scholarly journals Ox liver glutamate dehydrogenase. The role of lysine-126 reappraised in the light of studies of inhibition and inactivation by pyridoxal 5'-phosphate

1975 ◽  
Vol 149 (3) ◽  
pp. 619-626 ◽  
Author(s):  
S S Chen ◽  
P C Engel
Keyword(s):  
Glutamate Dehydrogenase ◽  
Time Course ◽  
Competitive Inhibition ◽  
Bovine Liver ◽  
Chemical Modifier ◽  
Order Analysis ◽  
The One ◽  
Step Mechanism

The time-course of inactivation of bovine liver glutamate dehydrogenase by pyridoxal 5'-phosphate was studied in the presence of varied amounts of 2-oxoglutarate or NADH. Pseudo-first-order analysis reveals that the protection by both these compounds is competitive with respect to the chemical modifier. The competition is only partial, however: saturation with either NADH or 2-oxoglutarate decreases the rate constant for inactivation to a finite minimum and not to zero. Similarly, the plot of activity at equilibrium as a function of the concentration of the protecting substrate or coenzyme reveals that neither NADH nor 2-oxoglutarate protects completely against inactivation. In initial-rate experiments, pyridoxal 5'-phosphate, used as an instantaneous inhibitor rather than a long-term inactivator, displayed non-competitive inhibition with respect to both 2-oxoglutarate and NADH. These results clearly indicate that, although there is mutual hindrance between the binding to the enzyme of pyridoxal 5'-phosphate, on the one hand, and 2-oxoglutarate or NADH on the other, binding is not mutually exclusive. These findings are discussed in terms of the two-step mechanism for inactivation by pyridoxal 5'-phosphate. It is concluded that lysine-126 cannot be solely responsible for binding either the substrate or the coenzyme, but could be essential for the catalytic step.

Facing Strangers in Need

2019 ◽  
Vol 11 (1) ◽  
pp. 15-30
Author(s):  
Nenad Miscevic ◽  
Keyword(s):  
A Priori ◽  
The Other ◽  
Refugee Crisis ◽  
Psychological Approach ◽  
Social Psychological ◽  
The Social ◽  
Decent Life ◽  
The One

What is the role of toleration in the present-day crisis, marked by the inflow of refugees and increase in populism? The seriousness of the crises demands efforts of active toleration, acceptance, and integration of refugees and the like. Active toleration brings with itself a series of very demanding duties, divided into immediate ones involving immediate Samaritan aid to people at our doors and the long-term ones involving their acculturation and possibilities of decent life for them. A cosmopolitan attitude can contribute a lot. In the context of a refugee crisis, cosmopolitanism is not disappearing but showing its non-traditional, more Samaritan face turned not to distant strangers, as the classical one, but towards strangers at our doors.We have conjectured that this work of active toleration can diminish the need for the passive one: the well-integrated immigrant is no longer seen as a strange, exotic person with an incomprehensible and unacceptable attitude, but as one of us so that her attitudes become less irritating and provocative. The social-psychological approach that sees integration as involving both the preservation of central aspects of the original identity and the copy-pasting of the new one over it offers an interesting rationale for the conjecture: once integrated, the former newcomer is perceived as one of ‘us’ and her views stop being exotic, incomprehensible and a priori unacceptable. Given the amount of need for toleration, and difficulties and paradoxes connected with its passive variety, the conjecture, if true, might be a piece of good news.Finally, we have briefly touched the question of deeper causes of the crisis. Once one turns to this question, the traditional cosmopolitan issues come back to the forefront: the deep poverty and unjust distribution on the one hand, and conflicts and wars on the other. Cosmopolitans have a duty to face these issues, and this is where active global toleration leads in our times.

Neuropsychological Investigations of Human Amnesia: Insights Into the Role of the Medial Temporal Lobes in Cognition

2017 ◽  
Vol 23 (9-10) ◽  
pp. 732-740 ◽  
Author(s):  
Mieke Verfaellie ◽  
Margaret M. Keane
Keyword(s):  
Long Term Memory ◽  
Medial Temporal Lobes ◽  
Theoretical Understanding ◽  
Temporal Lobes ◽  
The Past ◽  
Clinical Disorders ◽  
Nuanced Understanding ◽  
The One

AbstractThe past 30 years of research on human amnesia has yielded important changes in our understanding of the role of the medial temporal lobes (MTL) in memory. On the one hand, this body of evidence has highlighted that not all types of memory are impaired in patients with MTL lesions. On the other hand, this research has made apparent that the role of the MTL extends beyond the domain of long-term memory, to include working memory, perception, and future thinking. In this article, we review the discoveries and controversies that have characterized this literature and that set the stage for a new conceptualization of the role of the MTL in cognition. This shift toward a more nuanced understanding of MTL function has direct relevance for a range of clinical disorders in which the MTL is implicated, potentially shaping not only theoretical understanding but also clinical practice. (JINS, 2017, 23, 732–740)

scholarly journals Digital Maturity of HR in SMEs

2020 ◽  
Vol 6 (1) ◽  
pp. 56
Author(s):  
Georg Thomas
Keyword(s):  
Financial Resources ◽  
Full Potential ◽  
Hr Management ◽  
It Systems ◽  
Points Of View ◽  
Similar Vein ◽  
The One ◽  
Transformation Processes

Digitalization and digital transformation processes pose chances and challenges to companies in a variety of different aspects. The present paper focuses on the digitalization of HR management in SMEs. The situation if discussed both in the light of SMEs, who are faced with unique challenges in terms of digitalization and its subsequent management. The role of the entrepreneurs/head of SMEs in driving the digitalization process is discussed. In a similar vein, the role HR departments can take both in their own digitalization and in the one of the company is displayed from various points of view, citing evidence that HR departments – especially of SMEs – often lag behind in terms of digitalization, thus not living up to their full potential as internal service partners of companies. An empirical study based on a quantitative survey explored these challenges further. A total of n = 16 experts from HR departments of German SMEs assessed the digital maturity of their own departments. The results show that – in accordance with the findings derived from the literature – HR departments are still struggling with digitalization, barely making use of their data and not connecting yet to other IT systems within the company. Most experts describe the role of their departments as reactive instead of active. These findings are discussed in the light of studies on digital maturity, showing that the situation in Germany/Central Europe for SMEs and their HR departments is a complex one: On the one hand it seems clear, that digitalization can help the companies and departments on a long-term perspective – which, according to some findings, is also well-known to the executives. At the same time, HR departments typically lack the (financial) resources and the involvement to actively work on their digital strategy.

scholarly journals Forest, forest, forest. Sometimes we sleep. Walking, sleep, walking, sleep. It’s dangerous on this way

2021 ◽  
Vol 51 (44) ◽  
pp. 204-221
Author(s):  
Marijana Hameršak ◽  
Iva Pleše
Keyword(s):  
Field Research ◽  
The Other ◽  
Border Control ◽  
Exclusionary Policies ◽  
The One ◽  
External Interventions ◽  
Place And Route ◽  
Term Field

Hidden migrant routes through Croatia lead through forest areas (among other types of terrain) which include those along state borders, but also forests in the interior of the territory. Those forests can variously be seen as shelters for migrants, albeit harsh, or as green tunnels leading to desired destinations, and as scenes of suffering and violence. This article approaches the forests in question as landscapes that have been transformed from a neutral natural environment into active factors for creating and maintaining border control regimes and deterring and expelling unwanted migrants. Based on our long-term field research and publicly available (archival, media and other) sources, we seek to document, interpret, and interconnect the objects and practices involved in constructing the forest as a hostile terrain and perilous environment for migrants, and as an important element in controlling unwanted migrations. These are, on the one hand, objects and practices that intervene into forests, such as setting up cameras or cutting down trees, and, on the other, interventions that take place in forests, such as police interception or expulsion. Apart from these external interventions, in this context of remodeling forests into dangerous environments, one can also discuss the role of nature itself and its characteristics, as well as the causes of why migrants find themselves in nature in the first place. Although, at first glance, it seems that people on the move choose the forest as the place and route of their movement of their own volition, they are pushed and expelled into these forests by exclusionary policies (visa regimes, asylum systems, etc.). This, ultimately, classifies forests in Croatia as weaponized landscapes of exclusion and death, such as the desert (e.g., De León 2015), mountain (Del Biaggio et al. 2020), maritime (e.g., Albahari 2015) or archipelago (Mountz 2017) landscapes

The Role of Benchmarking in Managerial Performance

2018 ◽  
Vol 9 (4) ◽  
pp. 37-47
Author(s):  
Alina Stanciu ◽  
Ana-Maria Ifrim
Keyword(s):  
Cost Effectiveness ◽  
Customer Satisfaction ◽  
The Other ◽  
Management Theory ◽  
Financial Resources ◽  
Quality Cost ◽  
Managerial Performance ◽  
The One

Benchmarking is one of the methods of widespread use in practice and in management theory, benefiting from continuous development. This article intends to identify and analyze the perspective of benchmarking in romanian smes from the perspective of quality, cost, effectiveness, and customer satisfaction. The results show that for many romanian organizations, benchmarking is still a little overlooked, on the one hand because of the lack of necessary financial resources, on the other hand, of a poor awareness of the importance of these investments in the medium and long term.

scholarly journals Anthophyllite Asbestos: The Role of Fiber Width in Mesothelioma Induction Part 1: Epidemiological Studies of Finnish Anthophyllite Asbestos

2017 ◽  
Vol 7 (1) ◽  
pp. 9
Author(s):  
Edward B. Ilgren ◽  
John A. Hoskins
Keyword(s):  
Fiber Diameter ◽  
Important Determinant ◽  
Epidemiological Studies ◽  
High Dose ◽  
Fibre Width ◽  
Mineral Fibre ◽  
Amphibole Asbestos ◽  
The One

Anthophyllite asbestos only occurs in a few parts of the world in sufficient quantities to be mined. The largest deposits of anthophyllite asbestos occur in Finland where it was mined for more than 75 years and very extensively used and distributed, anciently, for more than six millennia. Anthophyllite is one of the five minerals known collectively as amphibole asbestos. Studies of the effect of these five mineral fibre types when inhaled have shown that fibre width is an important determinant of mesothelioma induction. Only the “thinner” fibres or those with fiber diameter dimensional profiles predominantly less than 0.25 – 0.30 µm, are clearly mesotheliogenic. The “thicker” ones or those whose predominant widths are greater than these diameters do not appear to show an observable attendant risk of mesothelioma. Observations based on studies of at least, two “thick” forms of amphibole asbestos support these hypotheses. The one is Bolivian crocidolite; the other Finnish anthophyllite. The Finnish anthophyllite industry presents an important opportunity to study the robustness of the theory that fibre width is key to mesothelioma genesis as vast numbers of people in all sectors of the Finnish industry and their families have historically incurred massive fiber exposures sufficient to cause a gross excess of asbestosis. Nonetheless, in spite of these long term, high dose exposures clear evidence for a mesothelioma risk due to anthophyllite asbestos is still lacking.

The Role of Magnesium in Blood Coagulation

1967 ◽  
Vol 18 (03/04) ◽  
pp. 626-633 ◽  
Author(s):  
I Szelényi ◽  
J Rigô ◽  
B. O Ahmed ◽  
J Sos
Keyword(s):  
Blood Coagulation ◽  
Blood Platelets ◽  
Saturated Fat ◽  
Functional Importance ◽  
Long Term Experiments ◽  
Cellular Oxidation ◽  
The One ◽  
Physiological Type

SummaryHypercoagulative tendencies elicited by saturated fat could be repressed by oral or venous administration of magnesium in acute as well as in long term experiments.Magnesium appears to have double functional importance in coagulation : On the one hand, it exerts direct influence by antagonizing calcium, promoting fibrinolysis, and stabilizing fibrinogen and blood platelets and, on the other hand, it acts indirectly as well in that it causes vasodilatation and favours cellular oxidation.In the dynamic equilibrum of the processes taking part in blood coagulation magnesium appears to play its role as a physiological type of anticoagulant.

scholarly journals Het Europa van de opportunities : Analyse van de overlevingsstrategie van de christen-democraten in de Europese Unie

Res Publica ◽  
2003 ◽  
Vol 45 (4) ◽  
pp. 651-672
Author(s):  
Steven Van Hecke
Keyword(s):  
Political Leadership ◽  
Survival Strategy ◽  
People's Party ◽  
New Member States ◽  
European People’S Party ◽  
Relative Decline ◽  
Democratic Parties ◽  
The One

While Christian Democratic parties in several Western European countries are often said to be in crisis, the European People's Party holds the largest parliamentary group in the European Parliament since 1999. This paradox relies on the specificity of the different 'national' electoral logics on the one hand and the realisation of a long-term 'European' majority strategy on the other hand. The alliance with Conservatives and Conservative parties has to overcome an absolute electoral decline in 'old' EU countries and a relative decline through the accession of 'new' member states without Christian Democratic parties.  The EPP majority strategy is realised through various ways : the key position of the transnational party and party group, the role of political leadership, the way of decision making, the co-operation with side-organisations, the problem-solving of ideological conflicts, etc. Our analysis proves how the majority strategy of the European Christian Democrats realises its ultimate 'survival strategy' despite (or thanks to) several nationalparty crises.

scholarly journals The Eternal Peasant and the Timeless Village. Archaeology and Ideologies of the Past

2020 ◽  
Vol 38 (2) ◽  
pp. 43-73
Author(s):  
Rainer Schreg
Keyword(s):  
Rural Life ◽  
13Th Century ◽  
Rural History ◽  
The Past ◽  
History Of Research ◽  
History Of ◽  
Historical Role ◽  
The One

The perspectives on the medieval village and on the historical role of peasants have changed throughout the history of research. Traditional views on history saw rural life as unchangeable and therefore presumed that villages were rooted in the migration period. Modern research recognised the formation of the medieval village as a complex long-term process that, depending on the region, culminated in the 11th – 13th century. This paper takes a closer look at the situation in southwestern Germany, analysing research history on the one hand and selected episodes of medieval rural history on the other. The paper suggests that due to traditional views on the structure of history, peasants’ agency has been undervalued.  

scholarly journals Simulation centre as a strategic instrument of medical education quality improvement

2019 ◽  
Vol 2019 (2 (127)) ◽  
pp. 76-79
Author(s):  
Khachatryan Robert ◽  
Ashot Avagimyan
Keyword(s):  
Medical Education ◽  
New Technologies ◽  
Educational Institution ◽  
The Times ◽  
The One ◽  
Simulation Centre ◽  
Medical University

In the 21st century, medicine alongside with medical education, is a dynamically developing industry, and is experiencing a real renaissance of its development. New technologies are gradually replacing the old methods, which undoubtedly increases the quality of provided services, reducing the probability of medical errors, and favourably affects the mortality rate (for example, echocardiography, both transthoracic and intra-oesophageal, has replaced percussion and heart palpation). However, relatively old methods, for example, such as auscultation of the heart, still do not lose their significance or effectiveness, in particular, it is worth noting the high information content of this instrumental examination when dealing with valvular pathologies of the heart (for example, critical aortic stenosis). It is known that any educational institution, in particular, a medical one, must keep abreast of the times and correspond to modern needs. The management of medical universities, making long-term strategies for their development, in order to increase competitiveness, both their own and the one of their students, should maximally provide their clinics with the latest equipment, which will undoubtedly allow preserving its niche, perhaps at the regional or world level. For example, the Yerevan State Medical University named after Mkhitar Heratsi is of inter-regional importance, being the leading medical educational institution among the countries of the Caucasus and the Anterior Asia. In the process of introducing new technologies among students of medical universities, a competence-based approach is the opening of highly equipped imulation centres, where the future doctor and/or a certain doctor will be given a unique in the medical world chance, a chance for error, since it is well-known that a doctor’s mistake can cost life of the whole people. This article is devoted to the pivotal role of the simulation centre within the modern educational system of medical universities as well as the strategy for its construction. Keywords: medical education, doctor, simulation centre.

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