Mussel inspired injectable chitosan hydrogel modified with catechol for cell adhesion and cartilage defect repair

2022 ◽  
Author(s):  
Siqi Zhou ◽  
Zhongwu Bei ◽  
jian wei ◽  
xinxin yan ◽  
haiyan wen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Defect ◽  
Effective Strategy ◽  
Articular Cartilage Defect ◽  
Chitosan Hydrogel ◽  
The Poor ◽  
Cartilage Defect Repair ◽  
Defect Repair ◽  
And Cartilage

Repairing articular cartilage defect is a great challenge due to the poor self-regenerative capability of cartilage. Hydrogel-based tissue engineering has been considered as an effective strategy. In this study, inspired...

scholarly journals Advanced Strategies for Articular Cartilage Defect Repair

Materials ◽  
2013 ◽  
Vol 6 (2) ◽  
pp. 637-668 ◽  
Author(s):  
Amos Matsiko ◽  
Tanya Levingstone ◽  
Fergal O'Brien
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Articular Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair

scholarly journals Chitosan composite scaffolds for articular cartilage defect repair: a review

RSC Advances ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 3736-3749 ◽  
Author(s):  
Huijun Li ◽  
Cheng Hu ◽  
Huijun Yu ◽  
Chuanzhong Chen
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Composite Scaffolds ◽  
Articular Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair ◽  
Chitosan Composite

Properties of chitosan/polymer and chitosan/bioceramic composite scaffolds for articular cartilage defect repair are reviewed.

Bilayer Collagen Membrane in Articular Cartilage Defect Repair

2017 ◽  
pp. 527-536
Author(s):  
Francesco Allegra ◽  
Enrico Bonacci ◽  
Gennaro Campopiano ◽  
Giovanni Corsini
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
Collagen Membrane ◽  
Articular Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair

scholarly journals Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1806
Author(s):  
Po-Chih Shen ◽  
Cheng-Chang Lu ◽  
Shih-Hsiang Chou ◽  
Zi-Miao Liu ◽  
Shu-Jem Su ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Cartilage Defect ◽  
Cell Sheet ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Cartilage Defects ◽  
Defect Model ◽  
Articular Cartilage Defect ◽  
Vitro Assay

The cell sheet technique is a promising approach for tissue engineering, and the present study is aimed to determine a better configuration of cell sheets for cartilage repair. For stratified chondrocyte sheets (S-CS), articular chondrocytes isolated from superficial, middle, and deep zones were stacked accordingly. Heterogeneous chondrocyte sheets (H-CS) were obtained by mixing zonal chondrocytes. The expressions of chondrocytes, cytokine markers, and glycosaminoglycan (GAG) production were assessed in an in vitro assay. The curative effect was investigated in an in vivo porcine osteochondral defect model. The S-CS showed a higher cell viability, proliferation rate, expression of chondrogenic markers, secretion of tissue inhibitor of metalloproteinase, and GAG production level than the H-CS group. The expressions of ECM destruction enzyme and proinflammatory cytokines were lower in the S-CS group. In the mini-pigs articular cartilage defect model, the S-CS group had a higher International Cartilage Repair Society (ICRS) macroscopic score and displayed a zonal structure that more closely resembled the native cartilage than those implanted with the H-CS. Our study demonstrated that the application of the S-CS increased the hyaline cartilage formation and improved the surgical outcome of chondrocyte implication, offering a better tissue engineering strategy for treating articular cartilage defects.

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