scholarly journals Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

2021 ◽  
Author(s):  
Dorothea Fiedler ◽  
Volker Haucke ◽  
Berke Türkaydin ◽  
David Furkert ◽  
Gillian Leigh Dornan ◽  
...  
Keyword(s):  
Molecular Level ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Cellular Processes ◽  
Inositol Pyrophosphates

Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are densely phosphorylated eukaryotic messengers, which are involved in numerous cellular processes. To elucidate their signaling functions at the molecular level, non-hydrolyzable bisphosphonate...

Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis

2018 ◽  
Vol 15 (7) ◽  
pp. 610-617 ◽  
Author(s):  
Huifeng Zhang ◽  
Dan Liu ◽  
Huanhuan Huang ◽  
Yujia Zhao ◽  
Hui Zhou
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Enzyme Activity ◽  
Protein Level ◽  
Senile Plaque ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Significant Difference

Background: β-amyloid (Aβ) accumulates abnormally to senile plaque which is the initiator of Alzheimer's disease (AD). As one of the Aβ-degrading enzymes, Insulin-degrading enzyme (IDE) remains controversial for its protein level and activity in Alzheimer's brain. Methods: The electronic databases PubMed, EMBASE, The Cochrane Library, OVID and Sinomed were systemically searched up to Sep. 20th, 2017. And the published case-control or cohort studies were retrieved to perform the meta-analysis. Results: Seven studies for IDE protein level (AD cases = 293; controls = 126), three for mRNA level (AD cases = 138; controls = 81), and three for enzyme activity (AD cases = 123; controls = 75) were pooling together. The IDE protein level was significantly lower in AD cases than in controls (SMD = - 0.47, 95% CI [-0.69, -0.24], p < 0.001), but IDE mRNA and enzyme activity had no significant difference (SMD = 0.02, 95% CI [-0.40, 0.43] and SMD = 0.06, 95% CI [-0.41, 0.53] respectively). Subgroup analyses found that IDE protein level was decreased in both cortex and hippocampus of AD cases (SMD = -0.43, 95% CI [-0.71, -0.16], p = 0.002 and SMD = -0.53, 95% CI [-0.91, -0.15], p = 0.006 respectively). However, IDE mRNA was higher in cortex of AD cases (SMD = 0.71, 95% CI [0.14, 1.29], p = 0.01), not in hippocampus (SMD = -0.26, 95% CI [-0.58, 0.06]). Conclusions: Our results indicate that AD patients may have lower IDE protease level. Further relevant studies are still needed to verify whether IDE is one of the factors affecting Aβ abnormal accumulation and throw new insights for AD detection or therapy.

scholarly journals Isolation of an Insulin-degrading Enzyme from Beef Liver

1959 ◽  
Vol 234 (2) ◽  
pp. 307-310 ◽  
Author(s):  
Henry H. Tomizawa ◽  
Yadviga Dowmont Halsey
Keyword(s):  
Insulin Degrading Enzyme ◽  
Beef Liver ◽  
Degrading Enzyme

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

2015 ◽  
Vol 51 (86) ◽  
pp. 15724-15727 ◽  
Author(s):  
G. Grasso ◽  
V. Lanza ◽  
G. Malgieri ◽  
R. Fattorusso ◽  
A. Pietropaolo ◽  
...  
Keyword(s):  
Insulin Degrading Enzyme ◽  
Degrading Enzyme

Insulin degrading enzyme: a metalloprotease with ubiquitin activating ability.

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