scholarly journals Carnitine and brown adipose tissue metabolism in the rat during development

1972 ◽  
Vol 127 (1) ◽  
pp. 107-111 ◽  
Author(s):  
P. Hahn ◽  
J. Skala
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Adaptation ◽  
Carnitine Palmitoyltransferase ◽  
Carnitine Acetyltransferase ◽  
Total Acid ◽  
Adipose Tissue Metabolism ◽  
Acetyltransferase Activity ◽  
Brown Adipose ◽  
Old Rats

1. The content of carnitine, acylcarnitine and total acid soluble carnitine in brown adipose tissue of rats increases rapidly after birth, attaining a peak on about day 10 and then decreases. Similar changes with age were found for carnitine acetyltransferase activity in mitochondria from brown adipose tissue and heart. The activity of this enzyme in brain and in liver is much smaller, but also increases postnatally. 2. The activity of carnitine palmitoyltransferase in brown adipose tissue, however, decreases after birth then increases later in life. 3. Exposure of 18-day-old rats to the cold for 20 days leads to an increase in carnitine content in brown adipose tissue and raises the activity of carnitine acetyltransferase. The activity of carnitine palmitoyltransferase is not affected by cold adaptation.

The Effects of Thyroxine and Isopropylnoradrenaline on Cytochrome Oxidase Activity in Brown Adipose Tissue

1973 ◽  
Vol 51 (10) ◽  
pp. 751-758 ◽  
Author(s):  
H. M. C. Heick ◽  
C. Vachon ◽  
Mary Ann Kallai ◽  
Nicole Bégin-Heick ◽  
J. LeBlanc
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Protein Content ◽  
Cytochrome Oxidase ◽  
Cold Adaptation ◽  
Metabolic Response ◽  
Mitochondrial Enzymes ◽  
Cold Adapted ◽  
Brown Adipose ◽  
Hormonal Treatments

Groups of animals were treated with injections of isopropylnoradrenaline, thyroxine, or both hormones together. The effects of these hormonal treatments on the size, protein content, and level of some mitochondrial enzymes, in particular the cytochrome oxidase, were determined and compared to the effect on these parameters produced by cold adaptation. The changes observed were correlated with the resistance of the animals to cold stress and with their metabolic response to injections of isopropylnoradrenaline. All treatments increased the size of the brown adipose tissue. Whereas thyroxine had little effect on the protein content and cytochrome oxidase, both isopropylnoradrenaline and cold adaptation produced increases in these parameters. It appears that the isopropylnoradrenaline-treated animals mimic more closely the cold-adapted animals than do those with thyroxine treatment. However, the isopropylnoradrenaline-treated animals are not as resistant to cold as the cold-adapted animals.

Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalectomy

1987 ◽  
Vol 253 (2) ◽  
pp. E149-E157
Author(s):  
H. K. Kim ◽  
D. R. Romsos
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
High Fat Diet ◽  
High Fat ◽  
Adipose Tissue Metabolism ◽  
High Carbohydrate ◽  
Bat Mitochondria ◽  
Norepinephrine Turnover ◽  
Brown Adipose ◽  
Thermogenic Capacity

Adrenalectomy prevents development of obesity in ob/ob mice fed high-carbohydrate stock diets partly by stimulating the low thermogenic capacity of their brown adipose tissue (BAT). Adrenalectomy, however, fails to prevent development of obesity in ob/ob mice fed a high-fat diet. Effects of adrenalectomy on BAT metabolism in ob/ob mice fed a high-fat diet were thus examined. ob/ob mice fed the high-fat diet developed gross obesity despite normal BAT metabolism, as assessed by rates of norepinephrine turnover in BAT, GDP binding to BAT mitochondria, and GDP-inhibitable, chloride-induced mitochondrial swelling. Adrenalectomy failed to arrest the development of obesity or to influence BAT metabolism in ob/ob mice fed the high-fat diet. Development of obesity in ob/ob mice fed a high-fat diet is not associated with low thermogenic capacity of BAT or with adrenal secretions, as it is in ob/ob mice fed high-carbohydrate stock diets.

Effects of stanniocalcin hormones on rat brown adipose tissue metabolism under fed and fasted conditions

2019 ◽  
Vol 485 ◽  
pp. 81-87 ◽  
Author(s):  
Elaine Sarapio ◽  
Samir Khal Souza ◽  
Everton Lopes Vogt ◽  
Débora Santos Rocha ◽  
Rafael Bandeira Fabres ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Brown Adipose

scholarly journals Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes

2017 ◽  
Vol 39 ◽  
pp. 101-109 ◽  
Author(s):  
Mandana Pahlavani ◽  
Fitia Razafimanjato ◽  
Latha Ramalingam ◽  
Nishan S. Kalupahana ◽  
Hanna Moussa ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Eicosapentaenoic Acid ◽  
Brown Adipose Tissue ◽  
High Fat ◽  
Brown Adipocytes ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Brown Adipose

Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective

2020 ◽  
Vol 20 (9) ◽  
Author(s):  
Andrea Mendez-Gutierrez ◽  
Francisco J. Osuna-Prieto ◽  
Concepcion M Aguilera ◽  
Jonatan R Ruiz ◽  
Guillermo Sanchez-Delgado
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Brown Adipose

A critical appraisal of brown adipose tissue metabolism in humans

2015 ◽  
Vol 10 (3) ◽  
pp. 259-280 ◽  
Author(s):  
Denis P Blondin ◽  
Sébastien M Labbé ◽  
Eric E Turcotte ◽  
François Haman ◽  
Denis Richard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Critical Appraisal ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Brown Adipose
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