Chemical combinatorics. Part 3.—Stereochemical invariance law and the statistical mechanics of flexible molecules

M. Gordon; W. B. Temple

doi:10.1039/f29736900282

Chemical combinatorics. Part 3.—Stereochemical invariance law and the statistical mechanics of flexible molecules

Journal of the Chemical Society Faraday Transactions 2 Molecular and Chemical Physics ◽

10.1039/f29736900282 ◽

1973 ◽

Vol 69 (0) ◽

pp. 282-297 ◽

Cited By ~ 10

Author(s):

M. Gordon ◽

W. B. Temple

Keyword(s):

Statistical Mechanics ◽

Flexible Molecules

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On the study of crystal growth via interfacial analysis and string optimization

CrystEngComm ◽

10.1039/c3ce42657b ◽

2014 ◽

Vol 16 (27) ◽

pp. 6224-6233 ◽

Cited By ~ 2

Author(s):

Adam Idu Jion ◽

Raj Rajagopalan

Keyword(s):

Crystal Growth ◽

Statistical Mechanics ◽

Computer Simulations ◽

Activation Energies ◽

Flexible Molecules ◽

Solution Interface ◽

Interfacial Analysis

Mathematical ‘strings’ can be used with computer simulations and statistical mechanics to calculate the fraction of growth units and activation energies of flexible molecules present at the crystal–solution interface.

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Cryogenic atomic force microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100084570 ◽

1991 ◽

Vol 49 ◽

pp. 54-55

Author(s):

K. A. Fisher ◽

M. G. L. Gustafsson ◽

M. B. Shattuck ◽

J. Clarke

Keyword(s):

Room Temperature ◽

Rapid Freezing ◽

Cryogenic Temperatures ◽

Soft Or ◽

Electrically Conductive ◽

Force Microscopy ◽

Flexible Molecules ◽

Advantages And Disadvantages ◽

Atomic Force ◽

Chemical Perturbation

The atomic force microscope (AFM) is capable of imaging electrically conductive and non-conductive surfaces at atomic resolution. When used to image biological samples, however, lateral resolution is often limited to nanometer levels, due primarily to AFM tip/sample interactions. Several approaches to immobilize and stabilize soft or flexible molecules for AFM have been examined, notably, tethering coating, and freezing. Although each approach has its advantages and disadvantages, rapid freezing techniques have the special advantage of avoiding chemical perturbation, and minimizing physical disruption of the sample. Scanning with an AFM at cryogenic temperatures has the potential to image frozen biomolecules at high resolution. We have constructed a force microscope capable of operating immersed in liquid n-pentane and have tested its performance at room temperature with carbon and metal-coated samples, and at 143° K with uncoated ferritin and purple membrane (PM).

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