Synthetic approaches towards the novel 1,3-dioxo-1,2-dithiolane moiety in the antitumour antibiotic substance leinamycin

1992 ◽  
pp. 1215 ◽  
Author(s):  
Gerald Pattenden ◽  
Anthony J. Shuker
Keyword(s):  
The Novel ◽  
Antibiotic Substance ◽  
Synthetic Approaches

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

2020 ◽  
Vol 28 (2) ◽  
pp. 213-237 ◽  
Author(s):  
Andrea Mastinu ◽  
Giovanni Ribaudo ◽  
Alberto Ongaro ◽  
Sara Anna Bonini ◽  
Maurizio Memo ◽  
...  
Keyword(s):  
In Silico ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
The Novel ◽  
In Silico Studies ◽  
Computational Data ◽  
Synthetic Approaches ◽  
Analytical Approaches ◽  
Yield Sensitivity ◽  
Therapeutic Profile

: Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.

Total Synthesis of Camptothecins: An Update

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1134-1150 ◽  
Author(s):  
Fen-Er Chen ◽  
Lei Chen
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Enantioselective Synthesis ◽  
The Novel ◽  
Asymmetric Dihydroxylation ◽  
New Methods ◽  
Considerable Research ◽  
Catalytic Asymmetric ◽  
Synthetic Approaches ◽  
Asymmetric Hydroxylation

Over the last few decades, considerable research efforts have been directed toward the development of effective chemical syntheses of camptothecin and its analogs. The last comprehensive review of this area was published in 2003 and many effective new methods have since been reported for the stereoselective synthesis of the camptothecin alkaloids. In this account, we have summarized most of the novel synthetic approaches developed for the synthesis of camptothecins during the last decade. We have focused on strategies for the construction of the pentacyclic ring system and the different methods used to install the chiral quaternary center on the E ring of camptothecin.1 Introduction2 Synthesis of Racemic Camptothecins3 Enantioselective Synthesis of Camptothecins3.1 Sharpless Asymmetric Dihydroxylation3.2 Catalytic Asymmetric Cyanosilylation3.3 Auxiliary-Induced Asymmetric Carbonyl Addition3.4 Catalytic Asymmetric Ethylation3.5 Asymmetric Hydroxylation4 Conclusion

Molten-State Nitration of Substituted Imidazoles: New Synthetic Approaches to the Novel Melt-Cast Energetic Material, 1-Methyl-2,4,5-trinitroimidazole

Synthesis ◽  
2011 ◽  
Vol 2011 (17) ◽  
pp. 2859-2864 ◽  
Author(s):  
Raja Duddu ◽  
Reddy Damavarapu ◽  
Mao-Xi Zhang ◽  
Nathaniel Gelber
Keyword(s):  
Energetic Material ◽  
The Novel ◽  
Molten State ◽  
Synthetic Approaches

FR901483: Synthetic Efficiency Remains a Challenge

Synthesis ◽  
2019 ◽  
Vol 51 (11) ◽  
pp. 2237-2251 ◽  
Author(s):  
Zhuwei Ruan ◽  
Cheng Li ◽  
Defeng Shen ◽  
Sha-Hua Huang ◽  
Ran Hong
Keyword(s):  
Drug Development ◽  
Total Synthesis ◽  
Phosphate Group ◽  
Synthetic Methods ◽  
The Novel ◽  
The Core ◽  
Nitrogen Center ◽  
Tricyclic Core ◽  
Synthetic Approaches ◽  
Tertiary Nitrogen

FR901483 is a unique alkaloid bearing an aza-tricyclic structure, a phosphate group, and a congested tertiary nitrogen center. This alkaloid was reported to be a potent immunosuppressant with antimetabolite ability. The unprecedented architecture has captured imagination of synthetic chemists since its isolation in 1996. To date, ten total or formal syntheses and several synthetic approaches to access the tricyclic core skeleton have been reported. In this review, we highlight the novel synthetic methods and strategies and discuss the synthetic challenge for meeting the criteria of drug development.1 Introduction2 Bioinspired Total Synthesis of FR9014833 Non-bioinspired Approaches toward FR9014834 Various Tactics for Accessing the Core Skeleton5 Challenges for Efficiency

Pyridyl disulfide-based thiol–disulfide exchange reaction: shaping the design of redox-responsive polymeric materials

2020 ◽  
Vol 11 (48) ◽  
pp. 7603-7624
Author(s):  
Ismail Altinbasak ◽  
Mehmet Arslan ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Exchange Reaction ◽  
Functional Materials ◽  
Polymeric Materials ◽  
Disulfide Exchange ◽  
Redox Responsive ◽  
Synthetic Approaches

This review provides an overview of synthetic approaches utilized to incorporate the thiol-reactive pyridyl-disulfide motif into various polymeric materials, and briefly highlights its utilization to obtain functional materials.

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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