The biosynthesis of tropic acid. Part 6. Enantioselective, intact incorporation of (R)-(+)-3-phenyllactic acid into the tropic acid ester alkaloids of Datura

1995 ◽  
pp. 487 ◽  
Author(s):  
Morteza Ansarin ◽  
Jack G. Woolley
Keyword(s):  
Acid Ester ◽  
Phenyllactic Acid ◽  
Tropic Acid

Phenyllactic acid but not tropic acid is an intermediate in the biosynthesis of tropane alkaloids in Datura and Brugmansia transformed root cultures

Planta ◽  
1994 ◽  
Vol 194 (1) ◽  
Author(s):  
RichardJ. Robins ◽  
JackG. Woolley ◽  
Morteza Ansarin ◽  
John Eagles ◽  
BrianJ. Goodfellow
Keyword(s):  
Tropane Alkaloids ◽  
Root Cultures ◽  
Phenyllactic Acid ◽  
Tropic Acid ◽  
Transformed Root Cultures

XP-23829, a Novel Fumaric Acid Ester, is Efficacious in Reducing Psoriatic Lesions: Results from a Phase 2 Randomized Controlled Study

2017 ◽  
Vol 1 ◽  
pp. s33 ◽  
Author(s):  
Alice B Gottlieb ◽  
Caitriona Ryan ◽  
Richard Kim ◽  
Aftab Alam ◽  
Sagar Munjal ◽  
...  
Keyword(s):  
Fumaric Acid ◽  
Acid Ester ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Phase 2 ◽  
Randomized Controlled ◽  
Fumaric Acid Ester ◽  
Psoriatic Lesions

Abstract Not Available

Eco-Friendly Synthesis of Peptides Using Fmoc-Amino Acid Chlorides as Coupling Agent Under Biphasic Condition

2020 ◽  
Vol 27 ◽  
Author(s):  
Santosh Y. Khatavi ◽  
K. Kantharaju
Keyword(s):  
Amino Acid ◽  
Acid Chloride ◽  
Acid Ester ◽  
Analytical Techniques ◽  
Peptide Bond ◽  
Amino Acid Ester ◽  
Acid Chlorides ◽  
Peptide Bond Formation ◽  
Green Protocol ◽  
Additional Base

Background: Agro-waste derived solvent media act as a greener process for the peptide bond formation using Nα - Fmoc-amino acid chloride and amino acid ester salt with in situ neutralization and coupling under biphasic condition. The Fmoc-amino acid chlorides are prepared by the reported procedure of freshly distilled SOCl2 with dry CH2Cl2. The protocol found many added advantages such as neutralization of amino acid ester salt and not required additional base for the neutralization, and directly coupling take place with Fmoc-amino acid chloride gave final product dipeptide ester in good to excellent yields. The protocol occurs with complete stereo chemical integrity of the configuration of substrates. Here, we revisited Schotten-Baumann condition, instead of using inorganic base. Objective: To develop green protocol for the synthesis of peptide bond using Fmoc-amino acid chloride with amino acid esters salt. Methods: The final product isolated is analyzed in several spectroscopic and analytical techniques such as FT-IR, 1H-, 13CNMR, Mass spectrometry and RP-HPLC to check stereo integrity and purity of the product. Conclusion: The present method developed greener using natural agro-waste (lemon fruit shell ash) derived solvent medium for the reaction and not required chemical entity.

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