A simple strategy for efficient preparation of networks based on poly(2-isopropenyl-2-oxazoline), poly(ethylene oxide), and selected biologically active compounds: Novel hydrogels with antibacterial properties

Soft Matter ◽  
2021 ◽  
Author(s):  
Bartosz Kopka ◽  
Bartłomiej Kost ◽  
Katarzyna Rajkowska ◽  
Andrzej Pawlak ◽  
Alina Kunicka-Styczyńska ◽  
...  

Novel polymer networks composed of biocompatible, hydrophilic poly(2-isopropenyl-2-oxazoline), poly(ethylene oxide), and biologically active compounds (cinnamic acid, benzoic acid or eugenol) were developed for potential antimicrobial applications.

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1263 ◽  
Author(s):  
Jaroslav Kousal ◽  
Jana Sedlaříková ◽  
Zuzana Kolářová-Rašková ◽  
Zdeněk Krtouš ◽  
Liliana Kučerová ◽  
...  

Poly(ethylene oxide) (PEO)-like thin films were successfully prepared by plasma-assisted vapor thermal deposition (PAVTD). PEO powders with a molar weight (Mw) between 1500 g/mol and 600,000 g/mol were used as bulk precursors. The effect of Mw on the structural and surface properties was analyzed for PEO films prepared at a lower plasma power. Fourier transform (FTIR-ATR) spectroscopy showed that the molecular structure was well preserved regardless of the Mw of the precursors. The stronger impact of the process conditions (the presence/absence of plasma) was proved. Molecular weight polydispersity, as well as wettability, increased in the samples prepared at 5 W. The influence of deposition plasma power (0–30 W) on solubility and permeation properties was evaluated for a bulk precursor of Mw 1500 g/mol. The rate of thickness loss after immersion in water was found to be tunable in this way, with the films prepared at the highest plasma power showing higher stability. The effect of plasma power deposition conditions was also shown during the permeability study. Prepared PEO films were used as a cover, and permeation layers for biologically active nisin molecule and a controlled release of this bacteriocin into water was achieved.


2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Jia Li ◽  
Bo-Xiang Wang ◽  
Yi-Fan Cui ◽  
Zhi-Cai Yu ◽  
Xu Hao ◽  
...  

Nanosilver particle has been used in the nanofiber mats by mixing the nanosilver with the spinning solution for improving the antibacterial property. Although studies have shown that the antibacterial property of nanofiber mats gets increasing, the higher silver content and the larger released resistance of nanosilver from nanofiber mats are obvious. Here, the electrospinning-combined postdeposition method was used to prepare the nanosilver/sericin/poly(ethylene oxide) (Ag/SS/PEO) nanofiber mats and the bacterial reduction rates againstStaphylococcus aureus(S. aureus) andEscherichia coli(E. coli) were analyzed. We found that the Ag/SS/PEO nanofiber mats were excellent antibacterial properties at the lower silver content and the bacterial reduction rates againstS. aureusandE. coliall reached above 99.99%. Our data suggests that the antibacterial property can be improved by introducing the electrospinning-combined postdeposition method.


2010 ◽  
Vol 29 (2) ◽  
pp. 169 ◽  
Author(s):  
Ružica Jovanović-Malinovska ◽  
Maja Cvetkovska ◽  
Slobodanka Kuzmanova ◽  
Christo Tsvetanov ◽  
Eleonora Winkelhausen

Hydrogel matrices were designed as hybrid networks of poly(ethylene oxide) (PEO) with natural polymers,alginate or chitosan by UV irradiation. The networks were formulated in the single-stage procedure inwhich the alginate or chitosan were added to the crosslinking reaction solution of PEO, and two-stage procedure,with additional chemical crosslinking of alginate or chitosan. Double-layer hydrogels composed of PEOhydrogel core with entrapped cells and outer natural hydrogel layer were also synthesized. The hydrogels werecharacterized by gel fraction yield and degree of equilibrium swelling as well as by rheological measurements.The production of ethanol by immobilized Saccharomyces cerevisiae was used to test the suitability of the synthesizedhybrid hydrogels to serve as carriers for cell immobilization. The presence of cells affected the mechanicalproperties and the structure of the polymer networks. The best system for immobilization was found to bethe PEO/alginate/Ca, which exhibited high mechanical strength (G′, 830; GF, 93; ESH2O, 15) without affectingthe metabolic functions of the cells. The maximum ethanol yield was 0.42 g/g corresponding to 82 % of thetheoretical yield.


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