Dehalogenation of 1-halogenothienyl-di- and -tetra-hydroisoquinolines by sodium methoxide in dimethyl sulphoxide

1985 ◽  
pp. 275 ◽  
Author(s):  
John M. Barker ◽  
Patrick R. Huddleston ◽  
Jannette Clephane ◽  
Michael L. Wood ◽  
David Holmes
Keyword(s):  
Sodium Methoxide ◽  
Dimethyl Sulphoxide

Phosphonium salts. III. The action of cyanide ion and other nucleophiles on some bis-phosphonium salts

1969 ◽  
Vol 22 (7) ◽  
pp. 1405 ◽  
Author(s):  
JJ Brophy ◽  
MJ Gallagher
Keyword(s):  
Sodium Azide ◽  
Sodium Methoxide ◽  
Sodium Acetate ◽  
Potassium Cyanide ◽  
Dimethyl Sulphoxide ◽  
High Yield ◽  
Phosphonium Salts ◽  
Elimination Reaction ◽  
Cyanide Ion ◽  
Reaction Proceeds

Cyclic and acyclic bis-phosphonium salts with a two-carbon bridge are smoothly cleaved to phosphines in high yield by potassium cyanide in dimethyl sulphoxide. Evidence is presented that the reaction proceeds by an elimination-addition sequence. An elimination reaction also occurs when sodium methoxide, sodium azide, sodium acetate, and triethylamine react with ethane-1,2-bis(tri-phenylphosphonium) dibromide. ��� In a novel reaction, triphenylphosphine is converted into its oxide by a mixture of sodium azide and dimethyl sulphoxide.

Acridone studies. X. Reactions of the isomeric Bromo-10-methylacridones with sodium methoxide in methanol and in dimethyl sulphoxide

1972 ◽  
Vol 25 (3) ◽  
pp. 585 ◽  
Author(s):  
DKC Hodgeman ◽  
RH Prager
Keyword(s):  
Sodium Methoxide ◽  
Dimethyl Sulphoxide ◽  
Radical Chain

The isomeric 1-, 2-, 3-, and 4-bromo-10-methylacridones undergo a radical chain reduction to 10-methylacridone in the presence of sodium methoxide in methanol. Evidence for the mechanism is presented. In the presence of methanol-free dimethyl sulphoxide, the 1- and 3-bromo-10-methylacridones are cleanly converted by sodium methoxide into the respective methoxy compounds, and the rates have been measured at 40�. In the same solvent, the 2- and 4-bromo isomers are again reduced by sodium methoxide.

Acridone studies. XI. Reaction of some Polyalkoxy-10-methylacridones with sodium methoxide in methanol and in dimethyl sulphoxide

1972 ◽  
Vol 25 (8) ◽  
pp. 1751 ◽  
Author(s):  
DKC Hodgeman ◽  
RH Prager
Keyword(s):  
Sodium Methoxide ◽  
Activation Parameters ◽  
Dimethyl Sulphoxide ◽  
Aromatic Nucleus ◽  
Methylene Group

The isomeric dimethoxymethylenedioxy-10-methylacridone react with sodium methoxide in methanol to give a number of products which have been characterized. Substitution occurs on both the aromatic nucleus and the methylene group. In dimethyl sulphoxide opening of the methylenedioxy ring occurs exclusively and the rates and activation parameters of this reaction have been measured.

Immunocytochemical localization of desmin and vimentin in chick embryonic myocardial cells

1990 ◽  
Vol 48 (3) ◽  
pp. 448-449
Author(s):  
Yukiko Sugi
Keyword(s):  
Sodium Methoxide ◽  
Intermediate Filament Protein ◽  
Chick Embryos ◽  
Immunocytochemical Localization ◽  
Myocardial Cells ◽  
Immunofluorescence Study ◽  
Immunofluorescent Localization ◽  
Rabbit Igg ◽  
Semithin Sections ◽  
Filament Protein

In cultured skeletal muscle cells of chick, one intermediate filament protein, vimentin, is primarily formed and then synthesis of desmin follows. Coexistence of vimentin and desmin has been immunocytochemically confirmed in chick embryonic skeletal musclecells. Immunofluorescent localization of vimentin and desmin has been described in developing myocardial cells of hamster. However, initial localization of desmin and vimentin in early embryonic heart has not been reported in detail. By quick-freeze deep-etch method a loose network of intermediate filaments was revealed to exist surrounding myofibrils. In this report, immunocytochemical localization of desmin and vimentin is visualized in early stages of chick embryonic my ocardium.Chick embryos, Hamburger-Hamilton (H-H) stage 8 to hatch, and 1 day old postnatal chicks were used in this study. For immunofluorescence study, each embryo was fixed with 4% paraformaldehyde and embedded in Epon 812. De-epoxinized with sodium methoxide, semithin sections were stained with primary antibodies (rabbit anti-desmin antibody and anti-vimentin antibody)and secondary antibody (RITC conjugated goat-anti rabbit IgG).

Solvation of ions by dipolar aprotic solvents and water. A CNDO/2 study

1985 ◽  
Vol 50 (11) ◽  
pp. 2493-2508 ◽  
Author(s):  
Petr Kyselka ◽  
Zdeněk Havlas ◽  
Ivo Sláma
Keyword(s):  
Binary Mixtures ◽  
Quantum Chemical ◽  
Chemical Method ◽  
Molecular Structures ◽  
Dimethyl Sulphoxide ◽  
Ternary Mixtures ◽  
Aprotic Solvents ◽  
Quantum Chemical Method ◽  
Solvation Of Ions ◽  
Dipolar Aprotic Solvents

Solvation of Li+, Be2+, Na+, Mg2+, and Al3+ ions has been studied in binary mixtures with dimethyl sulphoxide, dimethylformamide, acetonitrile and water, and in ternary mixtures of the organic solvents with water. The CNDO/2 quantum chemical method was used to calculate the energies of solvation, molecular structures and charge distributions for the complexes acetonitrile...ion (1:1, 2:1, 4:1), dimethyl sulphoxide...ion (1:1), dimethylformamide...ion (1:1), and acetonitrile (dimethyl sulphoxide, dimethylformamide)...ion...water (1:1:1).

Reaction of 1,4-dibromohexafluoro-2-butene with O- and N-nucleophiles

1988 ◽  
Vol 53 (3) ◽  
pp. 619-625 ◽  
Author(s):  
Ivan Hemer ◽  
Věra Moravcová ◽  
Václav Dědek
Keyword(s):  
Kinetic Study ◽  
Sodium Methoxide ◽  
Allylic Rearrangement ◽  
Rearrangement Product

Reaction of 1,4-dibromohexafluoro-2-butene (I) with sodium methoxide, ethoxide or isopropoxide in the corresponding alcohols proceeds with allylic rearrangement under formation of 3-alkoxy-4-bromohexafluoro-1-butenes II-IV. A kinetic study has proven the SN2’ mechanism for reaction of I with potassium phenoxide leading to 4-bromo-3-phenoxyhexafluoro-1-butene (V). Also the reaction of I with ammonia, affording 3-amino-4-bromo-2,4,4-trifluoro-2-butenenitrile (IX), is compatible with the allylic rearrangement by SN2’ mechanism. On the contrary, reaction of I with diethylamine gave no rearrangement product and, after hydrolysis, afforded N,N-diethyl-4-bromo-2,3,3,4,4-pentafluorobutanamide (XVI) and N,N-diethyl-4-bromo-2,3,4,4-tetrafluoro-2-butenamide (XVII) in the ratio 85:15.

Viscosity, electrical conductivity and density of the system ammonium nitrate-dimethyl sulphoxide

1984 ◽  
Vol 49 (5) ◽  
pp. 1109-1115
Author(s):  
Jindřich Novák ◽  
Zdeněk Kodejš ◽  
Ivo Sláma
Keyword(s):  
Electrical Conductivity ◽  
Aqueous Solutions ◽  
Ammonium Nitrate ◽  
Transport Properties ◽  
Calcium Nitrate ◽  
Dimethyl Sulphoxide ◽  
Present System ◽  
Empirical Equations ◽  
Concentrated Solutions ◽  
Nitrate Solutions

The density, viscosity, and electrical conductivity of highly concentrated solutions of ammonium nitrate in dimethyl sulphoxide have been determined over the temperature range 10-60 °C and the concentration range 7-50 mol% of the salt. The variations in the quantities as a function of temperature and concentration have been correlated by empirical equations. A comparison is made between the transport properties for the present system, aqueous solutions of ammonium nitrate, and calcium nitrate solutions in dimethyl sulphoxide.

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