scholarly journals Interrelationships in trace-element metabolism in metal toxicities in a cobalt-resistant strain of Neurospora crassa

1973 ◽  
Vol 132 (4) ◽  
pp. 673-680 ◽  
Author(s):  
G. Venkateswerlu ◽  
K. Sivarama Sastry
Keyword(s):  
Neurospora Crassa ◽  
Trace Element ◽  
Iron Metabolism ◽  
Resistant Strain ◽  
Parent Strain ◽  
Resistance Mutation ◽  
Mechanism Of Resistance ◽  
Trace Element Metabolism ◽  
High Concentrations ◽  
Toxic Concentrations

A strain of Neurospora crassa was isolated by training the mould to grow on media containing high concentrations of Co2+. This strain, the CoR strain, exhibited approximately tenfold the resistance of the parent strain to Co2+ and Ni2+ but not to Zn2+ or Cu2+. Co2+ toxicity in the CoR strain was reversed by Mg2+ but not by Fe3+. Also, Co2+ did not affect iron metabolism in this strain. It is suggested that the mechanism of resistance in the CoR strain involves an alteration in the pattern of iron metabolism such that the latter is no longer adversely affected by toxic concentrations of Co2+. The CoR strain is genetically stable and is most probably a result of a resistance mutation in N. crassa induced by Co2+.

scholarly journals Interrelationships in trace-element metabolism in metal toxicities in Neurospora crassa

1962 ◽  
Vol 85 (3) ◽  
pp. 486-491 ◽  
Author(s):  
KS SASTRY ◽  
PR ADIGA ◽  
V VENKATASUBRAMANYAM ◽  
PS SARMA
Keyword(s):  
Neurospora Crassa ◽  
Trace Element ◽  
Trace Element Metabolism

scholarly journals The effect of copper excess on iron metabolism in sheep

1978 ◽  
Vol 170 (1) ◽  
pp. 137-143 ◽  
Author(s):  
E C Theil ◽  
K T Calvert
Keyword(s):  
Iron Metabolism ◽  
Iron Concentration ◽  
Transferrin Saturation ◽  
Fold Increase ◽  
Copper Treatment ◽  
Excess Copper ◽  
High Concentrations ◽  
Copper Excess ◽  
Effect Of Copper ◽  
Haemoglobin Content

Sheep were treated with large amounts of copper (20 mg of CuSO4,5H2O/kg body wt. per day) for 9 weeks to examine the effect of copper excess on iron metabolism. In addition to confirming that massive haemolysis and accumulation of copper occurs in the liver, kidney and plasma after 7 weeks of exposure to excess copper, it was observed that excess copper produced an increased plasma iron concentration and transferrin saturation within 1 week. Further, iron preferentially accumulated in the spleen between 4 and 6 weeks of copper treatment, producing 3-fold increases in the iron content of both the ferritin and non-ferritin fractions. A 3-4 fold increase was also observed in the amount of ferritin that could be isolated from the spleen. The copper treatment had little or no effect on the concentration of iron in the liver and bone marrow. The following properties of erythrocytes were also unaffected by copper treatment: size, haemoglobin content and pyruvate kinase activity, although the erythrocyte concentration of copper increased after 6 weeks. Copper accumulated in the spleen between 6 and 9 weeks, probably owing to the phagocytosis of erythrocytes containing high concentrations of copper. The data suggest that copper excess influences iron metabolism, initially by causing a compensated haemolytic anaemia, and later by interfering with re-utilization of iron from ferritin in the reticuloendothelial cells of the spleen.

Inorganic Bromide in Higher Fungi

1984 ◽  
Vol 39 (9-10) ◽  
pp. 863-866 ◽  
Author(s):  
T. Stijve
Keyword(s):  
Trace Element ◽  
Dry Weight ◽  
Mean Value ◽  
Inorganic Salts ◽  
Chromatographic Methods ◽  
The Mean ◽  
High Concentrations

Abstract A total of 138 samples of higher fungi, representing 35 species (15 belonging to the genus Amanita), were analysed for the trace element bromine using spectrophotometric and gas chromatographic methods. High concentrations of bromine, up to 100 mg/kg on dry weight, were encountered in Amanitaceae, especially in members of the subsections Phalloideae and Eu-Amanita, whereas in other fungi the mean value for this element was only 3,3 m g/kg. Some bromine-accumulating Amanitas also contained unusually high chlorine levels. Am axi­mum concentration of 3 percent on dry weight was measured in A. phalloides. It could be demonstrated that most, if not all of bromine and chlorine was present in the fungi as ionisable inorganic salts. Two organochlorine metabolites, previously reported in some mushrooms, were absent in A. phalloides and A. muscaria.

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