Impact of cationic surfactant-induced DNA compaction on the characteristics of a minor groove bound flavonol

Soft Matter ◽  
2022 ◽  
Author(s):  
Dipanjan Halder ◽  
Pradipta Purkayastha
Keyword(s):  
Excited State ◽  
Cationic Surfactant ◽  
Minor Groove ◽  
Dna Compaction ◽  
Diagnostic Agent ◽  
A Minor

3-Hydroxyflavone (3-HF), which binds to the minor groove of DNA, is a strong antioxidant and hence a potent therapeutic and diagnostic agent. A special photo-property, called excited state intramolecular proton...

A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks via β-Elimination of 2-Deoxyribonolactone

2002 ◽  
Vol 124 (31) ◽  
pp. 9062-9063 ◽  
Author(s):  
Brian C. Bales ◽  
Marguerite Pitié ◽  
Bernard Meunier ◽  
Marc M. Greenberg
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Strand Breaks ◽  
A Minor

Specific DNA Recognition by a Synthetic, Monomeric Cys2His2 Zinc-Finger Peptide Conjugated to a Minor-Groove Binder

2007 ◽  
Vol 119 (36) ◽  
pp. 7010-7014 ◽  
Author(s):  
Olalla Vázquez ◽  
M. Eugenio Vázquez ◽  
Juan B. Blanco ◽  
Luis Castedo ◽  
José L. Mascareñas
Keyword(s):  
Zinc Finger ◽  
Dna Recognition ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
A Minor ◽  
Zinc Finger Peptide

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: Clarifying the role of N3-methyladenine

2014 ◽  
Vol 759 ◽  
pp. 45-51 ◽  
Author(s):  
Paola Monti ◽  
Giorgia Foggetti ◽  
Paola Menichini ◽  
Alberto Inga ◽  
Barry Gold ◽  
...  
Keyword(s):  
Biological Effects ◽  
Minor Groove ◽  
A Minor

scholarly journals Human DNA Polymerase ι Promotes Replication through a Ring-Closed Minor-Groove Adduct That Adopts a syn Conformation in DNA

2005 ◽  
Vol 25 (19) ◽  
pp. 8748-8754 ◽  
Author(s):  
William T. Wolfle ◽  
Robert E. Johnson ◽  
Irina G. Minko ◽  
R. Stephen Lloyd ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerases ◽  
Minor Groove ◽  
Dna Lesions ◽  
Unsaturated Aldehyde ◽  
Cyclic Form ◽  
Human Dna ◽  
A Minor ◽  
Dna Polymerase Ι

ABSTRACT Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. The reaction of acrolein with the N 2 group of guanine in DNA leads to the formation of a cyclic adduct, γ-hydroxy-1,N 2-propano-2′-deoxyguanosine (γ-HOPdG). Previously, we have shown that proficient replication through the γ-HOPdG adduct can be mediated by the sequential action of human DNA polymerases (Pols) ι and κ, in which Polι incorporates either pyrimidine opposite γ-HOPdG, but Polκ extends only from the cytosine. Since γ-HOPdG can adopt either a ring-closed cyclic form or a ring-opened form in DNA, to better understand the mechanisms that Pols ι and κ employ to promote replication through this lesion, we have examined the ability of these polymerases to replicate through the structural analogs of γ-HOPdG that are permanently either ring closed or ring opened. Our studies with these model adducts show that whereas the ring-opened form of γ-HOPdG is not inhibitory to synthesis by human Pols η, ι, or κ, only Polι is able to incorporate nucleotides opposite the ring-closed form, which is known to adopt a syn conformation in DNA. From these studies, we infer that (i) Pols η, ι, and κ have the ability to proficiently replicate through minor-groove DNA lesions that do not perturb the Watson-Crick hydrogen bonding of the template base with the incoming nucleotide, and (ii) Polι can accommodate a minor-groove-adducted template purine which adopts a syn conformation in DNA and forms a Hoogsteen base pair with the incoming nucleotide.

scholarly journals Detection of the Bacillus anthracis gyrA Gene by Using a Minor Groove Binder Probe

2004 ◽  
Vol 42 (1) ◽  
pp. 179-185 ◽  
Author(s):  
W. Hurtle ◽  
E. Bode ◽  
D. A. Kulesh ◽  
R. S. Kaplan ◽  
J. Garrison ◽  
...  
Keyword(s):  
Bacillus Anthracis ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Gyra Gene ◽  
Minor Groove Binder Probe ◽  
A Minor

scholarly journals Sensitive Assay for Quantification of Hepatitis B Virus Mutants by Use of a Minor Groove Binder Probe and Peptide Nucleic Acids

2010 ◽  
Vol 48 (12) ◽  
pp. 4487-4494 ◽  
Author(s):  
Shuhei Hige ◽  
Yoichi Yamamoto ◽  
Shigeru Yoshida ◽  
Tomoe Kobayashi ◽  
Hiromasa Horimoto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Minor Groove ◽  
Sensitive Assay ◽  
Minor Groove Binder ◽  
B Virus ◽  
Minor Groove Binder Probe ◽  
A Minor
Sign in / Sign up

Export Citation Format

Share Document