A simulation study of controlling chirality and number of strands for helices self-assembled from achiral block copolymers under confinement of a nanopore

Soft Matter ◽  
2021 ◽  
Author(s):  
Xiejun Hu ◽  
Zheng Wang ◽  
Yuhua Yin ◽  
Run Jiang ◽  
Baohui Li
Keyword(s):  
Block Copolymers ◽  
Simulation Study ◽  
Helical Structures ◽  
Self Assembled

Achiral block copolymers can self-assemble into helical structures when confined within a cylindrical nanopore. Controlling the chirality and number of strands of helices, however, is challenging. We present our simulation...

Hierarchically Ordered Microstructures Self-Assembled from Comb−Coil Block Copolymers

Langmuir ◽  
2009 ◽  
Vol 25 (8) ◽  
pp. 4735-4742 ◽  
Author(s):  
Liquan Wang ◽  
Jiaping Lin ◽  
Liangshun Zhang
Keyword(s):  
Block Copolymers ◽  
Self Assembled ◽  
Ordered Microstructures

scholarly journals Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics

2020 ◽  
Vol 11 ◽  
Author(s):  
Jazmin Torres ◽  
Namdev Dhas ◽  
Marcela Longhi ◽  
Mónica C. García
Keyword(s):  
Block Copolymers ◽  
Cancer Treatment ◽  
Common Life ◽  
Biological Barriers ◽  
Life Threatening Illness ◽  
Ability To Act ◽  
Anticancer Therapeutics ◽  
Life Threatening ◽  
Self Assembled ◽  
Treatment And Diagnosis

Cancer is one of the most common life-threatening illness and it is the world’s second largest cause of death. Chemotherapeutic anticancer drugs have many disadvantages, which led to the need to develop novel strategies to overcome these shortcomings. Moreover, tumors are heterogenous in nature and there are various biological barriers that assist in treatment reisistance. In this sense, nanotechnology has provided new strategies for delivery of anticancer therapeutics. Recently, delivery platforms for overcoming biological barriers raised by tumor cells and tumor-bearing hosts have been reported. Among them, amphiphilic block copolymers (ABC)-based self-assembled nanocarriers have attracted researchers worldwide owing to their unique properties. In this work, we addressed different biological barriers for effective cancer treatment along with several strategies to overcome them by using ABC‐based self-assembled nanostructures, with special emphasis in those that have the ability to act as responsive nanocarriers to internal or external environmental clues to trigger release of the payload. These nanocarriers have shown promising properties to revolutionize cancer treatment and diagnosis, but there are still challenges for their successful translation to clinical applications.

Orthogonally Self-Assembled Multifunctional Block Copolymers

2009 ◽  
Vol 15 (44) ◽  
pp. 11904-11911 ◽  
Author(s):  
Ashootosh V. Ambade ◽  
Caroline Burd ◽  
Mary Nell Higley ◽  
Kamlesh P. Nair ◽  
Marcus Weck
Keyword(s):  
Block Copolymers ◽  
Self Assembled

A stepwise crosslinking strategy toward lamellar carbon frameworks with covalently connected alternate layers of porous carbon nanosheets and porous carbon spacers

2018 ◽  
Vol 54 (73) ◽  
pp. 10332-10335 ◽  
Author(s):  
Junlong Huang ◽  
Yanhuan Lin ◽  
Shaohong Liu ◽  
Qiantong Liu ◽  
Yiwei Sun ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Porous Carbon ◽  
Carbon Nanosheets ◽  
Self Assembled

Lamellar carbon frameworks with covalently connected alternate layers of porous carbon nanosheets and porous carbon spacers were successfully fabricated based on the stepwise crosslinking of self-assembled lamellar block copolymers.

Superhelices with tunable twisting power directed from supramolecular pairing of focal asymmetry in achiral dendron-jacketed block copolymers

2020 ◽  
Vol 8 (6) ◽  
pp. 1923-1932 ◽  
Author(s):  
I-Ming Lin ◽  
Che-Min Chou ◽  
Ming-Chia Li ◽  
Rong-Hao Guo ◽  
Cheng-Kuang Lee ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Quaternary Structure ◽  
Molecular Level ◽  
Helical Structures

Focal asymmetry was introduced into achiral dendron-jacketed block copolymers for the formation of hierarchical helical structures via transfer of helical twisting from a primary molecular level to a quaternary structure.

scholarly journals Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2572
Author(s):  
Jaleesa Bresseleers ◽  
Mahsa Bagheri ◽  
Coralie Lebleu ◽  
Sébastien Lecommandoux ◽  
Olivier Sandre ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Size Difference ◽  
Flow Rates ◽  
Polymer Vesicles ◽  
Attractive Option ◽  
Self Assembled ◽  
Size And Morphology ◽  
Poly Ethylene ◽  
Careful Design

The careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.

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