scholarly journals Permeability of the liver cell membrane to quinolinate

1977 ◽  
Vol 164 (1) ◽  
pp. 283-286 ◽  
Author(s):  
K R F Elliott ◽  
C I Pogson ◽  
S A Smith
Keyword(s):  
Steady State ◽  
Cell Membrane ◽  
Guinea Pig ◽  
Liver Cell ◽  
Liver Cells ◽  
Pig Liver ◽  
Liver Cell Membrane ◽  
Guinea Pig Liver

Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.

scholarly journals THE PREPARATION OF SECTIONS OF GUINEA PIG LIVER FOR ELECTRON MICROSCOPY

1946 ◽  
Vol 83 (6) ◽  
pp. 499-503 ◽  
Author(s):  
Albert Claude ◽  
Ernest F. Fullam
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Guinea Pig ◽  
Liver Cells ◽  
The Other ◽  
Ground Substance ◽  
Pig Liver ◽  
Guinea Pig Liver

1. A method is described whereby sections of guinea pig liver cells can be prepared for electron microscopy after fixation. 2. The high resolving powerof the electron microscope reveals the presence of two components, one particulate, the other apparently of fibrous texture, in the ground substance of the cells.

scholarly journals TRANSFORMATION OF A HISTOCOMPATIBILITY IMMUNOGEN INTO A TOLEROGEN

1973 ◽  
Vol 138 (3) ◽  
pp. 723-733 ◽  
Author(s):  
Stephen H. Nimelstein ◽  
Allan R. Hotti ◽  
Halsted R. Holman
Keyword(s):  
Structural Change ◽  
Cell Membrane ◽  
Spleen Cell ◽  
Liver Cell ◽  
Cellular Response ◽  
Cell Membranes ◽  
Humoral Response ◽  
Cellular Responses ◽  
Liver Cells ◽  
Liver Cell Membrane

H-2 antigens on spleen cell membranes absorb antibody to H-2 antigens and induce both humoral and cellular responses. Liver cell membrane H-2 antigens by contrast also absorb antibody but do not influence cellular response and are tolerogenic for the humoral response. This paper demonstrates that syngeneic liver cells contain a substance which can transform the properties of allogeneic spleen cell membranes into those of allogeneic liver cell membranes, i.e., transform a humoral immunogen into a humoral tolerogen. The process appears to be accompanied by cleavage of an antigen component from the spleen membrane and hence to result in a structural change in the H-2 antigen.

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