scholarly journals The effect of glycols on the renaturation of soluble collagen

1971 ◽  
Vol 125 (4) ◽  
pp. 1069-1074 ◽  
Author(s):  
D. R. Cooper ◽  
A. E. Russell ◽  
G. J. Hart
Keyword(s):  
Optical Rotation ◽  
Fixed Time ◽  
Native Protein ◽  
Fixed Temperature ◽  
Recovery Rates ◽  
Skin Collagen ◽  
Initial Recovery ◽  
The Relationship ◽  
Kinetics Of ◽  
Calf Skin

The effects of a number of related glycols and substituted glycols on the renaturation kinetics of acid-soluble calf-skin collagen have been investigated. Optical rotation recovery was monitored at a fixed temperature in the presence of perturbants and the initial rates of reaction were determined. The effects of perturbants on stability of the native protein are compared with their action in the renaturing systems. The relationship between initial recovery rates and fixed-time [α]-values is shown to be dependent upon the renaturation temperature. The influence of perturbant concentration on recovery rates is discussed in terms of present theories of the mechanism of collagen renaturation.

scholarly journals The effect of ultraviolet irradiation on soluble collagen

1965 ◽  
Vol 97 (1) ◽  
pp. 139-147 ◽  
Author(s):  
DR Cooper ◽  
RJ Davidson
Keyword(s):  
Ultraviolet Irradiation ◽  
Optical Rotation ◽  
Gel Filtration ◽  
Collagen Molecule ◽  
Neutral Salt ◽  
Soluble Collagen ◽  
Acid Soluble Collagen ◽  
Skin Collagen ◽  
Kinetics Of ◽  
Calf Skin

1. The effect of ultraviolet irradiation on acid-soluble and neutral-salt-soluble calf-skin collagen was studied by chromatography, gel filtration, amino acid analysis and sedimentation of the sub-units, and the reaction kinetics of degradation were obtained from viscosity and optical rotation measurements. 2. It was demonstrated that, whereas the structure of neutral-salt-soluble calf-skin collagen may be represented by the formula (alpha(1))(2)alpha(2), the acid-soluble extract has the formula alpha(1).(alpha(2))(2). The acid-soluble collagen is also unusual in containing a large amount of a component that could be beta(22). 3. Ultraviolet irradiation causes the progressive degradation of the collagen molecule into smaller molecular fragments that subsequently lose their helical nature. The rate constants show that the denaturation of soluble collagens by ultraviolet irradiation is much slower, under the conditions used, than denaturation by heat or enzymes.

Microprocessor Architecture Era for Development Cloud Computing of Ministry of Electricity and Energy of Egypt

2014 ◽  
Vol 13 (12) ◽  
pp. 5199-5209
Author(s):  
Heba A. El-Khobby ◽  
Mostafa M. AbdElnaby ◽  
Abdel-Aziz Ibrahim Mahmoud HASSANIN ◽  
Abdallah D. Maziad
Keyword(s):  
Information Technology ◽  
Cloud Computing ◽  
Theoretical Analysis ◽  
Organization Structure ◽  
Fixed Time ◽  
Organization Structures ◽  
Competence Evaluation ◽  
Competency Based ◽  
Services Evaluation ◽  
The Relationship

A development and evaluation the Cloud Computing (ClComp) of Ministry of Electricity and Energy of Egypt (MEEE) is presented in this paper. In order to be able to judge whether the ClComp of MEEE is competence, there is a need to develop criteria which performance can judged. Competency based standards and the ability to perform the activities within an occupation to the standard expected in the organization structure are presented. The key objective of Cloud Computing is to integrate Authorized Groups (AuthGs) development with the needs of the organization structures of MEEE. The ClComp of MEEE was developed jointly between the telecommunication information technology and ClComp services. Evaluation enables participant to distinguish between AuthGs centered view and a customer centered view of cloud computing of MEEE is competence evaluation. Recognize the main types of evaluation, explain the purpose of evaluation compare the approaches to cloud computing evaluation and review the relationship between the process and policy of evaluation are investigated. Microprocessor architecture presented an optimistic view of multicore scalability to develop the ClComp. Moreover this paper investigates the theoretical analysis of multiprocessor developing and scalability. The analysis was based on the laws of Amdahl's, Gustafson's, Hill's and Marty for fixed-workload condition. Moreover, challenged the difficulties to develop better cloud computing is taken into account. Also, multicore analysis of ClComp scalability, performance and power under fixed-time and memory-bound conditions are studied. These results complement existing studies and demonstrate that ClComp architectures are capable of extensive scalability and developing.

Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. (Preprint)

2020 ◽  
Author(s):  
Yue-Cune Chang
Keyword(s):  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Recovery Rates ◽  
Bcg Vaccination ◽  
The World ◽  
New Form ◽  
The Relationship ◽  
Disease Specific

BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection. OBJECTIVE Our findings confirm that the BCG vaccination might protect against COVID-19 virus infection. METHODS Data of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries’ mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates. RESULTS Among those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively. CONCLUSIONS That data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.06.14.20131268

Polarographic studies on renaturation of urea-denatured human serum albumin

1989 ◽  
Vol 54 (2) ◽  
pp. 536-543 ◽  
Author(s):  
Josef Chmelík ◽  
Pavel Anzenbacher ◽  
Vítěz Kalous
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Irreversible Process ◽  
State Model ◽  
Native Protein ◽  
Main Components ◽  
Two State Model ◽  
Kinetics Of

The renaturation of the two main components of human serum albumin, i.e. of mercaptalbumin and nonmercaptalbumin, was studied polarographically. It has been demonstrated that renaturation of both proteins after 1-min denaturation in 8M urea is reversible. By contrast, renaturation after 200 min denaturation in 8M urea is an irreversible process; the characteristics of renatured mercaptalbumin differ more from the properties of the native protein than the characteristics of nonmercaptalbumin. The studies of the kinetics of renaturation of both proteins have shown that the renaturation can be represented by a two-state model. This means that the existence of stable intermediary products during the renaturation process was not determined polarographically.

scholarly journals The Location of Cross-links in γ Chains from Calf Skin Collagen

1968 ◽  
Vol 243 (11) ◽  
pp. 2890-2898
Author(s):  
M P Drake ◽  
P F Davison
Keyword(s):  
Skin Collagen ◽  
Cross Links ◽  
Calf Skin

Oxidation of Olefins Representing Some Structural Units of GR-S

1952 ◽  
Vol 25 (1) ◽  
pp. 21-32 ◽  
Author(s):  
W. C. Warner ◽  
J. Reid Shelton
Keyword(s):  
Phenyl Group ◽  
Kinetic Mechanism ◽  
Oxidation Reactions ◽  
Chain Reaction ◽  
Instantaneous Rate ◽  
Initial Oxygen ◽  
Oxidation Of Olefins ◽  
A Minor ◽  
The Relationship ◽  
Kinetics Of

Abstract Three olefins were oxidized in the liquid phase with molecular oxygen to determine the kinetics of the oxidation reactions and the relationship to oxidation of rubber. The instantaneous rate of oxidation was found to be related to the analytically determined olefin and peroxide concentrations by the equation : Rate=k (unreacted olefin)(peroxide), where rate equals moles of oxygen per mole of original olefin per hour and the parentheses represent molarities. Presence of a phenyl group was found to affect k, but only in a minor way, indicating that the same fundamental kinetic mechanism applies in both aromatic and aliphatic olefins. The data are consistent with the general kinetic mechanism of Bolland involving oxygen attack at the alpha-methylenic group. However, it appears probable that initial oxygen attack can also occur at the double bond, resulting in the formation of a peroxide biradical, which may then react with other olefin molecules, initiating the usual chain reaction mechanism.

CORRELATION BETWEEN ELECTRIC CHARGING OF THE SAMPLE SURFACE AND KINETICS OF OPTICALLY STIMULATED EXOELECTRON EMISSION (OSEE) FROM CRYOSOLIDIFIED NaCl SOLUTION

1990 ◽  
Vol 04 (03) ◽  
pp. 201-209
Author(s):  
A. GIEROSZYŃSKI
Keyword(s):  
Electric Fields ◽  
Surface Potential ◽  
Surface Region ◽  
Sample Surface ◽  
Exoelectron Emission ◽  
Nacl Solution ◽  
Emitter Surface ◽  
Emitter Layer ◽  
The Relationship ◽  
Kinetics Of

It was found that OSEE kinetics from electron bombarded cryosolidified NaCl solution, depend on electric charging of the sample surface. It was shown that from the relationship between the maximum surface potential and the parameters of OSEE kinetic, intensities of electric fields in the emitter layer could be estimated. It is supposed that nonhomogeneous electric fields existing in the emitter surface region, influence the emission levels responsible for the course of OSEE kinetics.

scholarly journals The Viscometric Behavior of Solubilized Calf Skin Collagen at Low Rates of Shear

1966 ◽  
Vol 241 (8) ◽  
pp. 1784-1789
Author(s):  
Leo D. Kahn ◽  
Lee P. Witnauer
Keyword(s):  
Skin Collagen ◽  
Calf Skin
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