Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma

2021 ◽  
Author(s):  
Valentina Preziosi ◽  
Mario Barra ◽  
Giovanna Tomaiuolo ◽  
Pasquale D'Angelo ◽  
Simone Luigi Luigi Marasso ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Whole Blood ◽  
Electrical Response ◽  
Human Blood Plasma ◽  
Buffer Solutions ◽  
First Time ◽  
Organic Electrochemical Transistors

In this paper, for the first time to our knowledge, organic electrochemical transistors are employed to investigate the electrical response of human blood, plasma and alternative buffer solutions that inhibit...

scholarly journals An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Louise Ann Clark ◽  
Jochen Beyer ◽  
Andis Graudins
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Local Anaesthetic ◽  
Whole Blood ◽  
Lipid Emulsion ◽  
Equilibrium Dialysis ◽  
Human Blood Plasma ◽  
Intravenous Lipid Emulsion ◽  
Vitro Effect

Background. Intravenous lipid emulsion (ILE) is recommended as a “rescue” treatment for local anaesthetic (LA) toxicity. A purported mechanism of action suggests that lipophilic LAs are sequestered into an intravascular “lipid-sink,” thus reducing free drug concentration. There is limited data available correlating the effects of ILE on LAs.Aims. To compare the in vitro effect of ILE on LA concentrations in human blood/plasma and to correlate this reduction to LA lipophilicity.Method. One of four LAs (bupivacaine-most lipophilic-4 mg/L, ropivacaine-6 mg/L, lignocaine-14 mg/L, and prilocaine-least lipophilic-7 mg/L) was spiked into plasma or whole blood. ILE or control-buffer was added. Plasma was centrifuged to separate ILE and total-LA concentration assayed from the lipid-free fraction. Whole blood underwent equilibrium dialysis and free-LA concentration was measured. Percent reduction in LA concentration from control was compared between the LAs and correlated with lipophilicity.Results. ILE caused a significant reduction in total and free bupivacaine concentration compared with the other LAs. Ropivacaine had the least reduction in concentration, despite a lipophilicity similar to bupivacaine. The reduction in LA concentration correlated to increasing lipophilicity when ropivacaine was excluded from analysis.Conclusion. In this first in vitro model assessing both free- and total-LA concentrations exposed to ILE in human blood/plasma, ILE effect was linearly correlated with increasing lipophilicity for all but ropivacaine.

Change in human blood plasma pH with pressure

1981 ◽  
Vol 50 (2) ◽  
pp. 320-324 ◽  
Author(s):  
E. Morild
Keyword(s):  
Hydrostatic Pressure ◽  
Blood Plasma ◽  
Human Blood ◽  
Pressure Effect ◽  
Colorimetric Method ◽  
Human Blood Plasma ◽  
Liquid Equilibrium ◽  
First Time ◽  
Effect Of Hydrostatic Pressure

For the first time, the effect of hydrostatic pressure on the pH in human blood plasma was determined under well-defined conditions. By means of a colorimetric method the change in plasma pH was examined from 1 to 1,500 bar (atm). The change was -2.5 x 10(-4).bar-1, and it is then established that this effect is unimportant for physiologically tolerable pressures. A discussion of the gas-liquid equilibrium of CO2 is included, with a short consideration of the pressure effect on the hemoglobin system. x

How viscoelastic is human blood plasma?

Soft Matter ◽  
2018 ◽  
Vol 14 (21) ◽  
pp. 4238-4251 ◽  
Author(s):  
S. Varchanis ◽  
Y. Dimakopoulos ◽  
C. Wagner ◽  
J. Tsamopoulos
Keyword(s):  
Experimental Data ◽  
Constitutive Model ◽  
Blood Plasma ◽  
Human Blood ◽  
Viscoelastic Properties ◽  
Human Blood Plasma ◽  
Complex Flows ◽  
Rheological Response ◽  
First Time

In this work, we evaluate for first time the viscoelastic properties of human blood plasma. Using computational rheology, a molecular-based constitutive model and experimental data, we predict accurately the rheological response of human blood plasma in strong extensional and constriction complex flows.

Egg beater as centrifuge: isolating human blood plasma from whole blood in resource-poor settings

Lab on a Chip ◽  
2008 ◽  
Vol 8 (12) ◽  
pp. 2032 ◽  
Author(s):  
Amy P. Wong ◽  
Malancha Gupta ◽  
Sergey S. Shevkoplyas ◽  
George M. Whitesides
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Whole Blood ◽  
Human Blood Plasma ◽  
Resource Poor

Dual Layer Mixed Matrix Hollow Fiber Membranes for Outside-In Filtration of Human Blood Plasma

2020 ◽  
Author(s):  
O.E.M. ter Beek ◽  
M.K. van Gelder ◽  
C. Lokhorst ◽  
D.H.M. Hazenbrink ◽  
B.H. Lentferink ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Hollow Fiber ◽  
Human Blood Plasma ◽  
Hollow Fiber Membranes ◽  
Mixed Matrix ◽  
Fiber Membranes

scholarly journals Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma

2002 ◽  
Vol 43 (3) ◽  
pp. 365-374
Author(s):  
Elisa Campos ◽  
Leila Kotite ◽  
Patricia Blanche ◽  
Yasushi Mitsugi ◽  
Philip H. Frost ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Particle Fraction
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