40. Aspects of stereochemistry. Part III. Acidic and basic hydrolysis of some diol cyclic sulphates and related compounds

1960 ◽  
pp. 201 ◽  
Author(s):  
J. S. Brimacombe ◽  
A. B. Foster ◽  
E. B. Hancock ◽  
W. G. Overend ◽  
M. Stacey
Keyword(s):  
Basic Hydrolysis ◽  
Hydrolysis Of ◽  
Related Compounds

Kinetics and Mechanism of the Basic Hydrolysis of Indomethacin and Related Compounds: A Reevaluation

1983 ◽  
Vol 72 (9) ◽  
pp. 1075-1076 ◽  
Author(s):  
Antonio Cipiciani ◽  
Cynthia Ebert ◽  
Paolo Linda ◽  
Fulvio Rubessa ◽  
Gianfranco Savelli
Keyword(s):  
Kinetics And Mechanism ◽  
Basic Hydrolysis ◽  
Hydrolysis Of ◽  
Related Compounds

Micellar Effects on the basic Hydrolysis of Indomethacin and Related Compounds

1985 ◽  
Vol 74 (11) ◽  
pp. 1184-1187 ◽  
Author(s):  
Antonio Cipiciani ◽  
Cynthia Ebert ◽  
Raimondo Germani ◽  
Paolo Linda ◽  
Mara Lovrecich ◽  
...  
Keyword(s):  
Micellar Effects ◽  
Basic Hydrolysis ◽  
Hydrolysis Of ◽  
Related Compounds

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds

2015 ◽  
Vol 68 (2) ◽  
pp. 224 ◽  
Author(s):  
Hiroyasu Taguchi ◽  
Daijiro Yanagisawa ◽  
Shigehiro Morikawa ◽  
Koichi Hirao ◽  
Nobuaki Shirai ◽  
...  
Keyword(s):  
Parent Compound ◽  
Amyloid Plaques ◽  
Enol Form ◽  
19F Nmr ◽  
Enolic Form ◽  
Curcumin Derivatives ◽  
Alkyl Groups ◽  
Alzheimer Brain ◽  
Hydrolysis Of ◽  
Related Compounds

1,7-Bis(4′-hydroxy-3′-trifluoromethoxyphenyl)-1,6-heptadiene-3,5-dione (2a), related to curcumin, and thirteen 4-substituted derivatives were prepared and their keto/enol ratio in DMSO[D6] was determined by 19F NMR because the enolic form of these related curcumins had been shown to bind to amyloid plaques in the Alzheimer brain. The parent compound and the 4-ethoxycarbonyl derivative were almost 100 % in the enolic form that contains a conjugated hepta-1,4,6-trien-3-on-5-ol backbone. Enolisation decreased to varying amounts in the derivatives that had 4-substituted alkyl groups. Attempts to prepare the 4-hydroxypropyl derivative by hydrolysis of O-methoxymethyl 2m or O-tetrahydropyranyloxy 2n protected derivatives led to cyclised products. A related pyrimidine compound 6b that mimicked a fixed enol form was also prepared.

ChemInform Abstract: THE UNUSUALLY MILD AND FACILE BASIC HYDROLYSIS OF N-NITROSO-2-(METHYLAMINO)ACETONITRILE

1977 ◽  
Vol 8 (9) ◽  
pp. no-no
Author(s):  
S. K. CHANG ◽  
G. W. HARRINGTON ◽  
H. S. VEALE ◽  
D. SWERN
Keyword(s):  
Basic Hydrolysis ◽  
Hydrolysis Of
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