scholarly journals Studies on glycolysis in the dog kidney in vivo

1972 ◽  
Vol 128 (3) ◽  
pp. 80P-81P
Author(s):  
J Costello ◽  
J M Scott ◽  
P Wilson ◽  
E Bourke
Keyword(s):  
Dog Kidney

Interrelations of arsenate and phosphate transport in the dog kidney

1963 ◽  
Vol 205 (4) ◽  
pp. 707-714 ◽  
Author(s):  
J. M. Ginsburg ◽  
W. D. Lotspeich
Keyword(s):  
Phosphate Transport ◽  
Tubular Secretion ◽  
Tubular Reabsorption ◽  
Urine Flow ◽  
Phosphate Concentration ◽  
Plasma Phosphate ◽  
Osmotic Diuresis ◽  
Competitive Mechanism ◽  
Dog Kidney

The relation between arsenate and phosphate transport in the dog kidney was studied by measuring the renal clearance of arsenate labeled with its radioactive isotope As74. The experiments were performed during osmotic diuresis induced by mannitol. The results demonstrate certain similarities in the transport of these ions. Arsenate undergoes a net tubular reabsorption which is inhibited as the plasma phosphate concentration is raised. The inverse relationship between arsenate transport and the plasma As:P ratio suggests a competitive mechanism for the interaction between the two ions Like phosphate, arsenate transport is inhibited by glucose and this effect is reversed by phlorizin. An important difference between arsenate and phosphate transport is the sensitivity of arsenate transport to urine flow. In vivo reduction of arsenate to arsenite and a net tubular secretion of arsenite has been observed. The results are discussed in terms of the known ability of arsenate to substitute for phosphate in biochemical reactions.

Mechanism of maleic acid-induced glucosuria in dog kidney

1976 ◽  
Vol 231 (4) ◽  
pp. 1024-1032 ◽  
Author(s):  
M Silverman ◽  
L Huang
Keyword(s):  
Brush Border ◽  
Maleic Acid ◽  
Brush Border Membrane ◽  
Multiple Indicator Dilution ◽  
Dog Kidney ◽  
Proximal Tubular ◽  
Multiple Indicator ◽  
Prior Administration

The multiple indicator-dilution technique in vivo and isolated brush-border membranes in vitro have been used to explore the mechanism of maleic acid-induced glucosuria in dog kidney. The interaction of D-glucose with the antiluminal membrane from the peritubular fluid surface is unaltered. It is demonstrated that alpha-methyl-D-glucoside (alpha MG) enters and exits from the proximal tubular cell only across the brush-border membrane. Then using alphaMG as a reference indicator, it is shown that maleic acid does not cause complete inhibition of D-glucose interaction with the antiluminal membrane from the cytoplasmic surface. The binding of [3H]phlorizin both in vivo and in vitro is not affected by prior administration of maleic acid, indicating that D-glucose interaction with the outside surface of the brush border is also not affected by maleic acid. The data are therefore consistent with the concept that maleic acid-induced glucosuria is due either to i) partial inhibition of D-glucose movement from cytoplasm across the antiluminal membrane into the blood, ii) stimulated movement back across the brush-border membrane into urine, or iii) a combination of the two effects.

scholarly journals Glucose Utilization and Production by the Dog Kidney In Vivo in Metabolic Acidosis and Alkalosis

1973 ◽  
Vol 52 (3) ◽  
pp. 608-611 ◽  
Author(s):  
J. Costello ◽  
J. M. Scott ◽  
P. Wilson ◽  
E. Bourke
Keyword(s):  
Metabolic Acidosis ◽  
Glucose Utilization ◽  
Dog Kidney

Comparative effects of phlorizin and phloretin on glucose transport in the cat kidney

1962 ◽  
Vol 203 (6) ◽  
pp. 975-979 ◽  
Author(s):  
Stephen S. Chan ◽  
William D. Lotspeich
Keyword(s):  
Blood Glucose ◽  
Glucose Transport ◽  
Renal Tubule ◽  
Tubular Reabsorption ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dog Kidney ◽  
Glucose Carrier

The net tubular reabsorption of glucose (TG) was measured simultaneously in both kidneys of the cat before, during, and after the infusion of small amounts of phlorizin and phloretin at constant rates into one renal artery. Experiments were performed at endogenous and elevated blood glucose levels. The results show that phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10–5 to 10–7 m. These estimates agree with those for dog kidney in vivo and hamster small intestine in vitro. In addition to this high affinity of phlorizin for the tubular glucose carrier, the experiments also reveal the easily dissociable nature of the phlorizin carrier complex. When blood glucose is elevated the TG is even more sensitive to small concentrations of phlorizin. At all blood glucose levels the aglucone, phloretin, is at least ten times less effective in inhibiting TG than phlorizin itself. These findings are discussed in relation to critical groupings in the phlorizin molecule.

Interaction between prostaglandin E2 and leukotriene D4 on the excretion of electrolytes by the dog kidney in vivo

1987 ◽  
Vol 33 (2) ◽  
pp. 301-313 ◽  
Author(s):  
R.L. Hébert ◽  
C. Lamoureux ◽  
P. Sirois ◽  
P. Braquet ◽  
G.E. Plante
Keyword(s):  
Prostaglandin E2 ◽  
Leukotriene D4 ◽  
Dog Kidney

The Metabolic Fates of Palmitate in the Dog Kidney in vivo

Nephron ◽  
1971 ◽  
Vol 8 (5) ◽  
pp. 488-499 ◽  
Author(s):  
M. Barac-Nieto ◽  
J.J. Cohen
Keyword(s):  
Dog Kidney

scholarly journals Regulation of glutamine metabolism in dog kidney in vivo

1986 ◽  
Vol 29 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Patrick Vinay ◽  
Guy Lemieux ◽  
André Gougoux ◽  
Mitchell Halperin
Keyword(s):  
Glutamine Metabolism ◽  
Dog Kidney

Effect of chronic alkalosis and acidosis on glutaminase II path in the dog kidney in vivo

1971 ◽  
Vol 220 (4) ◽  
pp. 1033-1036 ◽  
Author(s):  
E Bourke ◽  
G Frindt ◽  
D Rubio-Paez ◽  
GE Schreiner
Keyword(s):  
Dog Kidney
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