scholarly journals Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat

1976 ◽  
Vol 154 (1) ◽  
pp. 49-56 ◽  
Author(s):  
P C Foster ◽  
E Bailey
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Outer Mitochondrial Membrane ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Carnitine Acyltransferase ◽  
Mitochondrial Fatty Acid ◽  
Foetal Life ◽  
Hydroxyacyl Coa Dehydrogenase ◽  
Hepatic Fatty Acid Oxidation

1. Changes in the activities of several enzymes involved in mitochondrial fatty acid oxidation were measured in livers of developing rats between late foetal life and maturity. The enzymes studied are medium- and long-chain ATP-dependent acyl-CoA synthetases of the outer mitochondrial membrane and matrix, GTP-dependent acyl-CoA synthetase, carnitine acyltransferase, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, general 3-oxoacyl-CoA thiolase and acetoacetyl-CoA thiolase.

scholarly journals Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation

1983 ◽  
Vol 216 (2) ◽  
pp. 499-502 ◽  
Author(s):  
K McCormick ◽  
V J Notar-Francesco ◽  
K Sriwatanakul
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Acetyl Coa ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Acyltransferase Activity ◽  
Carnitine Acyltransferase ◽  
Mitochondrial Transfer ◽  
Mitochondrial Fatty Acid ◽  
Chain Acyl

At micromolar concentrations, acetyl-CoA inhibited hepatic carnitine acyltransferase activity and mitochondrial fatty acid oxidation. The inhibitory effects were not nearly as potent on a molar basis as those of malonyl-CoA; nevertheless, the cytosolic concentrations of acetyl-CoA, as yet unknown, may be sufficient (greater than 30 microM) to curtail appreciably the mitochondrial transfer of long-chain acyl-CoA units and fatty acid oxidation. Hence acetyl-CoA may also partially regulate hepatic ketogenesis.

scholarly journals Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

2015 ◽  
Vol 308 (2) ◽  
pp. R131-R137 ◽  
Author(s):  
Abdelhak Mansouri ◽  
Gustavo Pacheco-López ◽  
Deepti Ramachandran ◽  
Myrtha Arnold ◽  
Claudia Leitner ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Food Intake ◽  
Fatty Acid Oxidation ◽  
Food Deprivation ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Protein Levels ◽  
Malonyl Coa ◽  
Mitochondrial Fatty Acid ◽  
Hepatic Fatty Acid Oxidation

Hepatic fatty acid oxidation (FAO) has long been implicated in the control of eating. Nevertheless, direct evidence for a causal relationship between changes in hepatic FAO and changes in food intake is still missing. Here we tested whether increasing hepatic FAO via adenovirus-mediated expression of a mutated form of the key regulatory enzyme of mitochondrial FAO carnitine palmitoyltransferase 1A (CPT1mt), which is active but insensitive to inhibition by malonyl-CoA, affects eating and metabolism in mice. CPT1mt expression increased hepatocellular CPT1 protein levels. This resulted in an increase in circulating ketone body levels in fasted CPT1mt-expressing mice, suggesting an increase in hepatic FAO. These mice did not show any significant changes in cumulative food intake, energy expenditure, or respiratory quotient after 4-h food deprivation. After 24-h food deprivation, however, the CPT1mt-expressing mice displayed increased food intake. Thus expression of CPT1mt in the liver increases hepatic FAO capacity, but does not inhibit eating. Rather, it may even stimulate eating after prolonged food deprivation. These data do not support the hypothesis that an increase in hepatic FAO decreases food intake.

scholarly journals l-carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA

1989 ◽  
Vol 262 (3) ◽  
pp. 801-806 ◽  
Author(s):  
J P Derrick ◽  
R R Ramsay
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Marker Enzyme ◽  
Mitochondrial Enzyme ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Peroxisomal Enzyme ◽  
Carnitine Acyltransferase ◽  
Malonyl Coa ◽  
Mitochondrial Fatty Acid

Inhibition of the overt mitochondrial carnitine palmitoyltransferase by malonyl-CoA is important in the regulation of fatty acid oxidation. In the past, the contribution of peroxisomal carnitine acyltransferase activity to the generation of medium- and long-chain acylcarnitines in the cytoplasm has been ignored. On the basis of marker enzyme levels, we now estimate that peroxisomal palmitoyltransferase activity constitutes about 20% of the peroxisomal plus overt-mitochondrial pool in fed rat liver. When assayed in situ, both the palmitoyltransferase and decanoyltransferase activities of gradient-purified peroxisomes are sensitive to malonyl-CoA, with up to 90% inhibition reached at less than 10 microM-malonyl-CoA. Very similar results were obtained with intact gradient-purified mitochondria from the same livers. In addition, the acyl-CoA substrate chain-length specificity was identical in both the peroxisomes and the mitochondria, with a decanoyltransferase/palmitoyltransferase ratio of 2. Thus the overt carnitine acyltransferase activities in peroxisomes and mitochondria have the same properties. Further, the malonyl-CoA sensitivity of the peroxisomal activity is lost on solubilization, as has been observed for the overt mitochondrial enzyme. It is suggested that malonyl-CoA inhibition of the peroxisomal enzyme as well as of the mitochondrial enzyme is important for the regulation of mitochondrial fatty acid oxidation.

Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

2019 ◽  
Author(s):  
Helena Urquijo ◽  
Emma N Panting ◽  
Roderick N Carter ◽  
Emma J Agnew ◽  
Caitlin S Wyrwoll ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Fetal Heart ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid

scholarly journals Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation.

1991 ◽  
Vol 266 (34) ◽  
pp. 22932-22938
Author(s):  
R.S. Kler ◽  
S. Jackson ◽  
K. Bartlett ◽  
L.A. Bindoff ◽  
S. Eaton ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid

PRENATAL DIAGNOSIS OF MITOCHONDRIAL FATTY ACID OXIDATION DEFECTS

1996 ◽  
Vol 16 (2) ◽  
pp. 117-124 ◽  
Author(s):  
MOHAMED A. NADA ◽  
CHRISTINE VIANEY-SABAN ◽  
CHARLES R. ROE ◽  
JIA-HUAN DING ◽  
MONIQUE MATHIEU ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Prenatal Diagnosis ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid
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