed and developed under concrete historical conditions and, on the one hand, relies on law, being one of the legal phenomena (hence, the existence of law is the indispensable prerequisite for the existence of legal culture), and on the other hand, it is a factor of ensuring law existence and enforcement, because any rules that do not meet the dominant society’s values and predominant behavior samples (models), would be invalid: either they will be ignored and not applied or attempts will be made to adapt them to the values and behavior samples (models) by means of interpretation, enforcement practices, etc. (but as a result of that, the content of the rules will be different), or such rules will be changed or cancelled.

Implements and Vessels used in Vedic Sacrifice

1934 ◽  
Vol 66 (2) ◽  
pp. 283-305
Author(s):  
Raghu Vira
Keyword(s):  
Major Part ◽  
Religious Life ◽  
The Other ◽  
Other Hand ◽  
Vedic Literature ◽  
Long Life

Every student of Vedic literature is confronted by vast details of an uncommonly complicated ritual. This ritual engrossed the major part of the religious life of a householder. Every small act promised him riches in cattle and progeny, long life and bliss in the next world. On the other hand, the slightest negligence had to be assiduously atoned for, otherwise it would lead him into misery. Thus it is that even the ropes, the brooms, and their numbers have been carefully recorded, the materials of which they were made, their size, and their functions prescribed with the same thoroughness as the crushing of the soma-juice or the coronation of the king.

Structure of Heparin and Related Glycosaminoglycans

1979 ◽  
Author(s):  
B. Casu
Keyword(s):  
Functional Groups ◽  
Plasma Proteins ◽  
Glucuronic Acid ◽  
The Other ◽  
Hybrid Structures ◽  
Dermatan Sulphate ◽  
Iduronic Acid

The structure of heparin is largely accounted for by disaccharide sequences of α1,4-linked 2-0-sulphated L-iduroic acid and N,6-0-disulphated D-glucosamine. However, the insertion of other residues (especially D-glucuronic acid, nor-sulphated L-iduronic acid and N-acetylated D-glucosamine) leads to hybrid structures. Also the other iduromc acid-containing glycosaminoglycans are structurally heterogeneous. Heparan sulphates contain variable amounts of heparin-like blocks, ana dermatan sulphate contains also chondroitin -like segments.Available evidence on the structure and conformation of the above glycosaminoglycans will be discussed in terms of the availability ot individual functional groups for interaction with plasma proteins.

scholarly journals Paweł Szymański’s Self-Analyses Reread

2015 ◽  
Vol 12 (1) ◽  
pp. 90-98 ◽  
Author(s):  
Katarzyna Naliwajek-Mazurek
Keyword(s):  
Major Part ◽  
The Other ◽  
Musical Language ◽  
Luciano Berio ◽  
Other Hand

Abstract The article is an attempt to present important categories of composer Paweł Szymański’s musical language, based on his self-analytical statements, which were in major part answers to musicologists’ questions. Luciano Berio pointed out why the situation of a composer who would like to address questions about his or her music is difficult - a lack of necessary detachment would be one of the reasons. A musicologist, on the other hand, is tempted to construct their own supposedly objective analytical view of a composer’s musical language. The dialogistic approach proposed by anthropological musicology may be a solution to these dilemmas. Other main topics mentioned in the article are related to the role of meta-concepts in Szymański’s musical language.

scholarly journals DEMOGRAPHIC CONSEQUENCES OF THE 1946–1947 FAMINE (ON THE MATERIALS OF THE URALS)

2021 ◽  
Vol 70 (1) ◽  
pp. 47-59
Author(s):  
Nikolay A. Mikhalev ◽  
Keyword(s):  
Structural Analysis ◽  
Causes Of Death ◽  
Excess Mortality ◽  
The Other ◽  
The Urals ◽  
Other Hand ◽  
Short Period ◽  
Basic Approaches ◽  
Post War ◽  
The One

The article deals with examination of the main parameters of the post-war 1946–1947 famine’s impact on the demographic sphere of the Urals. It considers the basic approaches proposed by Russian and foreign researchers to determine the level of excess mortality under conditions of the famine. Some of them were used to assess its scale in the Urals. The changes that took place in the processes of reproduction of the region’s population are revealed. Particular attention is paid to the structural analysis of mortality processes. The specifics of registration of deaths from alimentary dystrophy in the consolidated demographic forms are shown, their share in the corresponding group of causes of death is determined. The transformation of fertility processes is considered, the size of its decrease under the influence of the famine is established. The 1946–1947 famine led to an increase in mortality, it virtually interrupted a short period of post-war compensation of the population, which turned out to be insufficient and incomplete. Estimates of direct losses from the famine vary, but they all inevitably have the character of rough, tentative assumptions. On the one hand, this is due to the limitations imposed by the informative potential of the sources available to researchers today. On the other hand, the reason lies in an extraordinary nature of the very period, marked by a multitude of turbulent events that destabilized the situation, when it becomes almost impossible to find the demographic norm on which calculations should be made.

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