Carbon-13 nuclear magnetic resonance assignments and biosynthesis of the mycotoxin ochratoxin A

1980 ◽  
pp. 52 ◽  
Author(s):  
Amelia E. de Jesus ◽  
Pieter S. Steyn ◽  
Robert Vleggaar ◽  
Philippus L. Wessels
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Ochratoxin A ◽  
Resonance Assignments ◽  
Nuclear Magnetic

13C nuclear magnetic resonance and reactivity of 4H-3,1-benzoxazin-4-ones

1988 ◽  
Vol 66 (3) ◽  
pp. 416-419 ◽  
Author(s):  
Valerie J. Robinson ◽  
Robin W. Spencer
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Resonance Assignments ◽  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
13C Nuclear Magnetic Resonance ◽  
Tissue Degradation ◽  
Alternate Substrate ◽  
Nuclear Magnetic

Complete carbon-13 nuclear magnetic resonance assignments have been made for 22 4H-3,1-benzoxazin-4-ones. These compounds are alternate substrate inhibitors of human leukocyte elastase, a serine protease involved in tissue degradation. Correlations between the carbon chemical shifts and rates of alkaline hydrolysis are consistent with hydrolysis via attack at C4, and are also useful in the selection of parameters for structure–activity analysis.

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