scholarly journals Physicochemical properties of hyaluronic acid formed by Streptococcus haemolyticus

1958 ◽  
Vol 70 (1) ◽  
pp. 1-4 ◽  
Author(s):  
B. S. Blumberg ◽  
A. G. Ogston ◽  
D. A. Lowther ◽  
H. J. Rogers
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties

scholarly journals Physicochemical Properties of Injectable Hyaluronic Acid: Skin Quality Boosters

2021 ◽  
pp. 2100134
Author(s):  
Linda Kleine‐Börger ◽  
Alexander Kalies ◽  
Robert SA Meyer ◽  
Martina Kerscher
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Skin Quality

scholarly journals Osteoconstructive nanocomposite based on polyurethane with additives of polysaccharides of various origin

2020 ◽  
Vol 61 (2) ◽  
pp. 68-78
Author(s):  
Nadezhda M. Storozhok ◽  
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Sodium Alginate ◽  
Cellular Structure ◽  
Xanthan Gum ◽  
The Body ◽  
Polygalacturonic Acid ◽  
Adhesive Properties ◽  
The Impact ◽  
Bone Glue

The basics of chemistry and manufacturing techniques of medical bone glue based on a polymer-polyurethane matrix, in which natural polysaccharides are additionally introduced, are described. The physicomechanical characteristics of the reconstructed bones (on the model of pork ribs) are given in comparison with polyurethane without additives (kryptonite). We measured the force necessary for a longitudinal fracture of the bone at the junction, the impact force leading to the destruction of the polymer. The tests were carried out on a universal machine for tensile testing IR 5047-50, the tensile strength of which reaches 50×103 N. It is shown that, compared with the mechanical strength of kryptonite (0.85 kPa), most polysaccharide composites are stronger from 1.2 to 2,3 times. Additives of sodium alginate and hyaluronic acid contribute to the formation of the most stable structures (2.00 MPa and 1.60 MPa, respectively). The strength of the glue with the inclusion of chitin is 1.05 MPa. The least tear resistant is the polyurethane-pectin copolymer (0.140 MPa). The low strength of glue with pectin is explained by the features of its chemical structure, a high degree of esterification of polygalacturonic acid (84%). Impact destruction of the material was recorded at 200 MPa, while the composite crack did not break up into fragments. Thus, the strength of new biopolymer composites is determined by the structure of polysaccharides, which increase the adhesive properties of potential medical adhesives. Using a JSM-6510 LA scanning electron microscope from JEOL (Japan), it was shown that the composite is a cellular structure along the entire depth of the material, 70% of the polymer has pores with a size (55-160) microns. The resulting glue may be compatible with bone tissue. Osteoblasts with a size of 20-30 μm can grow into the cellular structure of new materials and further increase their strength by osseointegration with the host bone. It was found that complete curing of kryptonite occurs in 75 minutes. Materials with additives of other polysaccharides can be cured in much less time (hyaluronic acid, xanthan, pectin in 15 minutes, sodium alginate in 50 minutes. The exception was chitin, which hardens in 200 minutes. During curing, the volume of all polymers increased and amounted to pectin, hyaluronic acid, xanthan gum, sodium alginate, chitin (32; 50; 62; 110, 250)% of the initial value, respectively. Kryptonite was characterized by a 130% increase in volume. Studying the interaction of polymers with water in an isotonic solution of sodium chlorine, imitating the internal environment of the body, showed that kryptonite does not absorb water within 40 days of observation, the mass of pectin increased by 2% in 2 days, xanthan – by 5%, sodium alginate – by 12%, and in 40 days the mass of xanthan gum and sodium alginate increased by 12 and 24%, respectively. The polyurethane composite with pectin lost 10% of its mass in the first 2 days and 35% in the next 40 days, which indicates hydrolysis of ester bonds in polygalacturonic acid. A composite with hyaluronic acid quickly absorbed water (30% in the first 6 hours), turned into a gel and lost its adhesive properties. In air, this polymer hardens quite quickly. It is obvious that composites with hyaluronic acid can only be used in an anhydrous environment. The most promising as medical bone glue is a polyurethane-xanthan copolymer, the physicochemical properties of which (curing time 15 minutes, an increase in volume by 62%) allow the formation of a bone bonding area and also regulate its surface during surgery. There is a direct relationship between the physicochemical properties of the new composites, the features of the primary structure, and the spatial organization of carbohydrate macromolecules. A methodological approach to the development of adhesives promising for reconstructive medicine of mineralized tissues is proposed.

scholarly journals Polysaccharides in Ocular Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 22 ◽  
Author(s):  
Natallia Dubashynskaya ◽  
Daria Poshina ◽  
Sergei Raik ◽  
Arto Urtti ◽  
Yury A. Skorik
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Alginic Acid ◽  
Drug Carriers ◽  
Ocular Drug Delivery ◽  
Pharmacological Effects ◽  
Drug Formulations ◽  
Ophthalmic Drugs ◽  
Polysaccharide Derivatives

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

scholarly journals Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

2019 ◽  
Vol 8 (6) ◽  
pp. 2 ◽  
Author(s):  
Pasquale Aragona ◽  
Peter A. Simmons ◽  
Hongpeng Wang ◽  
Tao Wang
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Eye Drops

Hyaluronic acid lipoate: Synthesis and physicochemical properties

2013 ◽  
Vol 93 (1) ◽  
pp. 273-278 ◽  
Author(s):  
Fabrizio Picotti ◽  
Matteo Fabbian ◽  
Rita Gianni ◽  
Alessandra Sechi ◽  
Luca Stucchi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties

Evaluation of Physicochemical Properties Following Syringe-to-Syringe Mixing of Hyaluronic Acid Dermal Fillers

2020 ◽  
Vol 46 (12) ◽  
pp. 1606-1612 ◽  
Author(s):  
Mitchel P. Goldman ◽  
Julius Few ◽  
Sandra Binauld ◽  
Illyce Nuñez ◽  
Christopher K. Hee ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Dermal Fillers
Sign in / Sign up

Export Citation Format

Share Document