scholarly journals The role of thiol groups in the multiple forms of an invertebrate creatine kinase

1970 ◽  
Vol 119 (3) ◽  
pp. 9P-10P
Author(s):  
M D Doherty ◽  
J A E Fitzsimmons
Keyword(s):  
Creatine Kinase ◽  
Thiol Groups ◽  
Multiple Forms

scholarly journals The Struggle Against Torture: Challenges, Assumptions and New Directions

2019 ◽  
Vol 11 (2) ◽  
pp. 324-333
Author(s):  
Tobias Kelly
Keyword(s):  
Human Rights ◽  
Multiple Forms ◽  
Marginalized Groups ◽  
Current State ◽  
New Directions ◽  
History Of ◽  
Emerging Themes ◽  
Short Essay ◽  
Forms Of Violence

Abstract This short essay offers a broad and necessarily incomplete review of the current state of the human rights struggle against torture and ill-treatment. It sketches four widespread assumptions in that struggle: 1) that torture is an issue of detention and interrogation; 2) that political or security detainees are archetypal victims of torture; 3) that legal reform is one of the best ways to fight torture; and 4) that human rights monitoring helps to stamp out violence. These four assumptions have all played an important role in the history of the human rights fight against torture, but also resulted in limitations in terms of the interventions that are used, the forms of violence that human rights practitioners respond to, and the types of survivors they seek to protect. Taken together, these four assumptions have created challenges for the human rights community in confronting the multiple forms of torture rooted in the deep and widespread inequality experienced by many poor and marginalized groups. The essay ends by pointing to some emerging themes in the fight against torture, such as a focus on inequality, extra-custodial violence, and the role of corruption.

scholarly journals Mechanism of porphobilinogen synthase. Possible role of essential thiol groups.

1977 ◽  
Vol 252 (24) ◽  
pp. 8965-8974 ◽  
Author(s):  
G.F. Barnard ◽  
R. Itoh ◽  
L.H. Hohberger ◽  
D. Shemin
Keyword(s):  
Thiol Groups ◽  
Porphobilinogen Synthase

On the molecular basis of pyruvate kinase deficiency II. Role of thiol groups in pyruvate kinase from pyruvate kinase-deficient patients

1974 ◽  
Vol 334 (2) ◽  
pp. 361-367 ◽  
Author(s):  
Th.J.C. Van Berkel ◽  
G.E.J. Staal ◽  
J.F. Koster ◽  
J.G. Nyessen ◽  
L. van Milligen-Boersma
Keyword(s):  
Pyruvate Kinase ◽  
Molecular Basis ◽  
Thiol Groups ◽  
Pyruvate Kinase Deficiency

scholarly journals The Role of Transcription Factor PU.I in the Activity of the Intronic Enhancer of the Eosinophil-Derived Neurotoxin (RNS2) Gene

Blood ◽  
1998 ◽  
Vol 91 (6) ◽  
pp. 2126-2132 ◽  
Author(s):  
Thamar B. van Dijk ◽  
Eric Caldenhoven ◽  
Jan A.M. Raaijmakers ◽  
Jan-Willem J. Lammers ◽  
Leo Koenderman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Point Mutations ◽  
Proximal Promoter ◽  
Multiple Forms ◽  
Enhancer Activity ◽  
Promoter Sequences ◽  
Intronic Enhancer ◽  
First Intron ◽  
Shift Analysis

Eosinophil-derived neurotoxin (EDN) found in the granules of human eosinophils is a cationic ribonuclease toxin. Expression of the EDN gene (RNS2) in eosinophils is dependent on proximal promoter sequences in combination with an enhancer located in the first intron. We further define here the active region of the intron using transfections in differentiated eosinophilic HL60 cells. We show that a region containing a tandem PU.I binding site is important for intronic enhancer activity. This region binds multiple forms of transcription factor PU.I as judged by gel-shift analysis and DNA affinity precipitation. Importantly, introducing point mutations in the PU.I site drastically reduces the intronic enhancer activity, showing the importance of PU.I for expression of EDN in cells of the eosinophilic lineage.

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