scholarly journals Interaction between SARS-CoV-2 spike glycoprotein and human skin models: a molecular dynamics study

Soft Matter ◽  
2021 ◽  
Author(s):  
Marc Domingo ◽  
Jordi Faraudo
Keyword(s):  
Molecular Dynamics ◽  
Human Skin ◽  
Respiratory Viruses ◽  
Spike Glycoprotein ◽  
Indirect Transmission ◽  
Physico Chemical ◽  
Human Skin Models

The possibility of contamination of human skin by infectious virions plays an important role in indirect transmission of respiratory viruses but little is known about the fundamental physico-chemical aspects of...

scholarly journals Interaction between SARS-CoV-2 spike glycoprotein and human skin models: a molecular dynamics study

2021 ◽  
Author(s):  
Marc Domingo ◽  
Jordi Faraudo
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Skin Surface ◽  
Viral Envelope ◽  
Solid Surfaces ◽  
Spike Glycoprotein ◽  
Indirect Transmission ◽  
Physico Chemical ◽  
Human Skin Models ◽  
Structure Orientation

The possibility of contamination of human skin by infectious virions plays an important role in indirect transmission of respiratory viruses but little is known about the fundamental physico-chemical aspects of the virus-skin interactions. In the case of coronaviruses, the interaction with surfaces (including the skin surface) is mediated by their large glycoprotein spikes that protrude from (and cover) the viral envelope. Here, we perform all atomic simulations between the SARS-CoV-2 spike glycoprotein and human skin models. We consider an "oily" skin covered by sebum and a "clean" skin exposing the stratum corneum. The simulations show that the spike tries to maximize the contacts with stratum corneum lipids, particularly ceramides, with substantial hydrogen bonding. In the case of "oily" skin, the spike is able to retain its structure, orientation and hydration over sebum with little interaction with sebum components. Comparison of these results with our previous simulations of the interaction of SARS-CoV-2 spike with hydrophilic and hydrophobic solid surfaces, suggests that the"soft" or "hard" nature of the surface plays an essential role in the interaction of the spike protein with materials.

scholarly journals Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities

View ◽  
2021 ◽  
pp. 20210012
Author(s):  
Emily Sutterby ◽  
Peter Thurgood ◽  
Sara Baratchi ◽  
Khashayar Khoshmanesh ◽  
Elena Pirogova
Keyword(s):  
Human Skin ◽  
Treatment Modalities ◽  
Human Skin Models

scholarly journals Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174478 ◽  
Author(s):  
Arnout Mieremet ◽  
Marion Rietveld ◽  
Samira Absalah ◽  
Jeroen van Smeden ◽  
Joke A. Bouwstra ◽  
...  
Keyword(s):  
Human Skin ◽  
Epidermal Barrier ◽  
Barrier Formation ◽  
Dermal Matrices ◽  
Human Skin Models

Application of MatTekIn VitroReconstructed Human Skin Models for Safety, Efficacy Screening, and Basic Preclinical Research

2015 ◽  
Vol 1 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Patrick J. Hayden ◽  
Michael Bachelor ◽  
Seyoum Ayehunie ◽  
Silvia Letasiova ◽  
Yulia Kaluzhny ◽  
...  
Keyword(s):  
Human Skin ◽  
Preclinical Research ◽  
Human Skin Models

Comparison of Cutaneous Bioavailability of Cosmetic Preparations Containing Caffeine or α-Tocopherol Applied on Human Skin Models or Human Skin ex vivo at Finite Doses

2002 ◽  
Vol 15 (1) ◽  
pp. 40-58 ◽  
Author(s):  
Frank Dreher ◽  
Frédéric Fouchard ◽  
Claire Patouillet ◽  
Michèle Andrian ◽  
Jean-Thierry Simonnet ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Human Skin Models
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