scholarly journals Formation of mercapturic acids in rats after the administration of aralkyl esters

1970 ◽  
Vol 118 (5) ◽  
pp. 765-771 ◽  
Author(s):  
J. J. Clapp ◽  
L. Young
Keyword(s):  
Subcutaneous Injection ◽  
Bile Ducts ◽  
Quantitative Method ◽  
Hippuric Acid ◽  
Benzyl Acetate ◽  
Mercapturic Acids ◽  
Naphthoic Acid ◽  
Chromatographic Evidence

1. Benzylmercapturic acid and hippuric acid were isolated from the urine of rats that had been injected subcutaneously with benzyl acetate. 2. 1-Menaphthylmercapturic acid and 1-naphthoic acid were isolated from the urine of rats after the subcutaneous injection of each of the following compounds: 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 3. A quantitative method for determining 1-menaphthylmercapturic acid in urine was developed and used to measure the excretion of this compound in the urine of rats in the 4-day period after the subcutaneous injection of 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 4. Chromatographic evidence was obtained for the presence of S-(1-menaphthyl)glutathione and S-(1-menaphthyl)-l-cysteine in bile collected from rats with cannulated bile ducts after the animals had been injected subcutaneously with each of the following compounds: S-(1-menaphthyl)glutathione, 1-menaphthyl acetate, propionate and butyrate. 5. Benzylmercapturic acid and 1-menaphthylmercapturic acid were isolated from the urine of rats that had been injected with sodium benzyl sulphate and sodium 1-menaphthyl sulphate respectively.

scholarly journals Biochemical studies of toxic agents. The metabolic formation of 1- and 2-menaphthylmercapturic acid

1968 ◽  
Vol 107 (4) ◽  
pp. 519-522 ◽  
Author(s):  
C. W. Hyde ◽  
L. Young
Keyword(s):  
Mercapturic Acids ◽  
Acid Excretion ◽  
Rat Urine ◽  
Alcohol Acetate ◽  
Toxic Agents ◽  
Biochemical Studies ◽  
Limited Series ◽  
Series Of Experiments ◽  
Derivatives Of ◽  
Chromatographic Evidence

1. Various derivatives of 1- and 2-methylnaphthalene, of the type C10H7·CH2X, were administered to rats and the urines of the dosed animals were examined for the presence of 1- and 2-menaphthylmercapturic acid by chromatographic and isolation procedures. A similar, but more limited, series of experiments was carried out with rabbits. 2. All the compounds were administered by subcutaneous injection with the exception of S-(1- and 2-menaphthyl)-l-cysteine, which were added to the food. 3. 1-Menaphthylmercapturic acid was isolated from the urine of rats after the administration of 1-menaphthyl chloride, bromide, alcohol, acetate and benzoate, S-(1-menaphthyl)-l-cysteine and S-(1-menaphthyl)glutathione. 4. 2-Menaphthylmercapturic acid was isolated from rat urine after administration of 2-menaphthyl chloride, S-(2-menaphthyl)-l-cysteine and S-(2-menaphthyl)-glutathione, and was detected chromatographically after injecting 2-menaphthyl bromide. 5. The corresponding mercapturic acids were isolated after administering 1- and 2-menaphthyl chloride and 1-menaphthyl acetate to rabbits, but not after giving 1- and 2-menaphthyl bromide and 1-menaphthyl alcohol, although chromatographic evidence of mercapturic acid excretion was obtained after injecting these compounds.

scholarly journals Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein

1973 ◽  
Vol 134 (4) ◽  
pp. 1093-1101 ◽  
Author(s):  
Clive M. Kaye
Keyword(s):  
Subcutaneous Injection ◽  
Allyl Alcohol ◽  
Mercapturic Acids ◽  
Allyl Acetate ◽  
Diallyl Phthalate ◽  
Allyl Esters

1. 3-Hydroxypropylmercapturic acid, i.e. N-acetyl-S-(3-hydroxypropyl)-l-cysteine, was isolated, as its dicyclohexylammonium salt, from the urine of rats after the subcutaneous injection of each of the following compounds: allyl alcohol, allyl formate, allyl propionate, allyl nitrate, acrolein and S-(3-hydroxypropyl)-l-cysteine. 2. Allylmercapturic acid, i.e. N-acetyl-S-allyl-l-cysteine, was isolated from the urine of rats after the subcutaneous injection of each of the following compounds: triallyl phosphate, sodium allyl sulphate and allyl nitrate. The sulphoxide of allylmercapturic acid was detected in the urine excreted by these rats. 3. 3-Hydroxypropylmercapturic acid was identified by g.l.c. as a metabolite of allyl acetate, allyl stearate, allyl benzoate, diallyl phthalate, allyl nitrite, triallyl phosphate and sodium allyl sulphate. 4. S-(3-Hydroxypropyl)-l-cysteine was detected in the bile of a rat dosed with allyl acetate.

A rapid quantitative method for the preparation of 123I-iodo-hippuric acid

1982 ◽  
Vol 7 (2) ◽  
Author(s):  
L. Hawkins ◽  
A. Elliott ◽  
R. Shields ◽  
K. Herman ◽  
P. Horton ◽  
...  
Keyword(s):  
Quantitative Method ◽  
Hippuric Acid

scholarly journals Biomarkers of toluene exposure in rats: mercapturic acids versus traditional indicators (urinary hippuric acid ando-cresol and blood toluene)

Xenobiotica ◽  
2013 ◽  
Vol 43 (8) ◽  
pp. 651-660 ◽  
Author(s):  
Frédéric Cosnier ◽  
Benoît Cossec ◽  
Manuella Burgart ◽  
Hervé Nunge ◽  
Céline Brochard ◽  
...  
Keyword(s):  
Hippuric Acid ◽  
Mercapturic Acids ◽  
Toluene Exposure ◽  
Blood Toluene

Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis

2003 ◽  
Vol 1 (4) ◽  
pp. 285-296 ◽  
Author(s):  
Junichi Shoda ◽  
Tetsuya Ueda ◽  
Toru Kawamoto ◽  
Takesi Todoroki ◽  
Toru Asano ◽  
...  
Keyword(s):  
Bile Ducts ◽  
Prostaglandin E
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