scholarly journals Effects of fatty acids, ketone bodies, lactate and pyruvate on glucose utilization by guinea-pig cerebral cortex slices

1967 ◽  
Vol 104 (2) ◽  
pp. 519-523 ◽  
Author(s):  
FS Rolleston ◽  
EA Newsholme
Keyword(s):  
Fatty Acids ◽  
Cerebral Cortex ◽  
Guinea Pig ◽  
Glucose Utilization ◽  
Ketone Bodies ◽  
Lactate And Pyruvate ◽  
Cortex Slices

Effect of (-)nicotine on GABA efflux from guinea pig cerebral cortex slices

1989 ◽  
Vol 21 ◽  
pp. 133-134 ◽  
Author(s):  
P. Spalluto ◽  
M. Morari ◽  
L. Ferraro ◽  
A. Nordberg ◽  
T. Antonelli ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Guinea Pig ◽  
Cortex Slices

Changes in Oxidative Metabolism of Guinea Pig Brain Cortex Slices in the Presence of Meso-Inositol Hexanicotinate and Nicotinic Acid

1973 ◽  
Vol 1 (3) ◽  
pp. 192-193 ◽  
Author(s):  
P Joanny ◽  
P Balansard ◽  
J Legros
Keyword(s):  
Cerebral Cortex ◽  
Oxygen Uptake ◽  
Guinea Pig ◽  
Protective Effect ◽  
Nicotinic Acid ◽  
Brain Cortex ◽  
Brain Cortex Slices ◽  
Cortex Slices ◽  
Guinea Pig Brain

Both nicotinic acid and meso-inositol hexanicotinate significantly decrease oxygen uptake of isolated guinea-pig cerebral cortex. This inhibition is tentatively correlated to the already described protective effect against hypoxia produced by these compounds in vivo.

scholarly journals Development of fatty acid oxidation in neonatal guinea-pig liver

1982 ◽  
Vol 208 (3) ◽  
pp. 723-730 ◽  
Author(s):  
D A Shipp ◽  
M Parameswaran ◽  
I J Arinze
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Guinea Pig ◽  
Ketone Bodies ◽  
Liver Mitochondria ◽  
Fatty Acyl ◽  
Acid Oxidation ◽  
Beta Oxidation ◽  
Pig Liver ◽  
Guinea Pig Liver

The capacity of foetal and neonatal liver to oxidize short-, medium- and long-chain fatty acids was studied in the guinea pig. Liver mitochondria from foetal and newborn animals were unable to synthesize ketone bodies from octanoate, but octanoylcarnitine and palmitoylcarnitine were readily ketogenic. The ketogenic capacity at 24 h after birth was as high as in adult animals. Hepatocytes isolated from term animals were unable to oxidize fatty acids, but at 6 h after birth production of 14CO2, acid-soluble products and acetoacetate from 1-14C-labelled fatty acids was 40-50% of the rates at 24 h. At 12 h of age these rates had already reached the 24 h values and did not change during suckling in the first week of life. The activities of hepatic fatty acyl-CoA synthetases, which were minimal in the foetus or at term, increased to maximal values in 12-24 h. The data show that the capacity for beta-oxidation and ketogenesis develops maximally in this species during the first 6-12 h after birth, and appears to be partly dependent on the development of fatty acid-activating enzyme.

scholarly journals Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine

1972 ◽  
Vol 126 (3) ◽  
pp. 575-585 ◽  
Author(s):  
C. J. Price ◽  
C. E. Rowe
Keyword(s):  
Fatty Acids ◽  
Cerebral Cortex ◽  
Guinea Pig ◽  
Synaptic Vesicles ◽  
Nerve Endings ◽  
Synaptic Membranes ◽  
Pig Brain ◽  
Guinea Pig Brain ◽  
Stimulation Of

1. Noradrenaline (1mm) and 5-hydroxytryptamine (1mm) stimulated the production of unesterified palmitate, oleate, stearate and arachidonate in nerve endings (synaptosomes) isolated from combined guinea-pig cerebral cortex and cerebellum. 2. Iproniazid phosphate (0.36mm) increased the concentrations of the same acids in osmotically ruptured synaptosomes. Further addition of 1mm-noradrenaline or 1mm-5-hydroxytryptamine reversed this increase. 3. Noradrenaline (0.01mm) stimulated the production of unesterified fatty acids in isolated synaptic membranes. 5-Hydroxytryptamine (0.01mm) stimulated the production of unesterified fatty acids in synaptic membranes and synaptic vesicles.

Effect of γ-aminobutyric acid on cyclic nucleotides content of guinea-pig cerebral cortex slices

1984 ◽  
Vol 16 (9) ◽  
pp. 933-943
Author(s):  
T. Antonelli ◽  
F. Caciagli ◽  
L. Lambertini ◽  
E. Veratti ◽  
C. Bianchi
Keyword(s):  
Cerebral Cortex ◽  
Guinea Pig ◽  
Cyclic Nucleotides ◽  
Aminobutyric Acid ◽  
Cortex Slices
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