3D printing of tough double-network hydrogel and using it as scaffold to construct tissue-like hydrogel composite

2022 ◽  
Author(s):  
Cong Du ◽  
jian Hu ◽  
Xinyu Wu ◽  
Huimin Shi ◽  
Hai Chao Yu ◽  
...  
Keyword(s):  
3D Printing ◽  
Biological Tissues ◽  
Double Network ◽  
Structural Support ◽  
Hydrogel Composite

To mimic biological tissues with large toughness such as cartilage, it is highly desired to fabricate stable and tough hydrogels with intricate shapes to act as a structural support. Extrusion-based...

scholarly journals Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador
Keyword(s):  
Optical Properties ◽  
3D Printing ◽  
Clinical Training ◽  
Three Dimensional ◽  
Biological Tissues ◽  
3D Bioprinting ◽  
Technology Intelligence ◽  
Biomedical Device ◽  
Tissue Phantoms ◽  
Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

Effects of Friction Coefficient and Receptor Number on Cell-Substrate Interactions During Migration

2010 ◽  
Author(s):  
Henry C. Wong ◽  
William C. Tang
Keyword(s):  
Cell Migration ◽  
Cancer Metastasis ◽  
Element Model ◽  
Biological Tissues ◽  
Substrate Interactions ◽  
Strain Behavior ◽  
Structural Support ◽  
Research Areas ◽  
Cell Substrate ◽  
A Cell

Biological tissues are composed of cells that adhere to the extracellular matrix (ECM) via cell-surface integrin receptors that bind to specific proteins, such as fibronectin, embedded in the matrix. In this manner, the ECM functions as a structural support for the attached cells, and mechanical forces are able to be transmitted from the cell to the ECM and vice versa [1]. Cell migration, a process that is highly dependent on these mechanical interactions, is important for many normal biological processes and diseases that occur in the human body, which include embryonic development, immune response, would healing, and cancer invasion [2]. Though many continuum models of cell migration have been proposed, there is still a need for a model that can be used to quantitatively understand the mechanical factors that can influence the movement of a cell on a substrate. This would be invaluable to the research areas of tissue engineering as well as cancer metastasis. We utilized a finite element model to elucidate the mechanism of cell-substrate interactions for a cell that consistently migrates in a single direction. Our model follows the approach taken by Gracheva and Othmer [2], but we extended their model to describe two-dimensional plane strain behavior.

scholarly journals 3D Printing of Strong and Tough Double Network Granular Hydrogels

2020 ◽  
pp. 2005929
Author(s):  
Matteo Hirsch ◽  
Alvaro Charlet ◽  
Esther Amstad
Keyword(s):  
3D Printing ◽  
Double Network

scholarly journals 3D printable SiO2 nanoparticle ink for patient specific bone regeneration

RSC Advances ◽  
2019 ◽  
Vol 9 (41) ◽  
pp. 23832-23842 ◽  
Author(s):  
Uday Kiran Roopavath ◽  
Raghav Soni ◽  
Urbashi Mahanta ◽  
Atul Suresh Deshpande ◽  
Subha Narayan Rath
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Patient Specific ◽  
Hydrogel Composite ◽  
Sio2 Nanoparticle ◽  
Nanoparticle Ink

3D printing of a complex and irregular virtual defect using SiO2 nanoparticle and hydrogel composite ink for patient specific defect fabrication.

scholarly journals Review on 3d Printing of Biological Tissues and the Materialization

2020 ◽  
Vol 988 ◽  
pp. 012128
Author(s):  
S. Adharsh ◽  
A. Abul Kalam Azad ◽  
Fathima Yasin Fahmidha ◽  
V. Dhinakaran ◽  
T. Jagadeesha
Keyword(s):  
3D Printing ◽  
Biological Tissues

Tough Double Network Hydrogel and Its Biomedical Applications

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Takayuki Nonoyama ◽  
Jian Ping Gong
Keyword(s):  
Biomedical Applications ◽  
Biomedical Application ◽  
Early Stage ◽  
Biological Tissues ◽  
Annual Review ◽  
Publication Date ◽  
Connective Tissues ◽  
Double Network ◽  
High Tension ◽  
Tension And Compression

Soft and wet hydrogels have many similarities to biological tissues, though their mechanical fragility had been one of the biggest obstacles in biomedical applications. Studies and developments in double network (DN) hydrogels have elucidated how to create tough gels universally based on sacrificial bond principles and opened a path for biomedical application of hydrogels in regenerative medicine and artificial soft connective tissues, such as cartilage, tendon, and ligament, which endure high tension and compression. This review explores a universal toughening mechanism for and biomedical studies of DN hydrogels. Moreover, because the term sacrificial bonds has been mentioned often in studies of bone tissues, consisting of biomacromolecules and biominerals, recent studies of gel–biomineral composites to understand early-stage osteogenesis and to simulate bony sacrificial bonds are also summarized. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 12 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

(Invited) Fabrication of Polymer Gels with Double Network Using Multi-Material 2/3D Printing

2020 ◽  
Vol MA2020-02 (69) ◽  
pp. 3707-3707
Author(s):  
Yosuke Watanabe ◽  
Fumiya Shiga ◽  
MD Nahin Islam Shiblee ◽  
Jun Ogawa ◽  
Ajit Khosla ◽  
...  
Keyword(s):  
3D Printing ◽  
Polymer Gels ◽  
Double Network

Development of a Zeolite/Polymer‐Based Hydrogel Composite through Photopolymerization for 3D Printing Application

2021 ◽  
pp. 2100129
Author(s):  
Yijun Zhang ◽  
Shaohui Liu ◽  
Hong Chen ◽  
Ludovic Josien ◽  
Gautier Schrodj ◽  
...  
Keyword(s):  
3D Printing ◽  
Hydrogel Composite
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