Carbon dots up-regulate heme oxygenase-1 expression towards the acute lung injury therapy

2021 ◽  
Author(s):  
Bo Wang ◽  
Peipei Liu ◽  
Hui Huang ◽  
Xiting Wang ◽  
Mengling Zhang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Carbon Dots ◽  
Morbidity And Mortality ◽  
Heme Oxygenase 1 ◽  
High Morbidity ◽  
A Cell

Pneumonia is a kind of inflammation, which can cause high morbidity and mortality, and the treatment of pneumonia has received widespread attention. Heme oxygenase-1 (HMOX 1) is a cell protective...

6-Gingerol Ameliorates Sepsis Induced Acute Lung Injury by Regulating Nuclear Factor-κB and Nuclear-Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Signaling Pathways

2020 ◽  
Vol 19 (3) ◽  
pp. 255-260
Author(s):  
Fan Yang ◽  
Lu Deng ◽  
MuHu Chen ◽  
Ying Liu ◽  
Jianpeng Zheng
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Alveolar Collapse ◽  
Factor Α

Acute lung injury initiated systemic inflammation leads to sepsis. Septic mice show a series of degenerative changes in lungs as demonstrated by pulmonary congestion, alveolar collapse, inflammatory cell infiltration, and increased wet-todry weight in lungs. 6-Gingerol ameliorates histopathological changes and clinical outcome of the sepsis. The increase in the levels of tumor necrosis factor-α, interleukin-1 beta, interleukin-6, and interleukin-18 in septic mice were reduced by administration with 6-Gingerol. Also, 6-Gingerol attenuates sepsis-induced increase of malonaldehyde and decrease of catalase, superoxide, and glutathione. Enhanced phospho-p65, reduced nuclear factor erythropoietin-2-related factor 2, and heme oxygenase 1 in septic mice were reversed by administration with 6-Gingerol. In conclusion, 6-Gingerol demonstrates anti-inflammatory and antioxidant effects against sepsis associated acute lung injury through inactivation of nuclear factor-kappa B and activation of nuclear-factor erythroid 2-related factor 2 pathways.

Heme oxygenase-1 ameliorates LPS-induced acute lung injury correlated with downregulation of interleukin-33

2011 ◽  
Vol 11 (12) ◽  
pp. 2112-2117 ◽  
Author(s):  
Hui Yin ◽  
Xiangyong Li ◽  
Baohong Yuan ◽  
Bobin Zhang ◽  
Shilian Hu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Interleukin 33

Acacetin attenuates mice endotoxin-induced acute lung injury via augmentation of heme oxygenase-1 activity

2017 ◽  
Vol 26 (2) ◽  
pp. 635-643 ◽  
Author(s):  
Dongdong Wu ◽  
Yanan Wang ◽  
Heng Zhang ◽  
Minghua Du ◽  
Tanshi Li
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

Protective Effects of Heme Oxygenase-1 in Acute Lung Injury

CHEST Journal ◽  
1999 ◽  
Vol 116 ◽  
pp. 61S-63S ◽  
Author(s):  
Leo E. Otterbein ◽  
Patty J. Lee ◽  
Beek Yoke Chin ◽  
Irina Petrache ◽  
Sharon L. Camhi ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Protective Effects
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