scholarly journals The dimerization of Δ1-piperidine-2-carboxylic acid

1967 ◽  
Vol 105 (2) ◽  
pp. 663-667 ◽  
Author(s):  
D B Hope ◽  
K. C. Horncastle ◽  
R. T. Aplin
Keyword(s):  
Molecular Weight ◽  
Nuclear Magnetic Resonance ◽  
Schiff Base ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Magnetic Resonance ◽  
Mass Spectra ◽  
Large Scale ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

The l-amino acid oxidase of Mytilus edulis has been used to oxidize l-lysine on a large scale in the presence of catalase. The α-oxo acid derived from lysine cyclizes to a Schiff base, which readily dimerizes. The dimer undergoes spontaneous dehydration and decarboxylation to form 1,2,3,4,5,6,7,8-octahydropyrido[3,2-a]-indolizin-10(4bH)-one. This structure was established by a study of its molecular weight and infrared, nuclear-magnetic-resonance and mass spectra.

scholarly journals The mechanism of action of serine transhydroxymethylase

1970 ◽  
Vol 116 (2) ◽  
pp. 277-286 ◽  
Author(s):  
P. M. Jordan ◽  
M. Akhtar
Keyword(s):  
Schiff Base ◽  
Amino Acid ◽  
Hydrogen Atom ◽  
Mechanism Of Action ◽  
Active Site ◽  
Enzyme Preparation ◽  
Pyridoxal Phosphate ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

1. The preparation of stereospecifically tritiated glycines and the determination of their absolute configurations by the use of d-amino acid oxidase are described. 2. The reaction catalysed by serine transhydroxymethylase, which results in the conversion of glycine into serine, has been separated into at least four partial reactions. It is suggested that the first event in this conversion is the formation of a Schiff base intermediate of glycine and pyridoxal phosphate. The next important step involves the removal of the 2S-hydrogen atom of glycine to give a carbanion intermediate. Experiments pertinent to the mechanism of conversion of this carbanion intermediate into serine are described. 3. The enzyme preparation catalysing the conversion of glycine into serine also participates in the conversion of glycine into threonine and allothreonine. In both these conversions, glycine → serine and glycine → threonine, the 2S-hydrogen atom of glycine is eliminated and the 2R-hydrogen atom of glycine is retained. 4. In the light of these experiments the mechanism of action of serine transhydroxymethylase is discussed. It is suggested that methylenetetrahydrofolate is the carrier of formaldehyde, from which formaldehyde may be liberated at the active site of the enzyme, thus allowing the overall reaction to take place.

Molecular weight and configuration of d-amino acid oxidase protein

1961 ◽  
Vol 54 (1) ◽  
pp. 199-201 ◽  
Author(s):  
Kunio Yagi ◽  
Takayuki Ozawa ◽  
Tatsuo Ooi
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

Isomers of bis(trifluoromethyl)phosphinomethylhydrazine, (CF3)2PNHNHMe and (CF3)2PN(Me)NH2

1969 ◽  
Vol 47 (22) ◽  
pp. 4281-4283 ◽  
Author(s):  
L. K. Peterson ◽  
G. L. Wilson
Keyword(s):  
Molecular Weight ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Vapor Phase ◽  
Mass Spectra ◽  
Electronic Effects ◽  
Nuclear Magnetic

The synthesis of isomers of bis(trifluoromethyl)phosphinomethylhydrazine, (CF3)2PNHNHMe, 1, and (CF3)2PN(Me)NH2, 2, and their characterization by infrared, nuclear magnetic resonance, and mass spectra, and by vapor phase molecular weight measurements are described. The significance of the formation of both isomers is discussed in terms of steric and electronic effects.

Isolation and characterization of a fungistatic principle produced by bacteria

1968 ◽  
Vol 14 (12) ◽  
pp. 1289-1296 ◽  
Author(s):  
P. L. Smith ◽  
R. J. Green Jr.
Keyword(s):  
Molecular Weight ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Potential Role ◽  
Pseudomonas Sp ◽  
Isolation And Characterization ◽  
Soil Fungistasis

A fungistatic principle produced by a bacterium Pseudomonas sp. was isolated, characterized, and its potential role in soil fungistasis considered. The principle was isolated from a concentrated cultural filtrate of the bacterium by the use of column chromatography, and characterized by its solubility and elemental analysis and by infrared, nuclear magnetic resonance, and mass spectra. The fungistatic principle was an unsaturated, aliphatic, hydroxyketone with a molecular weight of approximately 166. This compound could be recovered from soil only with organic solvents and, therefore, it was concluded that the principle probably does not contribute to soil fungistasis.

Improved purification, amino acid analysis and molecular weight of homogeneous d-amino acid oxidase from pig kidney

1973 ◽  
Vol 327 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Bruno Curti ◽  
Severino Ronchi ◽  
Umberto Branzoli ◽  
Giuseppina Ferri ◽  
Charles H. Williams
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Amino Acid Analysis ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Pig Kidney
Sign in / Sign up

Export Citation Format

Share Document