X-Ray crystallography studies and CP-MAS 13C NMR spectroscopy on the solid-state stereochemistry of diphenhydramine hydrochloride, an antihistaminic drug

1990 ◽  
pp. 1205 ◽  
Author(s):  
Robert Glaser ◽  
Knut Maartmann-Moe
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
X Ray ◽  
X Ray Crystallography ◽  
Diphenhydramine Hydrochloride ◽  
Antihistaminic Drug ◽  
Cp Mas 13C Nmr

Zur Struktur von Hydroxy-5-phenyl-furanonen: Lösungs-NMR, Festkörper-13C-NMR und Röntgenstruktur im Vergleich / On the Structure of Hydroxy-5-phenyl-furanone Derivatives: NMR Spectroscopy in Solution and High Resolution Solid State 13C NMR Spectroscopy in Relation to X-Ray Crystallography

1993 ◽  
Vol 48 (10) ◽  
pp. 1372-1380 ◽  
Author(s):  
M. Schmidt ◽  
K. Albert ◽  
R. Brindle ◽  
C. Maichle-Mössmer ◽  
K. Eger
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
13C Nmr ◽  
Solid State Nmr ◽  
Dehydroascorbic Acid ◽  
13C Nmr Spectroscopy ◽  
Crystal Structure Analysis ◽  
Nmr Spectrum ◽  
X Ray ◽  
X Ray Crystallography

The structure of (5H)-2-Amino-3-hydroxy-5-phenyl-furan-4-one (lb) was determined by NMR-spectroscopy in solution and in the solid state. The structure of its oxidation product, 3,4-Dihydro-3,3,4,4-tetrahydroxy-5-phenyl-furan-2(5H)-one (7), given in the literature as 5-Phenyl-2,3,4-(5H)-furan-trione, was determined by NMR spectroscopy and crystal structure analysis. The solid state NMR spectrum of 7 was compared to the spectrum of dehydroascorbic acid

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