scholarly journals The incorporation of [2-14C] glycine and [6-14C] orotic acid into the acid-soluble ribonucleotides and ribonucleic acids of the rat mammary gland

1962 ◽  
Vol 83 (3) ◽  
pp. 626-632 ◽  
Author(s):  
DY WANG ◽  
AL GREENBAUM
Keyword(s):  
Mammary Gland ◽  
Orotic Acid ◽  
Ribonucleic Acids ◽  
Rat Mammary Gland

scholarly journals Almost Exclusive Androgenic Action of Dehydroepiandrosterone in the Rat Mammary Gland

Endocrinology ◽  
1998 ◽  
Vol 139 (2) ◽  
pp. 753-764 ◽  
Author(s):  
Antigone Sourla ◽  
Céline Martel ◽  
Claude Labrie ◽  
Fernand Labrie
Keyword(s):  
Mammary Gland ◽  
Rat Mammary Gland

scholarly journals Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Lina Ding ◽  
Yang Zhao ◽  
Christopher L Warren ◽  
Ruth Sullivan ◽  
Kevin W Eliceiri ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Cancer ◽  
Molecular Responses ◽  
17Β Estradiol ◽  
Rat Mammary Gland

scholarly journals Phosphoribosyl pyrophosphate and phosphoribosyl pyrophosphate synthetase in rat mammary gland. Changes in the lactation cycle and effects of diabetes, insulin and phenazine methosulphate

1986 ◽  
Vol 238 (2) ◽  
pp. 553-559 ◽  
Author(s):  
S Kunjara ◽  
M Sochor ◽  
N Salih ◽  
P McLean ◽  
A L Greenbaum
Keyword(s):  
Mammary Gland ◽  
Fold Increase ◽  
Pentose Phosphate ◽  
Diabetic Rat ◽  
Synthetase Activity ◽  
Phosphoribosyl Pyrophosphate ◽  
Rat Mammary Gland ◽  
Lactation Cycle ◽  
Phenazine Methosulphate

Changes in the tissue content of phosphoribosyl pyrophosphate (PPRibP), glucose 6-phosphate, ribose 5-phosphate (Rib5P), RNA and DNA, of the activity of PPRibP synthetase (EC 2.7.6.1) and the conversion of [1-14C]- and [6-14C]-glucose into 14CO2 were measured at mid-lactation in the normal and diabetic rat and in pregnancy, lactation and mammary involution in the normal rat. The PPRibP, glucose 6-phosphate and Rib5P contents increase during pregnancy and early lactation to reach a plateau value at mid-lactation, before falling sharply during weaning. The PPRibP content, PPRibP synthetase activity and flux of glucose through the oxidative pentose phosphate pathway (PPP) all change in parallel during the lactation cycle. Similarly, after 3 and 5 days duration of streptozotocin-induced diabetes, ending on day 10 of lactation, there were parallel declines in PPRibP content, PPRibP synthetase and PPP activity. The effect of streptozotocin was prevented by pretreatment with nicotinamide and partially reversed by insulin administration. Addition of insulin to lactating rat mammary-gland slices incubated in vitro significantly raised the PPRibP content (+47%) and the activity of the PPP (+40%); phenazine methosulphate, which gives a 2-fold increase in PPP activity, raised the PPRibP content of lactating mammary gland slices by approx. 3-fold. It is concluded that Rib5P, generated in the oxidative segment of the PPP, is an important determinant of PPRibP synthesis in the lactating rat mammary gland and that insulin plays a central role in the regulation of the bioavailability of this precursor of nucleotide and nucleic acid synthesis.

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