scholarly journals Bioinspired nonheme iron complex that triggers mitochondrial apoptotic signalling pathway specifically for colorectal cancer cells

2022 ◽  
Author(s):  
Yool Lee ◽  
Chaeun Oh ◽  
Jin Kim ◽  
Myong-Suk Park ◽  
Woo Kyun Bae ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Metal Ion ◽  
Iron Complex ◽  
Nonheme Iron ◽  
Signalling Pathway ◽  
Biological Functions ◽  
Reductive Activation ◽  
Colorectal Cancer Cells

The activation of dioxygen is the keystone of all forms of aerobic life. Many biological functions rely on the redox versatility of metal ion to perform reductive activation-mediated processes entailing...

CXCR4 promotes adhesion capacity and activates the AKT signalling pathway in colorectal cancer cells

2017 ◽  
Vol 72 ◽  
pp. S68
Author(s):  
F. Zheng ◽  
V. Flamini ◽  
R. Bradbury ◽  
Z. Zhang ◽  
W.G. Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signalling Pathway ◽  
Colorectal Cancer Cells

scholarly journals Genomic determinants of protein abundance variation in colorectal cancer cells

2016 ◽  
Author(s):  
Theodoros I. Roumeliotis ◽  
Steven Paul Williams ◽  
Emanuel Gonçalves ◽  
Fatemeh Zamanzad Ghavidel ◽  
Nanne Aben ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Protein Interactions ◽  
Metal Ion ◽  
Genomic Variation ◽  
List Type ◽  
Integrative View ◽  
Colorectal Cancer Cells ◽  
Chromatin Modifiers

SummaryAssessing the extent to which genomic alterations compromise the integrity of the proteome is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling and tribrid mass spectrometry to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the relationships between genomic and proteomic variation. The robust quantification of 12,000 proteins and 27,000 phosphopeptides revealed how protein symbiosis translates to a co-variome which is subjected to a hierarchical order and exposes the collateral effects of somatic mutations on protein complexes. Targeted depletion of key chromatin modifiers confirmed the transmission of variation and the directionality as characteristics of protein interactions. Protein level variation was leveraged to build drug response predictive models towards a better understanding of pharmacoproteomic interactions in colorectal cancer. Overall, we provide a deep integrative view of the molecular structure underlying the variation of colorectal cancer cells.HighlightsThe cancer cell functional “co-variome” is a strong attribute of the proteome.Mutations can have a direct impact on protein levels of chromatin modifiers.Transmission of genomic variation is a characteristic of protein interactions.Pharmacoproteomic models are strong predictors of response to DNA damaging agents.AbbreviationsCOREADColorectal AdenocarcinomaIMACImmobilized Metal ion Affinity ChromatographyROCReceiver Operating CharacteristicAUCArea Under the CurveWGCNAWeighted Correlation Network AnalysisCNACopy Number AlterationSOMSelf-Organizing MapQTLQuantitative Trait LociMSIMicrosatellite InstabilityCPSColorectal Proteomic Subtypes

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