pH-Dependent Complexation and Polyelectrolyte Chain Conformation of Polyzwitterion-Polycation Coacervates in Salted Water

Soft Matter ◽  
2021 ◽  
Author(s):  
Kehua Lin ◽  
Benxin Jing ◽  
Yingxi Zhu
Keyword(s):  
Aqueous Solution ◽  
Phase Behavior ◽  
Cationic Polyelectrolyte ◽  
Chain Conformation ◽  
Conformational Structure ◽  
Charge Fraction ◽  
Polyelectrolyte Chain ◽  
Ph Dependent

The phase behavior and chain conformational structure of biphasic polyzwitterion-polyelectrolyte coacervates in salted aqueous solution are investigated with a model weak cationic polyelectrolyte, poly(2-vinylpyridine) (P2VP), whose charge fraction can be...

Influence of Charge Fraction on the Phase Behavior of Symmetric Single-Ion Conducting Diblock Copolymers

2021 ◽  
pp. 1035-1040
Author(s):  
Bo Zhang ◽  
Caini Zheng ◽  
Michael B. Sims ◽  
Frank S. Bates ◽  
Timothy P. Lodge
Keyword(s):  
Phase Behavior ◽  
Diblock Copolymers ◽  
Charge Fraction ◽  
Ion Conducting

pH-Dependent Phase Behavior and Stability of Cationic Lipid–mRNA Nanoparticles

2021 ◽  
Author(s):  
Nicholas R. Larson ◽  
Gang Hu ◽  
Yangjie Wei ◽  
Anthony Tuesesca ◽  
M. Laird Forrest ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Cationic Lipid ◽  
Ph Dependent

Effects of Alcohols and Counterions on the Phase Behavior of 1-Octyl-3-methylimidazolium Chloride Aqueous Solution

2007 ◽  
Vol 111 (40) ◽  
pp. 11708-11713 ◽  
Author(s):  
Guodong Zhang ◽  
Xiao Chen ◽  
Yurong Zhao ◽  
Yizhou Xie ◽  
Huayu Qiu
Keyword(s):  
Aqueous Solution ◽  
Phase Behavior

scholarly journals Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Yu ◽  
Chaoqun Xu ◽  
Chuanwei Lu ◽  
Qian Liu ◽  
Jifu Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Vegetable Oils ◽  
Renewable Resources ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Dehydroabietic Acid ◽  
Great Promise ◽  
Loading Capacity ◽  
Carboxylic Groups ◽  
Ph Dependent

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

scholarly journals Flexibility of Short-Strand RNA in Aqueous Solution as Revealed by Molecular Dynamics Simulation: Are A-RNA and A´-RNA Distinct Conformational Structures?

2009 ◽  
Vol 62 (9) ◽  
pp. 1054 ◽  
Author(s):  
Defang Ouyang ◽  
Hong Zhang ◽  
Dirk-Peter Herten ◽  
Harendra S. Parekh ◽  
Sean C. Smith
Keyword(s):  
Molecular Dynamics ◽  
Aqueous Solution ◽  
Structural Information ◽  
Structural Parameters ◽  
Biological Molecules ◽  
Dynamics Simulation ◽  
Viral Gene ◽  
Conformational Structure ◽  
Crystal Forms ◽  
Gene Delivery Vectors

We use molecular dynamics simulations to compare the conformational structure and dynamics of a 21-base pair RNA sequence initially constructed according to the canonical A-RNA and A′-RNA forms in the presence of counterions and explicit water. Our study aims to add a dynamical perspective to the solid-state structural information that has been derived from X-ray data for these two characteristic forms of RNA. Analysis of the three main structural descriptors commonly used to differentiate between the two forms of RNA – namely major groove width, inclination and the number of base pairs in a helical twist – over a 30 ns simulation period reveals a flexible structure in aqueous solution with fluctuations in the values of these structural parameters encompassing the range between the two crystal forms and more. This provides evidence to suggest that the identification of distinct A-RNA and A′-RNA structures, while relevant in the crystalline form, may not be generally relevant in the context of RNA in the aqueous phase. The apparent structural flexibility observed in our simulations is likely to bear ramifications for the interactions of RNA with biological molecules (e.g. proteins) and non-biological molecules (e.g. non-viral gene delivery vectors).

Photochemical retro-aldol type reactions of nitrobenzyl derivatives. Mechanistic variations in the elimination of nitrobenzyl carbanions from nitrobenzyl derivatives on photolysis

1986 ◽  
Vol 64 (9) ◽  
pp. 1949-1951 ◽  
Author(s):  
Peter Wan ◽  
S. Muralidharan
Keyword(s):  
Aqueous Solution ◽  
Leaving Group ◽  
Ph Dependent

The photochemical retro-aldol type reactions of several nitrobenzyl derivatives are reported. The reactions are observed only in aqueous solution with quantum efficiencies being pH dependent for several derivatives, consistent with the existence of several mechanistic pathways for reaction. The primary photochemical event is believed to involve the generation of a nitrobenzyl carbanion, which acts as a photolabile leaving group in these reactions, and the generation of an oxocarbocation (or oxocarbocation-derived) fragment.

Thermoresponsive behavior of poly(N-isopropylacrylamide)s with dodecyl and carboxyl terminal groups in aqueous solution: pH-dependent cloud point temperature

2017 ◽  
Vol 295 (8) ◽  
pp. 1343-1349 ◽  
Author(s):  
Juraj Škvarla ◽  
Rahul K. Raya ◽  
Mariusz Uchman ◽  
Jiří Zedník ◽  
Karel Procházka ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Cloud Point ◽  
Solution Ph ◽  
Point Temperature ◽  
Cloud Point Temperature ◽  
Ph Dependent ◽  
Carboxyl Terminal
Sign in / Sign up

Export Citation Format

Share Document