Tuning cell adhesion on supported lipid bilayers via nanoscale geometry

Soft Matter ◽  
2021 ◽  
Author(s):  
Long Li ◽  
Jie Gao ◽  
Yingfeng Shao ◽  
Fan Song ◽  
Jinglei Hu
Keyword(s):  
Cell Adhesion ◽  
Lipid Bilayers ◽  
Model Systems ◽  
Supported Lipid Bilayers ◽  
Membrane Interface ◽  
Receptor Ligand ◽  
Ligand Interactions

The adhesion of cells to supported lipid bilayers (SLBs) has been widely used as model systems to study the receptor-ligand interactions that cause the membrane interface. The ligand-functionalized SLBs are...

scholarly journals Recruitment of receptors at supported lipid bilayers promoted by the multivalent binding of ligand-modified unilamellar vesicles

2020 ◽  
Vol 11 (12) ◽  
pp. 3307-3315 ◽  
Author(s):  
Daniele Di Iorio ◽  
Yao Lu ◽  
Joris Meulman ◽  
Jurriaan Huskens
Keyword(s):  
Lipid Bilayers ◽  
Model Systems ◽  
Supported Lipid Bilayers ◽  
Biological Interactions ◽  
Unilamellar Vesicles ◽  
Multivalent Binding

The development of model systems that mimic biological interactions and allow the control of both receptor and ligand densities, is essential for a molecular understanding of biomolecular processes, such as the recruitment of receptors at interfaces.

scholarly journals E-Cadherin Tethered to Micropatterned Supported Lipid Bilayers as a Model for Cell Adhesion

Langmuir ◽  
2005 ◽  
Vol 21 (25) ◽  
pp. 11963-11968 ◽  
Author(s):  
Tomas D. Perez ◽  
W. James Nelson ◽  
Steven G. Boxer ◽  
Lance Kam
Keyword(s):  
Cell Adhesion ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers ◽  
E Cadherin

scholarly journals Peptide-presenting two-dimensional protein matrix on supported lipid bilayers: An efficient platform for cell adhesion

2007 ◽  
Vol 2 (4) ◽  
pp. 165-172 ◽  
Author(s):  
Rémi Bérat ◽  
Murielle Rémy-Zolghadry ◽  
Céline Gounou ◽  
Claude Manigand ◽  
Sisareuth Tan ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers ◽  
Two Dimensional ◽  
Protein Matrix

scholarly journals Urea-mediated anomalous diffusion in supported lipid bilayers

2018 ◽  
Vol 8 (5) ◽  
pp. 20180028 ◽  
Author(s):  
E. E. Weatherill ◽  
H. L. E. Coker ◽  
M. R. Cheetham ◽  
M. I. Wallace
Keyword(s):  
Brownian Motion ◽  
Polyethylene Glycol ◽  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Anomalous Diffusion ◽  
Incubation Time ◽  
Time Scale ◽  
Biological Membranes ◽  
Model Systems ◽  
Supported Lipid Bilayers

Diffusion in biological membranes is seldom simply Brownian motion; instead, the rate of diffusion is dependent on the time scale of observation and so is often described as anomalous. In order to help better understand this phenomenon, model systems are needed where the anomalous diffusion of the lipid bilayer can be tuned and quantified. We recently demonstrated one such model by controlling the excluded area fraction in supported lipid bilayers (SLBs) through the incorporation of lipids derivatized with polyethylene glycol. Here, we extend this work, using urea to induce anomalous diffusion in SLBs. By tuning incubation time and urea concentration, we produce bilayers that exhibit anomalous behaviour on the same scale as that observed in biological membranes.

Patterning Adjacent Supported Lipid Bilayers of Desired Composition To Investigate Receptor−Ligand Binding under Shear Flow

Langmuir ◽  
2004 ◽  
Vol 20 (23) ◽  
pp. 10252-10259 ◽  
Author(s):  
Kelley A. Burridge ◽  
Michael A. Figa ◽  
Joyce Y. Wong
Keyword(s):  
Shear Flow ◽  
Ligand Binding ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers ◽  
Receptor Ligand

Cell adhesion on supported lipid bilayers

2003 ◽  
Vol 64A (4) ◽  
pp. 622-629 ◽  
Author(s):  
Ann-Sofie Andersson ◽  
Karin Glasmästar ◽  
Duncan Sutherland ◽  
Ulf Lidberg ◽  
Bengt Kasemo
Keyword(s):  
Cell Adhesion ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers
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