scholarly journals The distribution of glutathione in the rat liver lobule

1979 ◽  
Vol 182 (1) ◽  
pp. 103-108 ◽  
Author(s):  
M T Smith ◽  
N Loveridge ◽  
E D Wills ◽  
J Chayen
Keyword(s):  
Rat Liver ◽  
Reduced Glutathione ◽  
Central Vein ◽  
Electrophilic Attack ◽  
Liver Lobule ◽  
Microsomal Cytochrome ◽  
Cytochemical Method ◽  
Toxic Metabolites ◽  
Cytochrome P 450

A quantitative cytochemical method was developed for measuring the GSH (reduced glutathione) content of hepatocytes in different regions of the rat liver lobule. Use of this method enabled us to show that GSH is not evenly distributed within the rat liver lobule. The hepatocytes located within 100 micrometer of the central vein contain much less GSH than do those in other regions of the rat liver lobule. We suggest that this partially explains the peculiar susceptibility of these cells to electrophilic attack by toxic metabolites formed via the microsomal cytochrome P-450 system.

Molecular Multiplicity and Gene Structure of Microsomal Cytochrome P-450 in Rat Liver

1985 ◽  
pp. 157-169
Author(s):  
Yoshiaki Fujii-Kuriyama ◽  
Kazuhiro Sogawa ◽  
Yuzuru Mizukami ◽  
Yorimasa Suwa ◽  
Masami Muramatsu ◽  
...  
Keyword(s):  
Rat Liver ◽  
Gene Structure ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone)

1986 ◽  
Vol 35 (8) ◽  
pp. 1391-1394 ◽  
Author(s):  
Peng Renxiu ◽  
Zhu Xiu-Yuan ◽  
Chung S. Yang
Keyword(s):  
Rat Liver ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Aflatoxin B1 hydroxylation by the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P-450

1988 ◽  
Vol 9 (11) ◽  
pp. 2103-2108 ◽  
Author(s):  
Michael R. Halvorson ◽  
Steven H. Safe ◽  
Andrew Parkinson ◽  
Timothy D. Phillips
Keyword(s):  
Rat Liver ◽  
Aflatoxin B1 ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254

1983 ◽  
Vol 225 (1) ◽  
pp. 203-215 ◽  
Author(s):  
Andrew Parkinson ◽  
Paul E. Thomas ◽  
Dene E. Ryan ◽  
Linda M. Reik ◽  
Stephen H. Safe ◽  
...  
Keyword(s):  
Rat Liver ◽  
Epoxide Hydrolase ◽  
Time Course ◽  
Aroclor 1254 ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Studies on the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase

1987 ◽  
Vol 36 (22) ◽  
pp. 3859-3866 ◽  
Author(s):  
Michael P. Arlotto ◽  
Andrew J. Sonderfan ◽  
Curtis D. Klaassen ◽  
Andrew Parkinson
Keyword(s):  
Rat Liver ◽  
Microsomal Cytochrome ◽  
Udp Glucuronosyltransferase ◽  
Cytochrome P 450

Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4′-substituted-2,3,4,5-tetrachlorobiphenyls

Toxicology ◽  
1988 ◽  
Vol 53 (2-3) ◽  
pp. 289-300 ◽  
Author(s):  
A. Parkinson ◽  
P.E. Thomas ◽  
D.E. Ryan ◽  
W. Levin ◽  
T. Fujita ◽  
...  
Keyword(s):  
Rat Liver ◽  
Epoxide Hydrolase ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450
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