Hemorheology: the critical role of flow type on blood viscosity measurements

Soft Matter ◽  
2021 ◽  
Author(s):  
Elahe Javadi ◽  
Safa Jamali
Keyword(s):  
Drug Delivery ◽  
Blood Viscosity ◽  
Crucial Role ◽  
Critical Role ◽  
Blood Rheology ◽  
Viscosity Measurements ◽  
Flow Type

The crucial role of hemorheological characteristics of blood in a range of diagnoses, treatments and drug delivery mechanisms is widely accepted. Nonetheless, the literature on blood rheology remains inconclusive and...

scholarly journals Correction: Hemorheology: the critical role of flow type in blood viscosity measurements

Soft Matter ◽  
2021 ◽  
Author(s):  
Elahe Javadi ◽  
Safa Jamali
Keyword(s):  
Blood Viscosity ◽  
Soft Matter ◽  
Critical Role ◽  
Viscosity Measurements ◽  
Flow Type

Correction for ‘Hemorheology: the critical role of flow type in blood viscosity measurements’ by Elahe Javadi et al., Soft Matter, 2021, 17, 8446–8458, DOI: 10.1039/D1SM00856K.

Critical role of water stability in metal–organic frameworks and advanced modification strategies for the extension of their applicability

2020 ◽  
Vol 7 (5) ◽  
pp. 1319-1347 ◽  
Author(s):  
Botao Liu ◽  
Kumar Vikrant ◽  
Ki-Hyun Kim ◽  
Vanish Kumar ◽  
Suresh Kumar Kailasa
Keyword(s):  
Drug Delivery ◽  
Water Purification ◽  
Gas Adsorption ◽  
Critical Role ◽  
Metal Organic Frameworks ◽  
Water Stability ◽  
Metal Organic

Metal–organic frameworks (MOFs) are well known for their versatile applications in diverse fields (e.g., gas adsorption, water purification, sensing, drug delivery, and catalysis).

scholarly journals Critical role of spectrin in hearing development and deafness

2019 ◽  
Vol 5 (4) ◽  
pp. eaav7803 ◽  
Author(s):  
Yan Liu ◽  
Jieyu Qi ◽  
Xin Chen ◽  
Mingliang Tang ◽  
Cenfeng Chu ◽  
...  
Keyword(s):  
Hair Cells ◽  
Knockout Mice ◽  
Crucial Role ◽  
Structural Organization ◽  
Critical Role ◽  
Super Resolution ◽  
Mechanical Vibrations ◽  
Hearing Ability ◽  
Profound Deafness

Inner ear hair cells (HCs) detect sound through the deflection of mechanosensory stereocilia. Stereocilia are inserted into the cuticular plate of HCs by parallel actin rootlets, where they convert sound-induced mechanical vibrations into electrical signals. The molecules that support these rootlets and enable them to withstand constant mechanical stresses underpin our ability to hear. However, the structures of these molecules have remained unknown. We hypothesized that αII- and βII-spectrin subunits fulfill this role, and investigated their structural organization in rodent HCs. Using super-resolution fluorescence imaging, we found that spectrin formed ring-like structures around the base of stereocilia rootlets. These spectrin rings were associated with the hearing ability of mice. Further, HC-specific, βII-spectrin knockout mice displayed profound deafness. Overall, our work has identified and characterized structures of spectrin that play a crucial role in mammalian hearing development.

scholarly journals Modeling Adipogenesis: Current and Future Perspective

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2326 ◽  
Author(s):  
Hisham F. Bahmad ◽  
Reem Daouk ◽  
Joseph Azar ◽  
Jiranuwat Sapudom ◽  
Jeremy C. M. Teo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Crucial Role ◽  
Critical Role ◽  
Treatment Modalities ◽  
Future Perspective ◽  
Adipose Derived Stem Cells ◽  
Physiological Importance ◽  
And Personalized Medicine

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells’ differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.

scholarly journals Immune Cells in Cancer Therapy and Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Ceren Eyileten ◽  
Kinga Majchrzak ◽  
Zofia Pilch ◽  
Katarzyna Tonecka ◽  
Joanna Mucha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
T Cells ◽  
Dendritic Cells ◽  
Immune Cells ◽  
Critical Role ◽  
Tumour Microenvironment ◽  
Cytokines And Chemokines

Recent studies indicate the critical role of tumour associated macrophages, tumour associated neutrophils, dendritic cells, T lymphocytes, and natural killer cells in tumourigenesis. These cells can have a significant impact on the tumour microenvironment via their production of cytokines and chemokines. Additionally, products secreted from all these cells have defined specific roles in regulating tumour cell proliferation, angiogenesis, and metastasis. They act in a protumour capacityin vivoas evidenced by the recent studies indicating that macrophages, T cells, and neutrophils may be manipulated to exhibit cytotoxic activity against tumours. Therefore therapy targeting these cells may be promising, or they may constitute drug or anticancer particles delivery systems to the tumours. Herein, we discussed all these possibilities that may be used in cancer treatment.

Low-dose paclitaxel via hyaluronan-functionalized bovine serum albumin nanoparticulate assembly for metastatic melanoma treatment

2020 ◽  
Vol 8 (10) ◽  
pp. 2139-2147
Author(s):  
Xue Chen ◽  
Mou Wang ◽  
Ying Hu ◽  
Tao Gong ◽  
Zhi-Rong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Targeted Drug Delivery ◽  
Low Dose ◽  
Critical Role ◽  
Cell Adhesion And Migration ◽  
Melanoma Treatment ◽  
Targeted Drug ◽  
And Migration

Due to the critical role of CD44 in mediating cell adhesion and migration, CD44-targeted drug delivery via hyaluronan has been extensively explored.

scholarly journals Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 685
Author(s):  
Zerrin Sezgin-Bayindir ◽  
Sonia Losada-Barreiro ◽  
Carlos Bravo-Díaz ◽  
Matej Sova ◽  
Julijana Kristl ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Critical Role ◽  
Delivery Systems ◽  
Related Factor ◽  
New Horizons ◽  
Therapeutic Benefits ◽  
Anticancer Treatment

The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery of new therapeutic agents and potential drug delivery systems. In particular, the introduction of nano-sized drug delivery systems (NDDSs) has opened new horizons for effective cancer treatment. These are considered potential systems that provide deep tissue penetration and specific drug targeting. On the other hand, nuclear factor erythroid 2-related factor 2 (NRF2)-based anticancer treatment approaches have attracted tremendous attention and produced encouraging results. However, the lack of effective formulation strategies is one of the factors that hinder the clinical application of NRF2 modulators. In this review, we initially focus on the critical role of NRF2 in cancer cells and NRF2-based anticancer treatment. Subsequently, we review the preparation and characterization of NDDSs encapsulating NRF2 modulators and discuss their potential for cancer therapy.

A comparative study of blood rheology across species

Soft Matter ◽  
2021 ◽  
Author(s):  
Jeffrey S. Horner ◽  
Norman J. Wagner ◽  
Antony N. Beris
Keyword(s):  
Comparative Study ◽  
Power Law ◽  
Blood Viscosity ◽  
Allometric Scaling ◽  
Blood Rheology ◽  
Data Sources ◽  
Viscosity Measurements ◽  
Power Law Exponent ◽  
Low Shear

When normalized by hematocrit, low-shear blood viscosity measurements across species exhibit allometric scaling with a power law exponent close to 1/4. See paper for an explanation on the data sources.

Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy

Blood ◽  
2007 ◽  
Vol 110 (1) ◽  
pp. 424-432 ◽  
Author(s):  
Natalija Buza-Vidas ◽  
Min Cheng ◽  
Sara Duarte ◽  
Hojjatollah Nozad ◽  
Sten Eirik W. Jacobsen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
B Cells ◽  
B Cell ◽  
Crucial Role ◽  
Marrow Transplantation ◽  
Immune Reconstitution ◽  
Critical Role ◽  
B Lymphopoiesis

Almost 5 decades after the first clinical transplantations, delayed immune reconstitution remains a considerable hurdle in bone marrow transplantation, and the mechanisms regulating immune reconstitution after transplantation remain to be established. Whereas adult fms-like tyrosine kinase 3 ligand–deficient (FL−/−) mice have reduced numbers of early B- and T-cell progenitors, they sustain close to normal levels of mature B and T cells. Herein, we demonstrate that adult bone marrow cells fail to reconstitute B-cell progenitors and conventional B cells in lethally irradiated FL−/− recipients, which also display delayed kinetics of T-cell reconstitution. Similarly, FL is essential for B-cell regeneration after chemotherapy-induced myeloablation. In contrast, fetal progenitors reconstitute B lymphopoiesis in FL−/− mice, albeit at reduced levels. A critical role of FL in adult B lymphopoiesis is further substantiated by an age-progressive decline in peripheral conventional B cells in FL−/− mice, whereas fetally and early postnatally derived B1 and marginal zone B cells are sustained in a FL-independent manner. Thus, FL plays a crucial role in sustaining conventional B lymphopoiesis in adult mice and, as a consequence, our findings implicate a critical role of FL in promoting immune reconstitution after myeloablation and bone marrow transplantation.

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