Efficient One-Pot Tandem Catalysis of Glucose into 1,1,2-Trimethoxyethane over W-Beta Catalyst

2022 ◽  
Author(s):  
Xinpeng Zhao ◽  
Wang Liu ◽  
Lijun Zhu ◽  
Yanfei Zhang ◽  
Mengya Sun ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
Tandem Catalysis ◽  
One Pot ◽  
Efficient Transformation ◽  
Tungsten Species

One-pot efficient transformation of glucose to 1,1,2-trimethoxyethane via epimerization, retro-aldol condensation (RAC), acetalization, and etherification processes over W-Beta catalyst in methanol phase was proposed. Uniform dispersive 0.5 wt% tungsten species...

scholarly journals One-Pot Access to 2-Aryl-3-(arylmethyl)chromones

Synthesis ◽  
2019 ◽  
Vol 52 (06) ◽  
pp. 861-872
Author(s):  
Meng-Yang Chang ◽  
Kuan-Ting Chen ◽  
Yu-Lin Tsai ◽  
Han-Yu Chen
Keyword(s):  
Sodium Hydroxide ◽  
Aldol Condensation ◽  
One Pot ◽  
Mild Conditions ◽  
Efficient Transformation ◽  
Plausible Mechanism

Sodium hydroxide controlled intermolecular double aldol condensation of o-hydroxyacetophenones with 2 equivalents of aryl­aldehydes provides 2-aryl-3-(arylmethyl)chromones (a chimera of flavone and homoisoflavanone) in MeOH at 50 °C under mild conditions. The uses of various bases and solvents are investigated for one-pot facile and efficient transformation. A plausible mechanism is proposed.

Both sites must turn over in tandem catalysis: Lessons from one-pot CO2 capture and hydrogenation

2021 ◽  
Author(s):  
Elizabeth A. K. Wilson ◽  
Shawn C. Eady ◽  
Trent Silbaugh ◽  
Levi T. Thompson ◽  
Mark A. Barteau
Keyword(s):  
Co2 Capture ◽  
Tandem Catalysis ◽  
One Pot ◽  
Turn Over

scholarly journals Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

2021 ◽  
Vol 16 (4) ◽  
pp. 1934578X2110100
Author(s):  
Pham The Chinh ◽  
Pham Thi Tham ◽  
Duong Huong Quynh ◽  
Nguyen Van Tuyen ◽  
Dinh Thuy Van ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Aldol Condensation ◽  
One Pot ◽  
Aryl Group ◽  
Vascular Disrupting Agents ◽  
Benzaldehyde Derivatives ◽  
Vascular Disrupting

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), and ( Z)−3-(( Z)−4-chlorobenzylidene)−1,4-dimethyl-6-((8-methyl-4-nitroquinolin-2-yl)methylene)piperazine-2,5-dione (8) showed strong cytotoxicity against 3 of the cancer cells lines (KB, HepG2 and Lu) with IC50 values ranging from 3.04 to 10.62 µM. The quinoline-derived compounds had higher cytotoxic activity than the benzaldehyde derivatives. The successful synthesis of these derivatives offers useful information for the development of more potent vascular disrupting agents based on plinabulin.

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

One-pot tandem catalysis over Pd@MIL-101: boosting the efficiency of nitro compound hydrogenation by coupling with ammonia borane dehydrogenation

2015 ◽  
Vol 51 (52) ◽  
pp. 10419-10422 ◽  
Author(s):  
Qihao Yang ◽  
Yu-Zhen Chen ◽  
Zhiyong U. Wang ◽  
Qiang Xu ◽  
Hai-Long Jiang
Keyword(s):  
Nitro Compound ◽  
Ammonia Borane ◽  
Nitro Compounds ◽  
Tandem Catalysis ◽  
One Pot

The hydrogenation efficiency of nitro compounds is greatly boosted by coupling with ammonia borane dehydrogenation over rationally synthesized Pd@MIL-101 with Pd NPs in ∼3 nm.

Petal-shaped MOF assembled with gold nanocage and urate oxidase used as artificial enzyme nanohybrid for tandem catalysis and dual-channel biosensing

Nanoscale ◽  
2021 ◽  
Author(s):  
Zejun Sun ◽  
Yujiao Sun ◽  
Meng Yang ◽  
Hui Jin ◽  
Rijun Gui
Keyword(s):  
Metal Organic Frameworks ◽  
Urate Oxidase ◽  
Tandem Catalysis ◽  
Artificial Enzyme ◽  
One Pot ◽  
Mild Conditions ◽  
Dual Channel ◽  
Metal Organic

A facile one-pot precipitation was employed to prepare a petal-shaped hybrid in mild conditions. The hybrid is composed of urate oxidase (UOx) encapsulated into zeolite-like metal-organic frameworks (MOF) with doping...

A new aldol condensation of .alpha.-allenic esters with aldehydes, including a one-pot synthesis of enyne compounds

1993 ◽  
Vol 58 (22) ◽  
pp. 5952-5957 ◽  
Author(s):  
Sadao Tsuboi ◽  
Hirofumi Kuroda ◽  
Satoshi Takatsuka ◽  
Takashi Fukawa ◽  
Takashi Sakai ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Allenic Esters

Deep Oxidative Desulfurization of Dibenzothiophene by Functional Tungsten-Containing Mesoporoussilica from Polyoxometalate-Based Salts

2014 ◽  
Vol 636 ◽  
pp. 93-96
Author(s):  
Ming Zhang ◽  
Wen Shuai Zhu ◽  
Meng Li ◽  
Yan An Li ◽  
Suhang Xun ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Organic Solvents ◽  
Room Temperature ◽  
Oxidative Desulfurization ◽  
Catalytic Performance ◽  
Sulfur Compounds ◽  
High Dispersion ◽  
One Pot ◽  
Tungsten Species

Tungsten-containing functional mesoporousW-SiO2 have been successfully synthesized by an one-pot and facile room-temperature procedure. These materials presented a high dispersion of tungsten species and excellent catalytic activity on the removal of sulfur compounds without any organic solvents as extractants. The catalytic performance on sulfur compounds was investigated in detail. After recycling for 8 times, the removal of the oxidation desulfurization system could still reach 92.0%.

scholarly journals Chalcones and Flavanones Bearing Hydroxyl and/or Methoxyl Groups: Synthesis and Biological Assessments

2019 ◽  
Vol 9 (14) ◽  
pp. 2846 ◽  
Author(s):  
Gonçalo P. Rosa ◽  
Ana M. L. Seca ◽  
Maria do Carmo Barreto ◽  
Artur M. S. Silva ◽  
Diana C. G. A. Pinto
Keyword(s):  
Aldol Condensation ◽  
Biological Activities ◽  
Sodium Hydride ◽  
Antitumor Activities ◽  
One Pot ◽  
Substitution Pattern ◽  
Control Drug ◽  
Wide Range ◽  
Biological Assessments ◽  
Isomeric Structures

Chalcones and flavanones are isomeric structures and also classes of natural products, belonging to the flavonoid family. Moreover, their wide range of biological activities makes them key scaffolds for the synthesis of new and more efficient drugs. In this work, the synthesis of hydroxy and/or methoxychalcones was studied using less common bases, such as sodium hydride (NaH) and lithium bis(trimethylsilyl)amide (LiHMDS), in the aldol condensation. The results show that the use of NaH was more effective for the synthesis of 2′-hydroxychalcone derivatives, while LiHMDS led to the synthesis of polyhydroxylated chalcones in a one-pot process. During this study, it was also possible to establish the conditions that favor their isomerization into flavanones, allowing at the same time the synthesis of hydroxy and/or methoxyflavanones. The chalcones and flavanones obtained were evaluated to disclose their antioxidant, anticholinesterasic, antibacterial and antitumor activities. 2′,4′,4-Trihydroxychalcone was the most active compound in terms of antioxidant, anti-butyrylcholinesterase (IC50 26.55 ± 0.55 μg/mL, similar to control drug donepezil, IC50 28.94 ± 1.76 μg/mL) and antimicrobial activity. 4′,7-Dihydroxyflavanone presented dual inhibition, that is, the ability to inhibit both cholinesterases. 4′-Hydroxy-5,7-dimethoxyflavanone and 2′-hydroxy-4-methoxychalcone were the compounds with the best antitumor activity. The substitution pattern and the biological assay results allowed the establishment of some structure/activity relationships.

Sign in / Sign up

Export Citation Format

Share Document