scholarly journals Complex lipids of a lipolytic and general-fatty-acid-requiring Butyrivibrio sp. isolated from the ovine rumen

1980 ◽  
Vol 191 (2) ◽  
pp. 555-560 ◽  
Author(s):  
G P Hazlewood ◽  
N G Clarke ◽  
R M C Dawson
Keyword(s):  
Fatty Acid ◽  
Minor Component ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Naturally Occurring ◽  
Phosphorus Containing ◽  
Complex Lipids ◽  
Fatty Acid Supplement ◽  
A Minor ◽  
Long Chain

The complex lipids of the naturally-occurring general-fatty-acid-auxotroph Butyrivibrio S2 [Hazlewood & Dawson (1979) J. Gen. Microbiol. 112, 15-27] grown with palmitic acid as sole fatty-acid supplement have been investigated and some have been isolated in a state of purity and analysed. The majority are phospholipids (84%) and many contain galactose. They typically possess few esterified long-chain fatty-acid residues (C16:0), but are rich in esterified butyric acid and C16-alkenyl groups. Most of the phosphorus-containing lipids, including the two major lipids of the organism, contain esterified diabolic acid, a long-chain vicinal dimethyl-substituted dicarboxylic acid [Klein, Hazlewood, Kemp & Dawson (1979) Biochem. J. 183, 691-700] in definite stoichiometric relationship to phosphorus. No phosphatidylglycerol was present, but its monobutyroyl ester was detected as a minor component. Galactofuranosyldiacylglycerol (plasmalogen) and its monobutyroyl ester, cetyl alcohol and diacylglycerol were also identified.

Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts

1995 ◽  
Vol 268 (6) ◽  
pp. H2505-H2512 ◽  
Author(s):  
M. C. Madden ◽  
P. E. Wolkowicz ◽  
G. M. Pohost ◽  
J. B. McMillin ◽  
M. M. Pike
Keyword(s):  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Minor Role ◽  
Long Chain Fatty Acid ◽  
Exogenous Substrate ◽  
Rat Hearts ◽  
Cpt I ◽  
A Minor ◽  
Perfused Hearts ◽  
Long Chain

Carnitine palmitoyltransferase-I (CPT-I) inhibitors improve postischemic myocardial function either by decreasing muscle long-chain acylcarnitines (LCAC) during ischemia or by increasing oxidation of alternate substrates such as glucose during reperfusion. These possibilities were evaluated using oxfenicine, a CPT-I inhibitor, and alternate substrates that bypass carnitine-dependent metabolism. Isolated rat hearts subjected to 20 min of ischemia followed by 40 min of reperfusion with 1.8 mM palmitate as exogenous substrate recovered little function during reperfusion. Hearts made ischemic and reperfused with palmitate and 2.4 mM hexanoate as exogenous substrates had significantly improved reperfusion function compared to palmitate-perfused hearts. Addition of 2 mM oxfenicine to palmitate-hexanoate-perfused hearts gave an additional small improvement in reperfusion function. At the end of ischemia, the LCAC content of hearts perfused with palmitate or hexanoate and palmitate was identical. Palmitate-, hexanoate, and oxfenicine-perfused hearts had significantly decreased LCAC content at the end of ischemia compared with hexanoate-palmitate-perfused hearts. Therefore, depressed reperfusion function in long-chain fatty acid-perfused hearts can be ameliorated by alternate substrates, including medium-chain fatty acids. LCAC accumulation during ischemia apparently plays only a minor role in the postischemic dysfunction of long-chain fatty acid-perfused hearts.

scholarly journals Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes

2000 ◽  
Vol 41 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Karin A. J.M. van der Lee ◽  
Michaël M. Vork ◽  
Johan E. De Vries ◽  
Peter H.M. Willemsen ◽  
Jan F.C. Glatz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Cardiac Myocytes ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Induced Changes ◽  
Long Chain

scholarly journals 588 Distinct Roles of the Long-Chain Fatty Acid Receptor GPR120 in Different Cell Types of the Intestinal Epithelium

2014 ◽  
Vol 146 (5) ◽  
pp. S-110-S-111
Author(s):  
Arivarasu Natarajan Anbazhagan ◽  
Shubha Priyamvada ◽  
Tarunmeet Gujral ◽  
Waddah A. Alrefai ◽  
Pradeep K. Dudeja ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Intestinal Epithelium ◽  
Cell Types ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Acid Receptor ◽  
Different Cell Types ◽  
Long Chain ◽  
Fatty Acid Receptor
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