Photothermal slippery surfaces towards spatial droplets manipulation

Author(s):  
Keyu Han ◽  
Zubin Wang ◽  
Liping Heng ◽  
Lei Jiang

Intelligent responsive slippery surfaces with adjustable wettability present considerable significance in a broad range of fundamental research and application realms including microfluidic channels, microreactions, and liquid directional-conveying devices. Although considerable...

Author(s):  
J.A. Eades ◽  
E. Grünbaum

In the last decade and a half, thin film research, particularly research into problems associated with epitaxy, has developed from a simple empirical process of determining the conditions for epitaxy into a complex analytical and experimental study of the nucleation and growth process on the one hand and a technology of very great importance on the other. During this period the thin films group of the University of Chile has studied the epitaxy of metals on metal and insulating substrates. The development of the group, one of the first research groups in physics to be established in the country, has parallelled the increasing complexity of the field.The elaborate techniques and equipment now needed for research into thin films may be illustrated by considering the plant and facilities of this group as characteristic of a good system for the controlled deposition and study of thin films.


Author(s):  
E. V. Zolotuhina-Abolina

In the monograph of Professor A. M. Starostin the notions “philosophical novations” and “research philosophy” was introduced and approved. The author divides the whole array of philosophic research into fundamental and applied – the sphere of philosophical novations. Fundamental and philosophic investigations are directed to the study of the problems of objective reality, thinking, cognition, the truth, freedom and other basic categories. The sphere of fundamental research is slowly changing and it’s development is marked by the outstanding names (Platon, Descartes, Kant, Schopenhauer, Heidegger etc.). As to the sphere of the philosophic innovations, its emergence and development are connected with application of methods of philosophical reflection to the realization of interdisciplinary problems of science, development of political, religious, artistic, ethical trends, which can't be researched only with the help of their own methods. The sphere of philosophic novations develops dynamically and according to its own scales and is twice larger than the sphere of fundamental philosophy.In his monography the author, from the viewpoint of his treating of fundamental and innovative projection of the philosophic knowledge and philosophic methods, analyses contemporary problems of politics, education, culture, science.


Equipment ◽  
2006 ◽  
Author(s):  
C. Yang ◽  
G. Y. Tang ◽  
D. G. Yan ◽  
H. Q. Gong ◽  
John C. Chai ◽  
...  

2019 ◽  
Author(s):  
Lina Humbeck ◽  
Jette Pretzel ◽  
Saskia Spitzer ◽  
Oliver Koch

Knowledge about interrelationships between different proteins is crucial in fundamental research for the elucidation of protein networks and pathways. Furthermore, it is especially critical in chemical biology to identify further key regulators of a disease and to take advantage of polypharmacology effects. A comprehensive scaffold-based analysis uncovered an unexpected relationship between bromodomain-containing protein 4 (BRD4) and peroxisome-proliferator activated receptor gamma (PPARγ). They are both important drug targets for cancer therapy and many more important diseases. Both proteins share binding site similarities near a common hydrophobic subpocket which should allow the design of a polypharmacology-based ligand targeting both proteins. Such a dual-BRD4-PPARγ-modulator could show synergistic effects with a higher efficacy or delayed resistance development in, for example, cancer therapy. Thereon, a complex structure of sulfasalazine was obtained that involves two bromodomains and could be a potential starting point for the design of a bivalent BRD4 inhibitor.


2020 ◽  
Author(s):  
Xinkai Qiu ◽  
Sylvia Rousseva ◽  
Gang Ye ◽  
Jan C. Hummelen ◽  
Ryan Chiechi

This paper describes the reconfiguration of molecular tunneling junctions during operation via the self-assembly of bilayers of glycol ethers. We use well-established functional groups to modulate the magnitude and direction of rectification in assembled tunneling junctions by exposing them to solutions containing different glycol ethers. Variable-temperature measurements establish that rectification occurs by a bias-dependent tunneling-hopping mechanism and that glycol ethers, beside being an unusually efficient tunneling medium, behave identically to alkanes. We fabricated memory bits from crossbar junctions prepared by injecting eutectic Ga-In into microfluidic channels. Two 8-bit registers were able to perform logical AND operations on bit strings encoded into chemical packets as microfluidic droplets that alter the composition of the crossbar junctions through self-assembly to effect memristor-like properties. This proof of concept work demonstrates the potential for fieldable molecular-electronic devices based on tunneling junctions of self-assembled monolayers and bilayers.


2018 ◽  
Vol 26 (1) ◽  
pp. 101-109
Author(s):  
Yeon-Oh Han ◽  
Myung Kim ◽  
Tae-Seop Park ◽  
Jae-Hyun Lee

Author(s):  
Aleksandr Gorelov ◽  
Stanislav Gorelov ◽  
Nikolay Silkin

The results of analytical studies of the subject and subjectivity in relation to law enforcement officers based on the academicians Eddy V. Sayko and Anatoly A. Derkach’s fundamental research are presented in the article. Service in the internal Affairs bodies is a deterministic system. It is characterized by huge information flows, extreme neuropsychic and emotional loads, and complex interpersonal relationships. In this regard, increased requirements are imposed on employees of all levels of the law enforcement system. After studying the long-term dynamics of the level of readiness of cadets of educational organizations of the Ministry of internal Affairs of Russia in the framework of self-development, it can be concluded that specialized competencies formed in the classroom according to the traditional system are not transformedinto skills of the highest order. Based on the research, the obvious problem of further improving the methodology of teaching competent actions in the course of performing operational and service tasks in various conditions is revealed. It is reasonable that the traditional learning process involves the development of a specific algorithm of actions in standard situations of operational and service activities, and when introducing various tasks of modeling typical situations, students often cannot complete the task in changing conditions (beyond the standard).


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