The role of the ligand in chrysotherapy: a kinetic study of 199Au- and 35S-labelled myocrisin and auranofin

1989 ◽  
pp. 53 ◽  
Author(s):  
Stephanie M. Cottrill ◽  
Harbans L. Sharma ◽  
David B. Dyson ◽  
R. V. Parish ◽  
Charles A. McAuliffe
Keyword(s):  
Kinetic Study

Kinetic Study on Role of Ditelluride in Organotellurium-Mediated Living Radical Polymerization (TERP)

2007 ◽  
Vol 40 (6) ◽  
pp. 1881-1885 ◽  
Author(s):  
Yungwan Kwak ◽  
Miho Tezuka ◽  
Atsushi Goto ◽  
Takeshi Fukuda ◽  
Shigeru Yamago
Keyword(s):  
Kinetic Study ◽  
Radical Polymerization ◽  
Living Radical Polymerization

On the role of monomeric vanadyl species in toluene oxidation over V2O5/TiO2 catalysts: a kinetic study using the TAP reactor

2004 ◽  
Vol 91-92 ◽  
pp. 143-147 ◽  
Author(s):  
C Freitag ◽  
S Besselmann ◽  
E Löffler ◽  
W Grünert ◽  
F Rosowski ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Toluene Oxidation

scholarly journals Design, Synthesis, Molecular Docking, and Kinetic Study of 3-Amino-2,4-Diarylbenzo[4,5]Imidazo[1,2-a]Pyrimidines as Novel, Potent Α-Glucosidase Inhibitor

2021 ◽  
Author(s):  
Fariba Peytam ◽  
Ghazaleh Takalloobanafshi ◽  
Toktam Saadattalab ◽  
Zahra Emamgholipour ◽  
Maryam Norouzbahari ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Kinetic Study ◽  
Docking Study ◽  
Type Ii Diabetes Mellitus ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Drug Candidates ◽  
Glucosidase Inhibitors

Abstract In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a-ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile protocol has been resulted into the desirable compounds with a wide substrate scope in good to excellent yields. Afterwards, their α-glucosidase inhibitory activities were investigated. Showing IC50 values ranging from 16.4 ± 0.36 µM to 297.0 ± 1.2 µM confirmed their excellent potency to inhibit α-glucosidase which may provide new drug candidates in the treatment of type II diabetes mellitus. Among various synthesized 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines, compound 3k exhibited the highest potency against α-glucosidase (IC50 = 16.4 ± 0.36 μM) which was 45.7 times more potent than acarbose as standard inhibitor (IC50 = 750.0 ± 1.5 μM). Moreover, the role of amine moiety on the observed activity was studied through substituting with chlorine and hydrogen resulted into a considerable deterioration on the inhibitory activity. Kinetic study and molecular docking study have confirmed the in-vitro results.

Sign in / Sign up

Export Citation Format

Share Document