scholarly journals Adenosine triphosphate-nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei. Extraction and purification of the enzyme

1964 ◽  
Vol 90 (2) ◽  
pp. 433-438 ◽  
Author(s):  
MR Atkinson ◽  
JF Jackson ◽  
RK Morton
Keyword(s):  
Adenosine Triphosphate ◽  
Pig Liver ◽  
Nicotinamide Mononucleotide ◽  
Extraction And Purification ◽  
Liver Nuclei ◽  
Nicotinamide Mononucleotide Adenylyltransferase

Nicotinamide mononucleotide adenylyltransferase. Molecular and enzymic properties of the homogeneous enzyme from bakers' yeast

Biochemistry ◽  
1986 ◽  
Vol 25 (12) ◽  
pp. 3725-3729 ◽  
Author(s):  
Paolo Natalini ◽  
Silverio Ruggieri ◽  
Nadia Raffaelli ◽  
Giulio Magni
Keyword(s):  
Nicotinamide Mononucleotide ◽  
Nicotinamide Mononucleotide Adenylyltransferase

scholarly journals Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi

2015 ◽  
Vol 110 (7) ◽  
pp. 890-897 ◽  
Author(s):  
Carlos H Niño ◽  
Nicolás Forero-Baena ◽  
Luis E Contreras ◽  
Diana Sánchez-Lancheros ◽  
Katherine Figarella ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Nicotinamide Mononucleotide ◽  
Nicotinamide Mononucleotide Adenylyltransferase

Structure and Function of Nicotinamide Mononucleotide Adenylyltransferase

2004 ◽  
Vol 11 (7) ◽  
pp. 873-885 ◽  
Author(s):  
G. Magni ◽  
A. Amici ◽  
M. Emanuelli ◽  
G. Orsomando ◽  
N. Raffaelli ◽  
...  
Keyword(s):  
Structure And Function ◽  
Nicotinamide Mononucleotide ◽  
Nicotinamide Mononucleotide Adenylyltransferase ◽  
And Function

scholarly journals The NAD+ Synthesis Enzyme Nicotinamide Mononucleotide Adenylyltransferase (NMNAT1) Regulates Ribosomal RNA Transcription

2013 ◽  
Vol 288 (29) ◽  
pp. 20908-20917 ◽  
Author(s):  
Tanjing Song ◽  
Leixiang Yang ◽  
Neha Kabra ◽  
Lihong Chen ◽  
John Koomen ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Lung Tumor ◽  
Human Cancer ◽  
Rrna Synthesis ◽  
Rrna Transcription ◽  
Nicotinamide Mononucleotide ◽  
Nad Synthesis ◽  
Increased Sensitivity ◽  
Nicotinamide Mononucleotide Adenylyltransferase

The chromosomal region encoding the nuclear NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) is frequently deleted in human cancer. We describe evidence that NMNAT1 interacts with the nucleolar repressor protein nucleomethylin and is involved in regulating rRNA transcription. NMNAT1 binds to nucleomethylin and is recruited into a ternary complex containing the NAD+-dependent deacetylase SirT1. NMNAT1 expression stimulates the deacetylase function of SirT1. Knockdown of NMNAT1 enhances rRNA transcription and promotes cell death after nutrient deprivation. Furthermore, NMNAT1 expression is induced by DNA damage and plays a role in preventing cell death after damage. Heterozygous deletion of NMNAT1 in lung tumor cell lines correlates with low expression level and increased sensitivity to DNA damage. These results suggest that NMNAT1 deletion in tumors may contribute to transformation by increasing rRNA synthesis, but may also increase sensitivity to nutrient stress and DNA damage.

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