scholarly journals β-Alanyl-l-tyrosine. Chemical synthesis, properties and occurrence in larvae of the fleshfly Sarcophaga bullata Parker

1969 ◽  
Vol 113 (5) ◽  
pp. 837-841 ◽  
Author(s):  
L. Levenbook ◽  
R. P. Bodnaryk ◽  
T. F. Spande
Keyword(s):  
Chemical Synthesis ◽  
Physicochemical Properties ◽  
Larval Growth ◽  
Sarcophaga Bullata ◽  
Positive Material ◽  
Naturally Occurring ◽  
Synthesis Properties ◽  
Natural Peptide ◽  
Puparium Formation

1. A naturally occurring peptide, termed sarcophagine, has been isolated from larvae of the fleshfly Sarcophaga bullata. 2. The physicochemical properties of the natural peptide are identical with those of synthetic β-alanyl-l-tyrosine. 3. During larval growth the concentration of the dipeptide increases continuously; in the fully grown larva it is the predominant non-protein ninhydrin-positive material. 4. Sarcophagine is rapidly and extensively utilized at the time of hardening and darkening of the insect puparium. 5. By virtue of its much higher solubility than that of free tyrosine, the peptide may serve as a reservoir to provide large amounts of readily available tyrosine for subsequent puparium formation.

scholarly journals Postsynthetic On-Column 2′ Functionalization of RNA by Convenient Versatile Method

2020 ◽  
Vol 21 (14) ◽  
pp. 5127
Author(s):  
Olga A. Krasheninina ◽  
Veniamin S. Fishman ◽  
Alexander A. Lomzov ◽  
Alexey V. Ustinov ◽  
Alya G. Venyaminova
Keyword(s):  
Chemical Synthesis ◽  
Physicochemical Properties ◽  
Functional Groups ◽  
Convenient Method ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Protecting Groups ◽  
Hydroxyl Group ◽  
Phase Synthesis ◽  
Wide Range

We report a universal straightforward strategy for the chemical synthesis of modified oligoribonucleotides containing functional groups of different structures at the 2′ position of ribose. The on-column synthetic concept is based on the incorporation of two types of commercial nucleotide phosphoramidites containing orthogonal 2′-O-protecting groups, namely 2′-O-thiomorpholine-carbothioate (TC, as “permanent”) and 2′-O-tert-butyl(dimethyl)silyl (tBDMS, as “temporary”), to RNA during solid-phase synthesis. Subsequently, the support-bound RNA undergoes selective deprotection and follows postsynthetic 2′ functionalization of the naked hydroxyl group. This convenient method to tailor RNA, utilizing the advantages of solid phase approaches, gives an opportunity to introduce site-specifically a wide range of linkers and functional groups. By this strategy, a series of RNAs containing diverse 2′ functionalities were synthesized and studied with respect to their physicochemical properties.

scholarly journals Engineering polymerases for applications in synthetic biology

2020 ◽  
Vol 53 ◽  
Author(s):  
Ali Nikoomanzar ◽  
Nicholas Chim ◽  
Eric J. Yik ◽  
John C. Chaput
Keyword(s):  
Cell Division ◽  
Synthetic Biology ◽  
Substrate Specificity ◽  
Physicochemical Properties ◽  
Genetic Information ◽  
Biomedical Applications ◽  
Dna Polymerases ◽  
Enzyme Engineering ◽  
Practical Applications ◽  
Naturally Occurring

Abstract DNA polymerases play a central role in biology by transferring genetic information from one generation to the next during cell division. Harnessing the power of these enzymes in the laboratory has fueled an increase in biomedical applications that involve the synthesis, amplification, and sequencing of DNA. However, the high substrate specificity exhibited by most naturally occurring DNA polymerases often precludes their use in practical applications that require modified substrates. Moving beyond natural genetic polymers requires sophisticated enzyme-engineering technologies that can be used to direct the evolution of engineered polymerases that function with tailor-made activities. Such efforts are expected to uniquely drive emerging applications in synthetic biology by enabling the synthesis, replication, and evolution of synthetic genetic polymers with new physicochemical properties.

Carbon Quantum Dots: Chemical Synthesis, Properties and Applications

2015 ◽  
Vol 7 (4) ◽  
pp. 1306-1346 ◽  
Author(s):  
Cláudia Emanuele Machado ◽  
Kayo O. Vieira ◽  
Jefferson Luis Ferrari ◽  
Marco Antônio Schiavon
Keyword(s):  
Quantum Dots ◽  
Chemical Synthesis ◽  
Carbon Quantum Dots ◽  
Synthesis Properties

scholarly journals Structure and synthesis of naturally occurring anhydrovitamin A2

1979 ◽  
Vol 177 (3) ◽  
pp. 791-799 ◽  
Author(s):  
A B Barua ◽  
K Verma ◽  
S R Das
Keyword(s):  
Chemical Synthesis ◽  
Freshwater Fish ◽  
Mass Spectra ◽  
Chemical Conversion ◽  
Naturally Occurring

The structure of naturally occurring anhydrovitamin A2 was elucidated as 3-hydroxyanhydroretinol from study of its u.v.–visible, i.r., n.m.r. and mass spectra. The structure has been confirmed by a chemical synthesis. Saccobranchus fossils, a freshwater fish, can convert 3-hydroxyretinol into 3-hydroxyanhydroretinol, which in turn is converted into-3-dehydroretinol. Chemical conversion of 3-hydroxyretinol into 3-dehydroretinol was also carried out.

Biologically active acyclonucleoside analogues. II. The synthesis of 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62)

1982 ◽  
Vol 60 (24) ◽  
pp. 3005-3010 ◽  
Author(s):  
Kelvin K. Ogilvie ◽  
Ukken O. Cheriyan ◽  
Bruno K. Radatus ◽  
Kendall O. Smith ◽  
Karen S. Galloway ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Functional Groups ◽  
Biologically Active ◽  
Nucleoside Analogues ◽  
Naturally Occurring

The chemical synthesis of 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine is described. This compound, known as BIOLF-62, is active against herpesviruses. This compound is a member of a novel class of nucleoside analogues which lack a rigid carbohydrate ring, but which possess all of the functional groups of naturally occurring deoxynucleosides.

Synthesis, properties and uses of bacterial storage lipid granules as naturally occurring nanoparticles

Soft Matter ◽  
2010 ◽  
Vol 6 (17) ◽  
pp. 4045 ◽  
Author(s):  
Nicholas Thomson ◽  
David Summers ◽  
Easan Sivaniah
Keyword(s):  
Naturally Occurring ◽  
Storage Lipid ◽  
Synthesis Properties ◽  
Lipid Granules

scholarly journals The Removal Performance and Mechanisms of Tetracycline Over Mn-rich Limonite

2021 ◽  
Author(s):  
Luyao Wang ◽  
Hanlin Wang ◽  
Haibo Liu ◽  
Xuehua Zou ◽  
Dong Chen ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Physicochemical Properties ◽  
Active Sites ◽  
Manganese Oxides ◽  
Mesoporous Structure ◽  
High Specific Surface Area ◽  
Solution Ph ◽  
Natural Mineral ◽  
Naturally Occurring ◽  
Ft Ir

Abstract Naturally occurring Mn-rich limonite mainly composed of goethite and manganese oxides was used to remove tetracycline (TC) from the aqueous solution. The physicochemical properties of limonite were illustrated by various characterization techniques such as XRD, FE-TEM, XPS and FT-IR. The effects of dosage, initial solution pH, temperature and coexisting anions on TC removal were investigated. The results showed that TC could be efficiently adsorbed by limonite with high specific surface area and mesoporous structure through electrostatic interaction and complexation. The co-existence of PO43- inhibited the adsorption of TC by limonite due to the competition with TC for active sites. In addition, manganese oxides exhibited oxidative properties to TC, and the singlet oxygen (1O2) generated during the redox reaction was responsible for TC degradation. Furthermore, the regenerated limonite displayed an efficient recycling performance after four cycles. This study revealed that the Mn-rich limonite was a promising adsorbent for TC removal from aqueous solutions and promoted the application of natural mineral material in the environmental field.

Advances in synthesis, properties and emerging applications of tin sulfides and its heterostructures

2021 ◽  
Author(s):  
Pratik Shinde ◽  
Chandra Sekhar Rout
Keyword(s):  
Physicochemical Properties ◽  
Recent Progress ◽  
Research Interest ◽  
Tin Sulfide ◽  
Synthesis Properties ◽  
Tin Sulfides

The tin sulfide (SnxSy) class of materials has attracted tremendous research interest owing to their intriguing physicochemical properties. In this review, we explore the recent progress in their synthesis, properties, and applications.

scholarly journals Nonenzymatic synthesis of anomerically pure, mannosyl-based molecular probes for scramblase identification studies

2020 ◽  
Vol 16 ◽  
pp. 1732-1739
Author(s):  
Giovanni Picca ◽  
Markus Probst ◽  
Simon M Langenegger ◽  
Oleg Khorev ◽  
Peter Bütikofer ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Chemical Synthesis ◽  
Molecular Probes ◽  
Protein Glycosylation ◽  
Pure Form ◽  
Short Chain ◽  
Biological Pathway ◽  
Naturally Occurring ◽  
Phosphoramidite Chemistry ◽  
Straightforward Approach

The chemical synthesis of molecular probes to identify and study membrane proteins involved in the biological pathway of protein glycosylation is described. Two short-chain glycolipid analogs that mimic the naturally occurring substrate mannosyl phosphoryl dolichol exhibit either photoreactive and clickable properties or allow the use of a fluorescence readout. Both probes consist of a hydrophilic mannose headgroup that is linked to a citronellol derivative via a phosphodiester bridge. Moreover, a novel phosphoramidite chemistry-based method offers a straightforward approach for the non-enzymatic incorporation of the saccharide moiety in an anomerically pure form.

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