scholarly journals Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes

1977 ◽  
Vol 161 (3) ◽  
pp. 639-642 ◽  
Author(s):  
B R Martin ◽  
M D Houslay ◽  
E L Kennedy
Keyword(s):  
Adenylate Cyclase ◽  
Cholera Toxin ◽  
Rat Liver ◽  
Nicotinamide Adenine Dinucleotide ◽  
Plasma Membranes ◽  
Nicotinamide Adenine ◽  
Isolated Rat Liver ◽  
Liver Plasma Membranes ◽  
Rat Liver Plasma Membranes ◽  
Isolated Rat

Activation of adenylate cyclase in isolated rat liver plasma membranes by cholera toxin was demonstrated. The activation requires the presence of NAD+ and ATP and is irreversible.

scholarly journals HEXAGONAL ARRAY OF SUBUNITS IN TIGHT JUNCTIONS SEPARATED FROM ISOLATED RAT LIVER PLASMA MEMBRANES

1968 ◽  
Vol 38 (1) ◽  
pp. 15-24 ◽  
Author(s):  
E. L. Benedetti ◽  
P. Emmelot
Keyword(s):  
Tight Junctions ◽  
Rat Liver ◽  
Plasma Membranes ◽  
Hexagonal Array ◽  
Structural Differentiation ◽  
Isolated Rat Liver ◽  
Zonulae Occludentes ◽  
Liver Plasma Membranes ◽  
Rat Liver Plasma Membranes ◽  
Isolated Rat

Solubilization of isolated rat liver plasma membranes in 1% deoxycholate and centrifugation yielded a fraction (pellet) that consisted mainly of tight junctions (zonulae occludentes). An hexagonal array of subunits similar to that previously found in a number of the unfractionated plasma membranes was demonstrated in all the membrane sheets of these preparations by negative staining. It is concluded that the hexagonal subunit pattern is present in the tight junctions, and that this structural differentiation may be related to the intercellular diffusion afforded by the junctional membrane.

Cholic Acid Binding to Isolated Rat Liver Plasma Membranes

1977 ◽  
Vol 358 (1) ◽  
pp. 543-554 ◽  
Author(s):  
M. Sawkat ANWER ◽  
Reinhard KROKER ◽  
Dietmar HEGNER ◽  
Alfred PETTER
Keyword(s):  
Cholic Acid ◽  
Rat Liver ◽  
Plasma Membranes ◽  
Isolated Rat Liver ◽  
Liver Plasma Membranes ◽  
Rat Liver Plasma Membranes ◽  
Isolated Rat
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