scholarly journals The virulence-enhancing factor of mucins. 1. A biological assay of virulence-enhancing activity

1950 ◽  
Vol 46 (3) ◽  
pp. 352-356 ◽  
Author(s):  
H. Smith
Keyword(s):  
Biological Assay ◽  
Enhancing Factor

scholarly journals Use of Radioactive Materials in Biological Assay

Nature ◽  
1955 ◽  
Vol 176 (4479) ◽  
pp. 427-430 ◽  
Author(s):  
R. F. GLASCOCK
Keyword(s):  
Biological Assay ◽  
Radioactive Materials

scholarly journals A METHOD FOR THE BIOLOGICAL ASSAY OF COD LIVER OIL

1928 ◽  
Vol 78 (2) ◽  
pp. 495-524
Author(s):  
Georgian Adams ◽  
E.V. McCollum
Keyword(s):  
Biological Assay ◽  
Cod Liver Oil

Cloning and sequencing of the gene for an enhancing factor from Pseudaletia separata entomopoxvirus

Gene ◽  
1996 ◽  
Vol 177 (1-2) ◽  
pp. 269-270 ◽  
Author(s):  
Takahiko Hayakawa ◽  
Jinhua Xu ◽  
Toshihiko Hukuhara
Keyword(s):  
Cloning And Sequencing ◽  
Enhancing Factor ◽  
Pseudaletia Separata

A QSAR Model for in Silico Screening of MAO-A Inhibitors. Prediction, Synthesis, and Biological Assay of Novel Coumarins†

2006 ◽  
Vol 49 (3) ◽  
pp. 1149-1156 ◽  
Author(s):  
Lourdes Santana ◽  
Eugenio Uriarte ◽  
Humberto González-Díaz ◽  
Giuseppe Zagotto ◽  
Ramón Soto-Otero ◽  
...  
Keyword(s):  
In Silico ◽  
Qsar Model ◽  
Biological Assay ◽  
In Silico Screening ◽  
Mao A

Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay

2011 ◽  
Vol 37 (9) ◽  
pp. 1212-1215 ◽  
Author(s):  
Marisa Pascale Quintino ◽  
Mary Uchiyama Nakamura ◽  
Manuel de Jesus Simões ◽  
Edward Araujo Júnior ◽  
Ricardo Martins de Oliveira Filho ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Biological Assay ◽  
Albino Rat ◽  
Chronic Use

Diffusible amyloid oligomers trigger systemic amyloidosis in mice

2008 ◽  
Vol 415 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Sivanesan Senthilkumar ◽  
Edwin Chang ◽  
Rajadas Jayakumar
Keyword(s):  
Protein A ◽  
Mouse Tissue ◽  
Cytokine Induction ◽  
Amyloidogenic Proteins ◽  
Enhancing Factor ◽  
Amyloid Oligomers ◽  
Apparent Relationship ◽  
Amyloid Enhancing Factor ◽  
Local Accumulation

AA (amyloid protein A) amyloidosis in mice is markedly accelerated when the animals are given, in addition to an inflammatory stimulus, an intravenous injection of protein extracted from AA-laden mouse tissue. Previous findings affirm that AA fibrils can enhance the in vivo amyloidogenic process by a nucleation seeding mechanism. Accumulating evidence suggests that globular aggregates rather than fibrils are the toxic entities responsible for cell death. In the present study we report on structural and morphological features of AEF (amyloid-enhancing factor), a compound extracted and partially purified from amyloid-laden spleen. Surprisingly, the chief amyloidogenic material identified in the active AEF was diffusible globular oligomers. This partially purified active extract triggered amyloid deposition in vital organs when injected intravenously into mice. This implies that such a phenomenon could have been inflicted through the nucleation seeding potential of toxic oligomers in association with altered cytokine induction. In the present study we report an apparent relationship between altered cytokine expression and AA accumulation in systemically inflamed tissues. The prevalence of serum AA monomers and proteolytic oligomers in spleen AEF is consistent to suggest that extrahepatic serum AA processing might lead to local accumulation of amyloidogenic proteins at the serum AA production site.

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