A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury

2021 ◽  
Vol 9 (39) ◽  
pp. 8246-8252
Author(s):  
Xiangyang Gong ◽  
Dan Cheng ◽  
Wei Li ◽  
Yang Shen ◽  
Rong Peng ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
High Selectivity ◽  
Acute Liver Injury ◽  
Molecular Hybridization ◽  
Molecular Probe ◽  
Drug Induced ◽  
Ratiometric Fluorescent Probe ◽  
Complex Drug

Visualizing ONOO− fluctuations in the complex drug-induced acute liver injury process using a ratiometric fluorescent probe developed by using a molecular hybridization strategy with high selectivity and sensitivity.

A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

2019 ◽  
Vol 55 (95) ◽  
pp. 14307-14310 ◽  
Author(s):  
Wen-Li Jiang ◽  
Yongfei Li ◽  
Wen-Xin Wang ◽  
Yi-Ting Zhao ◽  
Junjie Fei ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Ratiometric Fluorescent Probe

A novel hepatocyte-targeting near-infrared ratiometric fluorescent probe named Gal-NIR is developed for detecting ONOO−. The probe can target the hepatocyte and assess drug-induced liver injury and its remediation in living cells and mice.

scholarly journals Fluorescent Probe for the Imaging of Superoxide and Peroxynitrite during Drug-induced Liver Injury

2021 ◽  
Author(s):  
Luling Wu ◽  
Jihong Liu ◽  
Xue Tian ◽  
Robin Rupert Groleau ◽  
Steven Bull ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Fluorescent Probe ◽  
Molecular Probe ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Fatal Liver

Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease. Herein, we report the development of a molecular probe (LW−OTf) for the detection and imaging of two...

A ratiometric fluorescence sensor for HOCl based on a FRET platform and application in living cells

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17059-17063 ◽  
Author(s):  
Yan-Ru Zhang ◽  
Zhi-Min Zhao ◽  
Le Su ◽  
Jun-Ying Miao ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Fast Response ◽  
Living Cells ◽  
Fluorescence Sensor ◽  
Ratiometric Fluorescence ◽  
Ratiometric Fluorescent Probe

A ratiometric fluorescent probe CRSH based on a FRET platform for detecting HOCl. CRSH showed high selectivity, excellent sensitivity and a fast response toward HOCl.

scholarly journals A highly selective ratiometric fluorescent probe for the cascade detection of Zn2+ and H2PO4− and its application in living cell imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (64) ◽  
pp. 40615-40620 ◽  
Author(s):  
Kui Du ◽  
Shizhen Niu ◽  
Li Qiao ◽  
Yandong Dou ◽  
Qing Zhu ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Fluorescent Probe ◽  
Living Cell ◽  
Cell Imaging ◽  
High Selectivity ◽  
Ratiometric Sensor ◽  
Intermolecular Charge Transfer ◽  
Living Cell Imaging ◽  
Ratiometric Fluorescent Probe

A simple ratiometric sensor (L1) for the cascade detection of Zn2+ and H2PO4− with high selectivity was reported based on the intermolecular charge transfer (ICT) mechanism.

A new ratiometric fluorescent probe for detecting endogenous HClO in living cells

2018 ◽  
Vol 42 (4) ◽  
pp. 2989-2993 ◽  
Author(s):  
Li-Jie Zhang ◽  
Jun-Ya Ning ◽  
Jun-Ying Miao ◽  
Jin-Ting Liu ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Living Cells ◽  
Ratiometric Fluorescent Probe

A new benzimidazole-hemicyanine-based ratiometric fluorescent probe (ZBM-H) was developed, which showed high selectivity and sensitivity for detecting HClO.

scholarly journals Acetaminophen Test Battery (ATB): A Comprehensive Method to Study Acetaminophen-Induced Acute Liver Injury

2020 ◽  
Vol 20 (2) ◽  
pp. 125-138 ◽  
Author(s):  
Bharat Bhushan ◽  
Udayan Apte
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Test Battery ◽  
Western World ◽  
Drug Induced ◽  
Technical Problems ◽  
Drug Induced Liver Injury ◽  
Comprehensive Method ◽  
Injury Models ◽  
Apap Hepatotoxicity

Acetaminophen (APAP) overdose is the major cause of acute liver failure (ALF) in the Western world. Extensive research is ongoing to identify the mechanisms of APAP-induced ALF. APAP-induced acute liver injury is also one of the most commonly studied drug-induced liver injury models in the field of hepatotoxicity. APAP toxicity is triphasic and includes three mechanistically interlinked but temporally distinct phases of initiation, progression, and recovery/regeneration. Despite how commonly it is studied, the methods to study APAP toxicity differ significantly, often leading to confusing and contradictory data. There are number of reviews on mechanisms of APAP toxicity, but a detailed mechanism-based comprehensive method and list of assays that covers all phases of APAP hepatotoxicity are missing. The goal of this review is to provide a standard protocol and guidelines to study APAP toxicity in mice including a test battery that can help investigators to comprehensively analyze APAP toxicity in the specific context of their hypothesis. Further, we will identify the major roadblocks and common technical problems that can significantly affect the results. This acetaminophen test battery (ATB) will be an excellent guide for scientists studying this most common and clinically relevant drug-induced liver injury and will also be helpful as a roadmap for hypothesis development to study novel mechanisms.

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