scholarly journals Studies on the determination of the sequence of amino acids in peptides and proteins. 3. The synthesis of 3-(4′-dimethylamino-3′:5′-dinitrophenyl)hydantoin derivatives of various amino acids, and their use for the determination of N-terminal amino acids

1954 ◽  
Vol 56 (1) ◽  
pp. 111-116 ◽  
Author(s):  
G. G. Evans ◽  
W. S. Reith
1977 ◽  
Vol 55 (5) ◽  
pp. 521-527 ◽  
Author(s):  
Tateo Suzuki ◽  
Tetsuhisa Tomioka ◽  
Katura Tuzimura

Proton magnetic resonance spectra of methylthiohydantoin (3-methyl-2-thiohydantoin), thiohydantoin (2-thiohydantoin), and hydantoin derivatives of amino acids were studied in dimethyl sulfoxide-d6. Their parent amino acids could be identified by the spectra. An application to the N- and C-terminal amino acid analysis of a tripeptide was examined.


1957 ◽  
Vol 11 ◽  
pp. 194-195 ◽  
Author(s):  
Birger Blombäck ◽  
Ikuo Yamashina ◽  
S. Ross ◽  
J. Schliack ◽  
L. Reio
Keyword(s):  

1976 ◽  
Vol 153 (1) ◽  
pp. 137-138 ◽  
Author(s):  
K W Bentley

Quantitative N-terminal peptide-bond hydrolysis with the cis-beta-hydroxyaquo(triethylenetetramine) cobal (III) ion, i.e. β-[Co(trien)(OH)(OH2)]2+, is reported. The method has been demonstrated with 20 small peptides, a hexapeptide, bradykinin, insulin A chain (oxidized), glucagon and insulin. The procedure involves no acidic hydrolysis step and thus no destruction of labile amino acids.


1969 ◽  
Vol 7 (3) ◽  
pp. 328-333 ◽  
Author(s):  
A. Signor ◽  
L. Biondi ◽  
A. M. Tamburro ◽  
E. Bordignon
Keyword(s):  

1975 ◽  
Vol 53 (9) ◽  
pp. 1005-1009 ◽  
Author(s):  
C. S. Tsai ◽  
N. L. Fraser ◽  
H. Avdovich ◽  
J. P. Farant

Proton magnetic spectra of 3-phenyl-2-thiohydantoin derivatives of common amino acids in deuterated dimethyl sulfoxide were recorded. Spectral data pertaining to characteristic protons for diagnostic purpose were compiled. Their application to the N-terminal amino acid analysis of peptide by Edman degradation was examined.


Nature ◽  
1956 ◽  
Vol 178 (4539) ◽  
pp. 912-913 ◽  
Author(s):  
J. H. BRADBURY
Keyword(s):  

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