The Rate of Turnover of Messenger Ribonucleic Acid in Rat Diaphragm Muscle

1964 ◽  
Vol 90 (2) ◽  
pp. 5C-7C ◽  
Author(s):  
K. L. Manchester
Keyword(s):  
Ribonucleic Acid ◽  
Diaphragm Muscle ◽  
Rat Diaphragm ◽  
Messenger Ribonucleic Acid

scholarly journals Effect of denervation on the synthesis of ribonucleic acid and deoxyribonucleic acid in rat diaphragm muscle

1968 ◽  
Vol 108 (2) ◽  
pp. 177-183 ◽  
Author(s):  
K L Manchester ◽  
E J Harris
Keyword(s):  
Nucleic Acids ◽  
Ribonucleic Acid ◽  
Orotic Acid ◽  
Deoxyribonucleic Acid ◽  
Diaphragm Muscle ◽  
Unit Mass ◽  
Rat Diaphragm ◽  
The Third

1. The effect of unilateral denervation of rat diaphragm muscle on its content of nucleic acids and their incorporation of precursors was investigated. 2. After denervation the paralysed hemidiaphragm hypertrophies and within 3 days its content of RNA increases considerably. The concentration of DNA/unit mass remains fairly constant. 3. During this period there is some increase in the rate of incorporation of [14C]adenine into RNA, whereas there is some diminution in the rate of incorporation of [14C]orotic acid. 4. Incorporation of [14C]adenine and [3H]thymidine into DNA is much increased in the paralysed tissue, reaching its maximum by about the third day, but returning to normal by the tenth. 5. The significance of these results in relation to the hypertrophy after denervation is discussed.

scholarly journals Quantitative Measurement of Ovalbumin Messenger Ribonucleic Acid Activity

1973 ◽  
Vol 248 (6) ◽  
pp. 2031-2039 ◽  
Author(s):  
Robert E. Rhoads ◽  
G. Stanley McKnight ◽  
Robert T. Schimke
Keyword(s):  
Ribonucleic Acid ◽  
Quantitative Measurement ◽  
Messenger Ribonucleic Acid

scholarly journals Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines?

Pain Medicine ◽  
2021 ◽  
Vol 22 (4) ◽  
pp. 994-1000
Author(s):  
Haewon Lee ◽  
Jennifer A Punt ◽  
David C Miller ◽  
Ameet Nagpal ◽  
Clark C Smith ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Ribonucleic Acid ◽  
Direct Evidence ◽  
Corticosteroid Injection ◽  
Vaccine Dose ◽  
Hypothalamic Pituitary Adrenal ◽  
Messenger Ribonucleic Acid ◽  
Corticosteroid Injections

Abstract Myth Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19). Fact There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine. However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible.

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