The alkaline hydrolysis of alkyl esters of anthraquinone-1- and -2-carboxylic acids

1971 ◽  
pp. 202 ◽  
Author(s):  
P. H. Gore ◽  
A. Rahim ◽  
D. N. Waters
Keyword(s):  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Alkyl Esters ◽  
Hydrolysis Of

Isocarbostyrils. II. The Conversion of 2-Methyl-4-acyl-5-nitroisocarbostyrils to 2-Substituted Indole-4-carboxylic Acids

1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Mannich Reaction ◽  
Reductive Cyclization ◽  
Acid Catalyzed ◽  
Acid Anhydrides ◽  
Hydrolysis Of ◽  
Derivatives Of

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.

Ribonucleosides of 3-amino- and 3,5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions

1986 ◽  
Vol 51 (7) ◽  
pp. 1512-1531 ◽  
Author(s):  
Maria K. Spassova ◽  
Antonín Holý ◽  
Milena Masojídková
Keyword(s):  
Carboxylic Acid ◽  
Acid Hydrolysis ◽  
Carboxylic Acids ◽  
Sodium Salt ◽  
Alkaline Hydrolysis ◽  
Trimethylsilyl Derivative ◽  
Open Chain ◽  
Silyl Derivatives ◽  
Hydrolysis Of

Bis(trimethylsilyl) derivative of ethyl 3-aminopyrazole-4-carboxylate (VI) and tris(trimethylsilyl) derivative of ethyl 3,5-diaminopyrazole-4-carboxylate (VII) on reaction with 2,3,5-tri-O-benzoyl-D-ribofuranolyl chloride and subsequent debenzoylation afforded the respective β-D-ribofuranosyl derivatives VIIIa and Xa. Their alkaline hydrolysis led to 1-(β-D-ribofuranosyl)-3-aminopyrazole-4-carboxylic acid (VIIIc) and 1-(β-D-ribofuranosyl)-3,5-diaminopyrazole-4-carboxylic acid (Xb). The esters VIIIa and Xa were not ammonolyzed under normal conditions. Contrary to nucleosidation of the silyl derivatives VI and VII, sodium salt of ethyl 3-aminopyrazole-4-carboxylate was alkylated with 4-chloromethyl-2,2-dimethyl-1,3-dioxolane (XI) or 5-(p-toluenesulfonyloxy)-1,3-dioxane (XVIIb) to give a mixture of the N-isomeric derivatives XIIIa, XIXa and XIIa, XVIIIa, respectively; sodium salt of the 3,5-diamino derivative V reacted with these synthons under formation of the corresponding compounds XIIIb and XXa. Subsequent alkaline and acid hydrolysis of XIIa and XIIIb gave the open-chain analogs of nucleosides XV and XVI. The N-(1,3-dioxan-5-yl) derivatives XVIIIc and XXa resisted acid hydrolysis, giving rise only to carboxylic acids XVIIIb and XXb.

scholarly journals Kinetics of the Alkaline Hydrolysis of Aminoalkyl Esters of Carboxylic Acids.

1962 ◽  
Vol 16 ◽  
pp. 1927-1935 ◽  
Author(s):  
Bertil Hansen ◽  
Peter Klæboe ◽  
Lynn Wolf ◽  
Carl Djerassi ◽  
Olof Theander ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Esters Of Carboxylic Acids ◽  
Kinetics Of ◽  
Hydrolysis Of
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