scholarly journals Is regulation of proteolysis associated with redox-state changes in rat skeletal muscle?

1980 ◽  
Vol 192 (3) ◽  
pp. 963-966 ◽  
Author(s):  
M E Tischler
Keyword(s):  
Skeletal Muscle ◽  
Oxidation State ◽  
Redox State ◽  
Proteinase Activity ◽  
Rat Skeletal Muscle ◽  
Direct Inhibition ◽  
State Changes ◽  
Isolated Rat

In isolated rat diaphragms, only those substrates that increased the tissue NADH/NAD+ ratio lowered the rate of proteolysis. However, direct inhibition of proteinase activity by leupeptin promoted oxidation of the NAD couple of the muscles. These results suggest that changes in muscle reduction-oxidation state may be important in the regulation of proteolysis.

scholarly journals Control of rat skeletal-muscle phosphorylase phosphatase activity by adrenaline

1978 ◽  
Vol 176 (1) ◽  
pp. 347-350 ◽  
Author(s):  
S H Tao ◽  
F L Huang ◽  
A Lynch ◽  
W H Glinsmann
Keyword(s):  
Skeletal Muscle ◽  
Cyclic Amp ◽  
Phosphatase Activity ◽  
Glycogen Synthase ◽  
Rat Skeletal Muscle ◽  
Inhibitor Activity ◽  
Phosphatase Inhibitor ◽  
Heat Stable ◽  
Muscle Phosphorylase ◽  
Isolated Rat

Administration of adrenaline to an isolated rat hindlimb preparation rapidly decreased muscle phosphorylase phosphatase (EC 3.1.3.17) activity and increased heat-stable and trypsin-labile phosphatase inhibitor activity. This was associated with increased tissue cyclic AMP concentrations, phosphorylase (EC 2.4.1.1) activation and glycogen synthase (EC 2.4.1.11) inactivation.

scholarly journals Effects of concentric and eccentric contractions on phosphorylation of MAPK erk1/2 and MAPK p38 in isolated rat skeletal muscle

2001 ◽  
Vol 535 (1) ◽  
pp. 155-164 ◽  
Author(s):  
Charlott Wretman ◽  
Arimantas Lionikas ◽  
Ulrika Widegren ◽  
Jan Lännergren ◽  
Håkan Westerblad ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Eccentric Contractions ◽  
Rat Skeletal Muscle ◽  
Isolated Rat

scholarly journals Purine biosynthesis de novo in rat skeletal muscle

1983 ◽  
Vol 216 (3) ◽  
pp. 605-610 ◽  
Author(s):  
T G Sheehan ◽  
E R Tully
Keyword(s):  
Skeletal Muscle ◽  
Extensor Digitorum Longus ◽  
De Novo ◽  
Adenine Nucleotides ◽  
Extensor Digitorum ◽  
Purine Biosynthesis ◽  
Rat Skeletal Muscle ◽  
Purine Synthesis ◽  
Longus Muscle ◽  
Isolated Rat

Purine biosynthesis by the ‘de novo’ pathway was demonstrated in isolated rat extensor digitorum longus muscle with [1-14C]glycine, [3-14C]serine and sodium [14C]formate as nucleotide precursors. Evidence is presented which suggests that the source of glycine and serine for purine biosynthesis is extracellular rather than intracellular. The relative incorporation rates of the three precursors were formate greater than glycine greater than serine. Over 85% of the label from formate and glycine was recovered in the adenine nucleotides, principally ATP. Azaserine markedly inhibited purine biosynthesis from both formate and glycine. Cycloserine inhibited synthesis from serine, but not from formate. Adenine, hypoxanthine and adenosine markedly inhibited purine synthesis from sodium [14C]formate.

IL-10 PREVENTS VASODILATATION OF ISOLATED RAT SKELETAL MUSCLE ARTERIOLES EXPOSED TO ENDOTOXIN.

Shock ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. 36
Author(s):  
B. Tan ◽  
R. Prewitt ◽  
L. D. Britt
Keyword(s):  
Skeletal Muscle ◽  
Rat Skeletal Muscle ◽  
Isolated Rat
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