Structure determination of reaction products of pyrroloquinolinequinone (PQQ) with L-tryptophan in vitro and their effects for microbacterial growth

1996 ◽  
pp. 1331 ◽  
Author(s):  
Eiji Kawamoto ◽  
Takashi Amano ◽  
Jyutoku Kanayama ◽  
Yasuko In ◽  
Mitsunobu Doi ◽  
...  
Keyword(s):  
Structure Determination ◽  
Reaction Products

Diorganotin difluorobenzoates: synthesis, spectroscopic characterization and in vitro antitumour activity. X-Ray structure determination of bis[di-n-butyl(2,6-difluorobenzoato)tin] oxide

1993 ◽  
Vol 64 (3) ◽  
pp. 279-291 ◽  
Author(s):  
Marcel Gielen ◽  
Monique Biesemans ◽  
Abdelaziz El Khloufi ◽  
Jacqueline Meunier-Piret ◽  
François Kayser ◽  
...  
Keyword(s):  
Tin Oxide ◽  
Structure Determination ◽  
Antitumour Activity ◽  
Spectroscopic Characterization ◽  
X Ray

Synthesis and structure determination of 6-methylbenzo[a]pyrene-deoxyribonucleoside adducts and their identification and quantitation in vitro and in mouse skin

2000 ◽  
Vol 128 (1) ◽  
pp. 65-90 ◽  
Author(s):  
Aaron A Hanson ◽  
Kai-Ming Li ◽  
Cheng-Huang Lin ◽  
Ryszard Jankowiak ◽  
Gerald J Small ◽  
...  
Keyword(s):  
Structure Determination ◽  
Mouse Skin

Structure Determination of Formic Acid Reaction Products on TiO2(110)†

2004 ◽  
Vol 108 (38) ◽  
pp. 14316-14323 ◽  
Author(s):  
D. I. Sayago ◽  
M. Polcik ◽  
R. Lindsay ◽  
R. L. Toomes ◽  
J. T. Hoeft ◽  
...  
Keyword(s):  
Formic Acid ◽  
Structure Determination ◽  
Reaction Products ◽  
Acid Reaction

NMR Structure Determination of a Segmentally Labeled Glycoprotein Using in Vitro Glycosylation

2009 ◽  
Vol 131 (3) ◽  
pp. 1274-1281 ◽  
Author(s):  
Vadim Slynko ◽  
Mario Schubert ◽  
Shin Numao ◽  
Michael Kowarik ◽  
Markus Aebi ◽  
...  
Keyword(s):  
Structure Determination ◽  
Nmr Structure ◽  
Nmr Structure Determination

scholarly journals Rapid Structure Determination of Bioactive 4″-Tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC-SPE/Cryo NMR and MS

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6316
Author(s):  
Iva Habinovec ◽  
Ivana Mikulandra ◽  
Lucia Ema Sekula ◽  
Jana Gašperov ◽  
Saša Kazazić ◽  
...  
Keyword(s):  
Structure Determination ◽  
Concentration Level ◽  
Antibacterial Activities ◽  
Bacterial Strains ◽  
Isolation And Identification ◽  
Low Concentration ◽  
Multiple Trapping ◽  
Further Development

LC-SPE/cryo NMR and MS methodologies have been developed and employed for a rapid structure determination of 4″-tetrahydrofurfuryl macrozone reaction mixture components. Macrozones, novel conjugates of azithromycin, and thiosemicarbazones have shown very good in vitro antibacterial activities against susceptible and some resistant bacterial strains and are promising agents for further development. The post-column multiple trapping of the chromatographically separated reaction mixture components on the SPE cartridges increased the sensitivity and together with cryogenically cooled NMR probe made it possible to identify and structurally characterize main 4″-tetrahydrofurfuryl macrozone reaction mixture compounds including those present at very low concentration level. This approach has several advantages over a classical off-line procedure, efficiency and low solvent consumption being the two most important ones. All identified components were process-related. It has been demonstrated that two different kinds of compounds with respect to structure were identified, i.e., macrolide-related and thiosemicarbazone-related ones. This methodology can serve as a platform for reliable and effective macrolides reaction components structure profiling, serving as both isolation and identification tools.

Sign in / Sign up

Export Citation Format

Share Document